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Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

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Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. / Calabrese, Vittorio; Cornelius, Carolin; Dinkova-Kostova, Albena T.; Iavicoli, Ivo; Di Paola, Rosanna; Koverech, Aleardo; Cuzzocrea, Salvatore; Rizzarelli, Enrico; Calabrese, Edward J.

In: Biochimica et Biophysica Acta. Molecular Basis of Disease, Vol. 1822, No. 5, 05.2012, p. 753-783.

Research output: Contribution to journalScientific review

Harvard

Calabrese, V, Cornelius, C, Dinkova-Kostova, AT, Iavicoli, I, Di Paola, R, Koverech, A, Cuzzocrea, S, Rizzarelli, E & Calabrese, EJ 2012, 'Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity' Biochimica et Biophysica Acta. Molecular Basis of Disease, vol 1822, no. 5, pp. 753-783.

APA

Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E., & Calabrese, E. J. (2012). Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1822(5), 753-783doi: 10.1016/j.bbadis.2011.11.002

Vancouver

Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A et al. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochimica et Biophysica Acta. Molecular Basis of Disease. 2012 May;1822(5):753-783.

Author

Calabrese, Vittorio; Cornelius, Carolin; Dinkova-Kostova, Albena T.; Iavicoli, Ivo; Di Paola, Rosanna; Koverech, Aleardo; Cuzzocrea, Salvatore; Rizzarelli, Enrico; Calabrese, Edward J. / Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity.

In: Biochimica et Biophysica Acta. Molecular Basis of Disease, Vol. 1822, No. 5, 05.2012, p. 753-783.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{73dab0b4e206425d8ff364ab723122e1,
title = "Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity",
author = "Vittorio Calabrese and Carolin Cornelius and Dinkova-Kostova, {Albena T.} and Ivo Iavicoli and {Di Paola}, Rosanna and Aleardo Koverech and Salvatore Cuzzocrea and Enrico Rizzarelli and Calabrese, {Edward J.}",
year = "2012",
volume = "1822",
number = "5",
pages = "753--783",
journal = "Biochimica et Biophysica Acta. Molecular Basis of Disease",
issn = "0925-4439",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

A1 - Calabrese,Vittorio

A1 - Cornelius,Carolin

A1 - Dinkova-Kostova,Albena T.

A1 - Iavicoli,Ivo

A1 - Di Paola,Rosanna

A1 - Koverech,Aleardo

A1 - Cuzzocrea,Salvatore

A1 - Rizzarelli,Enrico

A1 - Calabrese,Edward J.

AU - Calabrese,Vittorio

AU - Cornelius,Carolin

AU - Dinkova-Kostova,Albena T.

AU - Iavicoli,Ivo

AU - Di Paola,Rosanna

AU - Koverech,Aleardo

AU - Cuzzocrea,Salvatore

AU - Rizzarelli,Enrico

AU - Calabrese,Edward J.

PY - 2012/5

Y1 - 2012/5

N2 - <p>Modulation of endogenous cellular defense mechanisms represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. This paper introduces the emerging role of exogenous molecules in hormetic-based neuroprotection and the mitochondrial redox signaling concept of hormesis and its applications to the field of neuroprotection and longevity. Maintenance of optimal long-term health conditions is accomplished by a complex network of longevity assurance processes that are controlled by vitagenes, a group of genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Hsp70, the thioredoxin and the sirtuin protein systems. Dietary antioxidants, such as polyphenols and L-carnitine/acetyl-L-carnitine, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways: including vitagenes. Hormesis provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their dose response relationships, their mechanistic foundations, their relationship to the concept of biological plasticity as well as providing a key insight for improving the accuracy of the therapeutic dose of pharmaceutical agents within the highly heterogeneous human population. This paper describes in mechanistic detail how hormetic dose responses are mediated for endogenous cellular defense pathways including sirtuin, Nrfs and related pathways that integrate adaptive stress responses in the prevention of neurodegenerative diseases. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease. (C) 2011 Elsevier B.V. All rights reserved.</p>

AB - <p>Modulation of endogenous cellular defense mechanisms represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. This paper introduces the emerging role of exogenous molecules in hormetic-based neuroprotection and the mitochondrial redox signaling concept of hormesis and its applications to the field of neuroprotection and longevity. Maintenance of optimal long-term health conditions is accomplished by a complex network of longevity assurance processes that are controlled by vitagenes, a group of genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Hsp70, the thioredoxin and the sirtuin protein systems. Dietary antioxidants, such as polyphenols and L-carnitine/acetyl-L-carnitine, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways: including vitagenes. Hormesis provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their dose response relationships, their mechanistic foundations, their relationship to the concept of biological plasticity as well as providing a key insight for improving the accuracy of the therapeutic dose of pharmaceutical agents within the highly heterogeneous human population. This paper describes in mechanistic detail how hormetic dose responses are mediated for endogenous cellular defense pathways including sirtuin, Nrfs and related pathways that integrate adaptive stress responses in the prevention of neurodegenerative diseases. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease. (C) 2011 Elsevier B.V. All rights reserved.</p>

U2 - 10.1016/j.bbadis.2011.11.002

DO - 10.1016/j.bbadis.2011.11.002

M1 - Scientific review

JO - Biochimica et Biophysica Acta. Molecular Basis of Disease

JF - Biochimica et Biophysica Acta. Molecular Basis of Disease

SN - 0925-4439

IS - 5

VL - 1822

SP - 753

EP - 783

ER -

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