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Chromatin as an oxygen sensor and active player in the hypoxia response

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Chromatin as an oxygen sensor and active player in the hypoxia response. / Melvin, Andrew; Rocha, Sonia.

In: Cellular Signalling, Vol. 24, No. 1, 01.2012, p. 35-43.

Research output: Contribution to journalScientific review

Harvard

Melvin, A & Rocha, S 2012, 'Chromatin as an oxygen sensor and active player in the hypoxia response' Cellular Signalling, vol 24, no. 1, pp. 35-43., 10.1016/j.cellsig.2011.08.019

APA

Melvin, A., & Rocha, S. (2012). Chromatin as an oxygen sensor and active player in the hypoxia response. Cellular Signalling, 24(1), 35-43. 10.1016/j.cellsig.2011.08.019

Vancouver

Melvin A, Rocha S. Chromatin as an oxygen sensor and active player in the hypoxia response. Cellular Signalling. 2012 Jan;24(1):35-43. Available from: 10.1016/j.cellsig.2011.08.019

Author

Melvin, Andrew; Rocha, Sonia / Chromatin as an oxygen sensor and active player in the hypoxia response.

In: Cellular Signalling, Vol. 24, No. 1, 01.2012, p. 35-43.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{5095b0542a11471399b60ec2ed2152ab,
title = "Chromatin as an oxygen sensor and active player in the hypoxia response",
keywords = "Hypoxia, Chromatin, HIF, Transcription, Chromatin remodellers, JmjC demethylases, INDUCIBLE FACTOR 1-ALPHA, HYDROXYLASE DOMAIN PROTEIN-2, HISTONE DEMETHYLASE JMJD2B, GENE-EXPRESSION, DNA METHYLATION, BREAST-CANCER, EPIGENETIC REGULATION, VASCULAR DEVELOPMENT, FACTOR (HIF)-1-ALPHA, LYSINE DEMETHYLASE",
author = "Andrew Melvin and Sonia Rocha",
year = "2012",
doi = "10.1016/j.cellsig.2011.08.019",
volume = "24",
number = "1",
pages = "35--43",
journal = "Cellular Signalling",
issn = "0898-6568",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Chromatin as an oxygen sensor and active player in the hypoxia response

A1 - Melvin,Andrew

A1 - Rocha,Sonia

AU - Melvin,Andrew

AU - Rocha,Sonia

PY - 2012/1

Y1 - 2012/1

N2 - <p>Changes in the availability or demand for oxygen induce dramatic changes at the cellular level. Primarily, activation of a family of oxygen labile transcription factors, Hypoxia Inducible Factor (HIF), initiates a variety of cellular processes required to re-instate oxygen homeostasis. Oxygen is sensed by molecular dioxygenases in cells, such as the prolyl-hydroxylases (PHDs), enzymes which are responsible for the oxygen-dependent regulation of HIF. As HIF is a transcription factor it must bind DNA sequences of its target genes possibly in the context of a complex chromatin structure. How chromatin structure changes in response to hypoxia is currently unknown. However, the identification of a novel class of histone demethylases as true dioxygenases suggests that chromatin can act as an oxygen sensor and plays an active role in the coordination of the cellular response to hypoxia. This review will discuss the current knowledge on how hypoxia engages with different proteins involved in chromatin organisation and dynamics. (C) 2011 Elsevier Inc. All rights reserved.</p>

AB - <p>Changes in the availability or demand for oxygen induce dramatic changes at the cellular level. Primarily, activation of a family of oxygen labile transcription factors, Hypoxia Inducible Factor (HIF), initiates a variety of cellular processes required to re-instate oxygen homeostasis. Oxygen is sensed by molecular dioxygenases in cells, such as the prolyl-hydroxylases (PHDs), enzymes which are responsible for the oxygen-dependent regulation of HIF. As HIF is a transcription factor it must bind DNA sequences of its target genes possibly in the context of a complex chromatin structure. How chromatin structure changes in response to hypoxia is currently unknown. However, the identification of a novel class of histone demethylases as true dioxygenases suggests that chromatin can act as an oxygen sensor and plays an active role in the coordination of the cellular response to hypoxia. This review will discuss the current knowledge on how hypoxia engages with different proteins involved in chromatin organisation and dynamics. (C) 2011 Elsevier Inc. All rights reserved.</p>

KW - Hypoxia

KW - Chromatin

KW - HIF

KW - Transcription

KW - Chromatin remodellers

KW - JmjC demethylases

KW - INDUCIBLE FACTOR 1-ALPHA

KW - HYDROXYLASE DOMAIN PROTEIN-2

KW - HISTONE DEMETHYLASE JMJD2B

KW - GENE-EXPRESSION

KW - DNA METHYLATION

KW - BREAST-CANCER

KW - EPIGENETIC REGULATION

KW - VASCULAR DEVELOPMENT

KW - FACTOR (HIF)-1-ALPHA

KW - LYSINE DEMETHYLASE

U2 - 10.1016/j.cellsig.2011.08.019

DO - 10.1016/j.cellsig.2011.08.019

M1 - Scientific review

JO - Cellular Signalling

JF - Cellular Signalling

SN - 0898-6568

IS - 1

VL - 24

SP - 35

EP - 43

ER -

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