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Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study

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Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study. / Palmer, Colin N. A.; Kimber, Charlotte H.; Doney, Alex, S. F.; Proia, Anna S.; Morris, Andrew D.; Gaetani, Eleonora; Quarta, Miriam; Smith, Roy C.; Pola, Roberto.

In: Diabetes, Vol. 59, No. 11, 11.2010, p. 2945-2948.

Research output: Contribution to journalArticle

Harvard

Palmer, CNA, Kimber, CH, Doney, ASF, Proia, AS, Morris, AD, Gaetani, E, Quarta, M, Smith, RC & Pola, R 2010, 'Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study' Diabetes, vol 59, no. 11, pp. 2945-2948.

APA

Palmer, C. N. A., Kimber, C. H., Doney, A. S. F., Proia, A. S., Morris, A. D., Gaetani, E., Quarta, M., Smith, R. C., & Pola, R. (2010). Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study. Diabetes, 59(11), 2945-2948doi: 10.2337/db09-1690

Vancouver

Palmer CNA, Kimber CH, Doney ASF, Proia AS, Morris AD, Gaetani E et al. Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study. Diabetes. 2010 Nov;59(11):2945-2948.

Author

Palmer, Colin N. A.; Kimber, Charlotte H.; Doney, Alex, S. F.; Proia, Anna S.; Morris, Andrew D.; Gaetani, Eleonora; Quarta, Miriam; Smith, Roy C.; Pola, Roberto / Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study.

In: Diabetes, Vol. 59, No. 11, 11.2010, p. 2945-2948.

Research output: Contribution to journalArticle

Bibtex - Download

@article{3f49e025ee8a465892d82c40f664b869,
title = "Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study",
author = "Palmer, {Colin N. A.} and Kimber, {Charlotte H.} and Doney, {Alex, S. F.} and Proia, {Anna S.} and Morris, {Andrew D.} and Eleonora Gaetani and Miriam Quarta and Smith, {Roy C.} and Roberto Pola",
year = "2010",
volume = "59",
number = "11",
pages = "2945--2948",
journal = "Diabetes",
issn = "0012-1797",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study

A1 - Palmer,Colin N. A.

A1 - Kimber,Charlotte H.

A1 - Doney,Alex, S. F.

A1 - Proia,Anna S.

A1 - Morris,Andrew D.

A1 - Gaetani,Eleonora

A1 - Quarta,Miriam

A1 - Smith,Roy C.

A1 - Pola,Roberto

AU - Palmer,Colin N. A.

AU - Kimber,Charlotte H.

AU - Doney,Alex, S. F.

AU - Proia,Anna S.

AU - Morris,Andrew D.

AU - Gaetani,Eleonora

AU - Quarta,Miriam

AU - Smith,Roy C.

AU - Pola,Roberto

PY - 2010/11

Y1 - 2010/11

N2 - <p>OBJECTIVE-We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke. Here we tested the ability of this multigenic model to predict stroke risk in a large population-based prospective cohort of subjects with type 2 diabetes.</p><p>RESEARCH DESIGN AND METHODS This study was conducted using a prospective cohort of individuals with type 2 diabetes participating in the Go-DARTS (Genetics of Diabetes Audit and Research in Tayside Scotland) study, which includes genetic and clinical information of patients with diabetes within the Tayside region of Scotland, U.K. The above-mentioned inflammatory SNPs were investigated in 2,182 Go-DARTS participants. We created an inflammatory risk score (IRS), ranging from 0 to 5, according to the number of "at-risk" genotypes concomitantly carried by a given individual. The primary outcome was the occurrence of fatal or nonfatal stroke of any kind. Mean follow-up time was 6.2 +/- 1.1 years.</p><p>RESULTS The incidence of stroke increased according to the IRS. The IRS was significantly and independently associated with increased stroke risk after adjustment for other conventional risk factors (hazard ratio 1.34 [95% CI 1.1-1.7]; P = 0.009). The highest hazard ratio for stroke was found in subjects concomitantly carrying &gt;3 proinflammatory variations and in subjects without previous cardiovascular diseases.</p><p>CONCLUSIONS This large prospective cohort study provides evidence that SNPs of genes encoding prototypical inflammatory molecules may be used to create multigenic models that predict stroke risk in subjects with type 2 diabetes. Diabetes 59: 2945-2948, 2010</p>

AB - <p>OBJECTIVE-We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke. Here we tested the ability of this multigenic model to predict stroke risk in a large population-based prospective cohort of subjects with type 2 diabetes.</p><p>RESEARCH DESIGN AND METHODS This study was conducted using a prospective cohort of individuals with type 2 diabetes participating in the Go-DARTS (Genetics of Diabetes Audit and Research in Tayside Scotland) study, which includes genetic and clinical information of patients with diabetes within the Tayside region of Scotland, U.K. The above-mentioned inflammatory SNPs were investigated in 2,182 Go-DARTS participants. We created an inflammatory risk score (IRS), ranging from 0 to 5, according to the number of "at-risk" genotypes concomitantly carried by a given individual. The primary outcome was the occurrence of fatal or nonfatal stroke of any kind. Mean follow-up time was 6.2 +/- 1.1 years.</p><p>RESULTS The incidence of stroke increased according to the IRS. The IRS was significantly and independently associated with increased stroke risk after adjustment for other conventional risk factors (hazard ratio 1.34 [95% CI 1.1-1.7]; P = 0.009). The highest hazard ratio for stroke was found in subjects concomitantly carrying &gt;3 proinflammatory variations and in subjects without previous cardiovascular diseases.</p><p>CONCLUSIONS This large prospective cohort study provides evidence that SNPs of genes encoding prototypical inflammatory molecules may be used to create multigenic models that predict stroke risk in subjects with type 2 diabetes. Diabetes 59: 2945-2948, 2010</p>

KW - REGULATORY REGION

KW - EXPRESSION

KW - DISEASE

KW - INTERLEUKIN-6

KW - TRANSCRIPTION

KW - ASSOCIATION

KW - INVOLVEMENT

KW - PROTEIN-1

KW - MORTALITY

KW - CYTOKINES

U2 - 10.2337/db09-1690

DO - 10.2337/db09-1690

M1 - Article

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 11

VL - 59

SP - 2945

EP - 2948

ER -

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