Discovery - University of Dundee - Online Publications

Library & Learning Centre

Clinical and economic burden of Clostridium difficile infection in Europe

Standard

Clinical and economic burden of Clostridium difficile infection in Europe : a systematic review of healthcare-facility-acquired infection. / Wiegand, P. N.; Nathwani, D.; Wilcox, M. H.; Stephens, J.; Shelbaya, A.; Haider, S.

In: Journal of Hospital Infection, Vol. 81, No. 1, 05.2012, p. 1-14.

Research output: Contribution to journalScientific review

Harvard

Wiegand, PN, Nathwani, D, Wilcox, MH, Stephens, J, Shelbaya, A & Haider, S 2012, 'Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection' Journal of Hospital Infection, vol 81, no. 1, pp. 1-14.

APA

Wiegand, P. N., Nathwani, D., Wilcox, M. H., Stephens, J., Shelbaya, A., & Haider, S. (2012). Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection. Journal of Hospital Infection, 81(1), 1-14doi: 10.1016/j.jhin.2012.02.004

Vancouver

Wiegand PN, Nathwani D, Wilcox MH, Stephens J, Shelbaya A, Haider S. Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection. Journal of Hospital Infection. 2012 May;81(1):1-14.

Author

Wiegand, P. N.; Nathwani, D.; Wilcox, M. H.; Stephens, J.; Shelbaya, A.; Haider, S. / Clinical and economic burden of Clostridium difficile infection in Europe : a systematic review of healthcare-facility-acquired infection.

In: Journal of Hospital Infection, Vol. 81, No. 1, 05.2012, p. 1-14.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{11a6ab12f781435da98b81d341c5db67,
title = "Clinical and economic burden of Clostridium difficile infection in Europe",
author = "Wiegand, {P. N.} and D. Nathwani and Wilcox, {M. H.} and J. Stephens and A. Shelbaya and S. Haider",
year = "2012",
volume = "81",
number = "1",
pages = "1--14",
journal = "Journal of Hospital Infection",
issn = "0195-6701",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Clinical and economic burden of Clostridium difficile infection in Europe

T2 - a systematic review of healthcare-facility-acquired infection

A1 - Wiegand,P. N.

A1 - Nathwani,D.

A1 - Wilcox,M. H.

A1 - Stephens,J.

A1 - Shelbaya,A.

A1 - Haider,S.

AU - Wiegand,P. N.

AU - Nathwani,D.

AU - Wilcox,M. H.

AU - Stephens,J.

AU - Shelbaya,A.

AU - Haider,S.

PY - 2012/5

Y1 - 2012/5

N2 - <p>PubMed, EMBASE and conference abstracts were reviewed systematically to determine the clinical and economic burden associated with Clostridium difficile infection (CDI) acquired and treated in European healthcare facilities. Inclusion criteria were: published in the English language between 2000 and 2010, and study population of at least 20 patients with documented CDI acquired/treated in European healthcare facilities. Data collection was completed by three unblinded reviewers using the Cochrane Handbook and PRISMA statement. The primary outcomes were mortality, recurrence, length of hospital stay (LOS) and cost related to CDI. In total, 1138 primary articles and conference abstracts were identified, and this was narrowed to 39 and 30 studies, respectively. Data were available from 14 countries, with 47% of studies from UK institutions. CDI mortality at 30 days ranged from 2% (France) to 42% (UK). Mortality rates more than doubled from 1999 to 2004, and continued to rise until 2007 when reductions were noted in the UK. Recurrent CDI varied from 1% (France) to 36% (Ireland); however, recurrence definitions varied between studies. Median LOS ranged from eight days (Belgium) to 27 days (UK). The incremental cost of CDI was 4577 pound in Ireland and 8843 pound in Germany, after standardization to 2010 prices. Country-specific estimates, weighted by sample size, ranged from 2.8% to 29.8% for 30-day mortality and from 16 to 37 days for LOS. CDI burden in Europe was most commonly described using 30-day mortality, recurrence, LOS and cost data. The continued spread of CDI and resultant healthcare burden underscores the need for judicious use of antibiotics. (C) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.</p>

AB - <p>PubMed, EMBASE and conference abstracts were reviewed systematically to determine the clinical and economic burden associated with Clostridium difficile infection (CDI) acquired and treated in European healthcare facilities. Inclusion criteria were: published in the English language between 2000 and 2010, and study population of at least 20 patients with documented CDI acquired/treated in European healthcare facilities. Data collection was completed by three unblinded reviewers using the Cochrane Handbook and PRISMA statement. The primary outcomes were mortality, recurrence, length of hospital stay (LOS) and cost related to CDI. In total, 1138 primary articles and conference abstracts were identified, and this was narrowed to 39 and 30 studies, respectively. Data were available from 14 countries, with 47% of studies from UK institutions. CDI mortality at 30 days ranged from 2% (France) to 42% (UK). Mortality rates more than doubled from 1999 to 2004, and continued to rise until 2007 when reductions were noted in the UK. Recurrent CDI varied from 1% (France) to 36% (Ireland); however, recurrence definitions varied between studies. Median LOS ranged from eight days (Belgium) to 27 days (UK). The incremental cost of CDI was 4577 pound in Ireland and 8843 pound in Germany, after standardization to 2010 prices. Country-specific estimates, weighted by sample size, ranged from 2.8% to 29.8% for 30-day mortality and from 16 to 37 days for LOS. CDI burden in Europe was most commonly described using 30-day mortality, recurrence, LOS and cost data. The continued spread of CDI and resultant healthcare burden underscores the need for judicious use of antibiotics. (C) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.</p>

U2 - 10.1016/j.jhin.2012.02.004

DO - 10.1016/j.jhin.2012.02.004

M1 - Scientific review

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

SN - 0195-6701

IS - 1

VL - 81

SP - 1

EP - 14

ER -

Documents

Library & Learning Centre

Contact | Accessibility | Policy