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Common variants at 12q15 and 12q24 are associated with infant head circumference

Common variants at 12q15 and 12q24 are associated with infant head circumference

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Authors

  • H. Rob Taal
  • Beate St Pourcain
  • Elisabeth Thiering
  • Shikta Das
  • Dennis O. Mook-Kanamori
  • Nicole M. Warrington
  • Marika Kaakinen
  • Eskil Kreiner-Moller
  • Jonathan P. Bradfield
  • Rachel M. Freathy
  • Frank Geller
  • Monica Guxens
  • Diana L. Cousminer
  • Marjan Kerkhof
  • Nicholas J. Timpson
  • M. Arfan Ikram
  • Lawrence J. Beilin
  • Klaus Bonnelykke
  • Jessica L. Buxton
  • Pimphen Charoen
  • And 275 others
  • Bo Lund Krogsgaard Chawes
  • Johan Eriksson
  • David M. Evans
  • Albert Hofman
  • John P. Kemp
  • Cecilia E. Kim
  • Norman Klopp
  • Jari Lahti
  • Stephen J. Lye
  • George McMahon
  • Frank D. Mentch
  • Martina Mueller-Nurasyid
  • Paul F. O'Reilly
  • Inga Prokopenko
  • Fernando Rivadeneira
  • Eric A. P. Steegers
  • Jordi Sunyer
  • Carla Tiesler
  • Hanieh Yaghootkar
  • Monique M. B. Breteler
  • Stephanie Debette
  • Myriam Fornage
  • Vilmundur Gudnason
  • Lenore J. Launer
  • Aad van der Lugt
  • Thomas H. Mosley
  • Sudha Seshadri
  • Albert V. Smith
  • Meike W. Vernooij
  • Alexandra I. F. Blakemore
  • Rosetta M. Chiavacci
  • Bjarke Feenstra
  • Julio Fernandez-Banet
  • Struan F. A. Grant
  • Anna-Liisa Hartikainen
  • Albert J. van der Heijden
  • Carmen Iniguez
  • Mark Lathrop
  • Wendy L. McArdle
  • Anne Molgaard
  • John P. Newnham
  • Lyle J. Palmer
  • Aarno Palotie
  • Annneli Pouta
  • Susan M. Ring
  • Ulla Sovio
  • Marie Standl
  • Andre G. Uitterlinden
  • H-Erich Wichmann
  • Nadja Hawwa Vissing
  • Charles DeCarli
  • Cornelia M. van Duijn
  • Mark I. McCarthy
  • Gerard H. Koppelman
  • Xavier Estivill
  • Andrew T. Hattersley
  • Mads Melbye
  • Hans Bisgaard
  • Craig E. Pennell
  • Elisabeth Widen
  • Hakon Hakonarson
  • George Davey Smith
  • Joachim Heinrich
  • Marjo-Riitta Jarvelin
  • Vincent W. V. Jaddoe
  • Linda S. Adair
  • Wei Ang
  • Mustafa Atalay
  • Toos van Beijsterveldt
  • Nienke Bergen
  • Kelly Benke
  • Diane Berry
  • Jonathan P. Bradfield
  • Pimphen Charoen
  • Lachlan Coin
  • Diana L. Cousminer
  • Shikta Das
  • Oliver S. P. Davis
  • Paul Elliott
  • David M. Evans
  • Bjarke Feenstra
  • Claudia Flexeder
  • Tim Frayling
  • Rachel M. Freathy
  • Romy Gaillard
  • Frank Geller
  • Maria Groen-Blokhuis
  • Liang-Kee Goh
  • Monica Guxens
  • Claire M. A. Haworth
  • Dexter Hadley
  • Johannes Hedebrand
  • Anke Hinney
  • Joel N. Hirschhorn
  • John W. Holloway
  • Claus Holst
  • Jouke Jan Hottenga
  • Momoko Horikoshi
  • Ville Huikari
  • Elina Hypponen
  • Carmen Iniguez
  • Marika Kaakinen
  • Tuomas O. Kilpelainen
  • Mirna Kirin
  • Matthew Kowgier
  • Hanna-Maaria Lakka
  • Leslie A. Lange
  • Debbie A. Lawlor
  • Terho Lehtimaki
  • Alex Lewin
  • Cecilia Lindgren
  • Virpi Lindi
  • Reedik Maggi
  • Julie Marsh
  • Christel Middeldorp
  • Iona Millwood
  • Dennis O. Mook-Kanamori
  • Jeffrey C. Murray
  • Michel Nivard
  • Ellen Aagaard Nohr
  • Ioanna Ntalla
  • Emily Oken
  • Paul F. O'Reilly
  • Lyle J. Palmer
  • Kalliope Panoutsopoulou
  • Jennifer Pararajasingham
  • Inga Prokopenko
  • Alina Rodriguez
  • Rany M. Salem
  • Sylvain Sebert
  • Niina Siitonen
  • Ulla Sovio
  • Beate St Pourcain
  • David P. Strachan
  • Jordi Sunyer
  • H. Rob Taal
  • Yik-Ying Teo
  • Elisabeth Thiering
  • Carla Tiesler
  • Andre G. Uitterlinden
  • Beatriz Valcarcel
  • Nicole M. Warrington
  • Scott White
  • Gonneke Willemsen
  • Hanieh Yaghootkar
  • Eleftheria Zeggini
  • Dorret I. Boomsma
  • Cyrus Cooper
  • Xavier Estivill
  • Matthew Gillman
  • Struan F. A. Grant
  • Hakon Hakonarson
  • Andrew T. Hattersley
  • Joachim Heinrich
  • Berthold Hocher
  • Vincent W. V. Jaddoe
  • Marjo-Riitta Jarvelin
  • Timo A. Lakka
  • Mark I. McCarthy
  • Mads Melbye
  • Karen L. Mohlke
  • George V. Dedoussis
  • Ken K. Ong
  • Ewan R. Pearson
  • Craig E. Pennell
  • Thomas S. Price
  • Chris Power
  • Olli T. Raitakari
  • Seang-Mei Saw
  • Andre Scherag
  • Olli Simell
  • Thorkild I. A. Sorensen
  • Nicholas J. Timpson
  • Elisabeth Widen
  • James F. Wilson
  • Wei Ang
  • Toos van Beijsterveldt
  • Nienke Bergen
  • Kelly Benke
  • Diane Berry
  • Jonathan P. Bradfield
  • Pimphen Charoen
  • Lachlan Coin
  • Diana L. Cousminer
  • Shikta Das
  • Paul Elliott
  • David M. Evans
  • Tim Frayling
  • Rachel M. Freathy
  • Romy Gaillard
  • Maria Groen-Blokhuis
  • Monica Guxens
  • Dexter Hadley
  • Jouke Jan Hottenga
  • Ville Huikari
  • Elina Hypponen
  • Marika Kaakinen
  • Matthew Kowgier
  • Debbie A. Lawlor
  • Alex Lewin
  • Cecilia Lindgren
  • Julie Marsh
  • Christel Middeldorp
  • Iona Millwood
  • Dennis O. Mook-Kanamori
  • Michel Nivard
  • Paul F. O'Reilly
  • Lyle J. Palmer
  • Inga Prokopenko
  • Alina Rodriguez
  • Sylvain Sebert
  • Ulla Sovio
  • Beate St Pourcain
  • Marie Standl
  • David P. Strachan
  • Jordi Sunyer
  • H. Rob Taal
  • Elisabeth Thiering
  • Carla Tiesler
  • Andre G. Uitterlinden
  • Beatriz Valcarcel
  • Nicole M. Warrington
  • Scott White
  • Gonneke Willemsen
  • Hanieh Yaghootkar
  • Dorret I. Boomsma
  • Xavier Estivill
  • Struan F. A. Grant
  • Hakon Hakonarson
  • Andrew T. Hattersley
  • Joachim Heinrich
  • Vincent W. V. Jaddoe
  • Marjo-Riitta Jarvelin
  • Mark I. McCarthy
  • Craig E. Pennell
  • Chris Power
  • Nicholas J. Timpson
  • Elisabeth Widen
  • M. Arfan Ikram
  • Myriam Fornage
  • Albert V. Smith
  • Sudha Seshadri
  • Reinhold Schmidt
  • Stephanie Debette
  • Henri A. Vrooman
  • Sigurdur Sigurdsson
  • Stefan Ropele
  • Laura H. Coker
  • W. T. Longstreth
  • Wiro J. Niessen
  • Anita L. DeStefano
  • Alexa Beiser
  • Alex P. Zijdenbos
  • Maksim Struchalin
  • Clifford R. Jack
  • Mike A. Nalls
  • Rhoda Au
  • Albert Hofman
  • Haukur Gudnason
  • Aad van der Lugt
  • Tamara B. Harris
  • William M. Meeks
  • Meike W. Vernooij
  • Mark A. van Buchem
  • Diane Catellier
  • Vilmundur Gudnason
  • B. Gwen Windham
  • Philip A. Wolf
  • Cornelia M. van Duijn
  • Thomas H. Mosley
  • Helena Schmidt
  • Lenore J. Launer
  • Monique M. B. Breteler
  • Charles DeCarli
  • Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genetic Ep

Research units

Info

Original languageEnglish
Pages532-538
Number of pages9
JournalNature Genetics
Journal publication dateMay 2012
Volume44
Issue5
DOIs
StatePublished

Abstract

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.</p>

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