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Characterization of TAE684 as a potent LRRK2 kinase inhibitor

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

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Original languageEnglish
Pages1864-1869
Number of pages6
JournalBioorganic & Medicinal Chemistry Letters
Journal publication date1 Mar 2012
Volume22
Issue5
Early online date28/01/12
DOIs
StatePublished

Abstract

Leucine-rich repeat kinase 2 (LRRK2) is linked to Parkinson's disease and may represent an attractive therapeutic target. Here we report a 2,4-dianilino-5-chloro-pyrimidine, TAE684, a previously reported inhibitor of anaplastic lymphoma kinase (ALK), is also a potent inhibitor of LRRK2 kinase activity (IC50 of 7.8 nM against wild-type LRRK2, 6.1 nM against the G2019S mutant). TAE684 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 mu M in cells and in mouse spleen and kidney, but not in brain, following oral doses of 10 mg/kg. (c) 2012 Elsevier Ltd. All rights reserved.

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