TY  - JOUR
T1  - Common variants at 12q15 and 12q24 are associated with infant head circumference
A1  - Taal,H. Rob
A1  - St Pourcain,Beate
A1  - Thiering,Elisabeth
A1  - Das,Shikta
A1  - Mook-Kanamori,Dennis O.
A1  - Warrington,Nicole M.
A1  - Kaakinen,Marika
A1  - Kreiner-Moller,Eskil
A1  - Bradfield,Jonathan P.
A1  - Freathy,Rachel M.
A1  - Geller,Frank
A1  - Guxens,Monica
A1  - Cousminer,Diana L.
A1  - Kerkhof,Marjan
A1  - Timpson,Nicholas J.
A1  - Ikram,M. Arfan
A1  - Beilin,Lawrence J.
A1  - Bonnelykke,Klaus
A1  - Buxton,Jessica L.
A1  - Charoen,Pimphen
A1  - Chawes,Bo Lund Krogsgaard
A1  - Eriksson,Johan
A1  - Evans,David M.
A1  - Hofman,Albert
A1  - Kemp,John P.
A1  - Kim,Cecilia E.
A1  - Klopp,Norman
A1  - Lahti,Jari
A1  - Lye,Stephen J.
A1  - McMahon,George
A1  - Mentch,Frank D.
A1  - Mueller-Nurasyid,Martina
A1  - O'Reilly,Paul F.
A1  - Prokopenko,Inga
A1  - Rivadeneira,Fernando
A1  - Steegers,Eric A. P.
A1  - Sunyer,Jordi
A1  - Tiesler,Carla
A1  - Yaghootkar,Hanieh
A1  - Breteler,Monique M. B.
A1  - Debette,Stephanie
A1  - Fornage,Myriam
A1  - Gudnason,Vilmundur
A1  - Launer,Lenore J.
A1  - van der Lugt,Aad
A1  - Mosley,Thomas H.
A1  - Seshadri,Sudha
A1  - Smith,Albert V.
A1  - Vernooij,Meike W.
A1  - Blakemore,Alexandra I. F.
A1  - Chiavacci,Rosetta M.
A1  - Feenstra,Bjarke
A1  - Fernandez-Banet,Julio
A1  - Grant,Struan F. A.
A1  - Hartikainen,Anna-Liisa
A1  - van der Heijden,Albert J.
A1  - Iniguez,Carmen
A1  - Lathrop,Mark
A1  - McArdle,Wendy L.
A1  - Molgaard,Anne
A1  - Newnham,John P.
A1  - Palmer,Lyle J.
A1  - Palotie,Aarno
A1  - Pouta,Annneli
A1  - Ring,Susan M.
A1  - Sovio,Ulla
A1  - Standl,Marie
A1  - Uitterlinden,Andre G.
A1  - Wichmann,H-Erich
A1  - Vissing,Nadja Hawwa
A1  - DeCarli,Charles
A1  - van Duijn,Cornelia M.
A1  - McCarthy,Mark I.
A1  - Koppelman,Gerard H.
A1  - Estivill,Xavier
A1  - Hattersley,Andrew T.
A1  - Melbye,Mads
A1  - Bisgaard,Hans
A1  - Pennell,Craig E.
A1  - Widen,Elisabeth
A1  - Hakonarson,Hakon
A1  - Smith,George Davey
A1  - Heinrich,Joachim
A1  - Jarvelin,Marjo-Riitta
A1  - Jaddoe,Vincent W. V.
A1  - Adair,Linda S.
A1  - Ang,Wei
A1  - Atalay,Mustafa
A1  - van Beijsterveldt,Toos
A1  - Bergen,Nienke
A1  - Benke,Kelly
A1  - Berry,Diane
A1  - Coin,Lachlan
A1  - Davis,Oliver S. P.
A1  - Elliott,Paul
A1  - Flexeder,Claudia
A1  - Frayling,Tim
A1  - Gaillard,Romy
A1  - Groen-Blokhuis,Maria
A1  - Goh,Liang-Kee
A1  - Haworth,Claire M. A.
A1  - Hadley,Dexter
A1  - Hedebrand,Johannes
A1  - Hinney,Anke
A1  - Hirschhorn,Joel N.
A1  - Holloway,John W.
A1  - Holst,Claus
A1  - Hottenga,Jouke Jan
A1  - Horikoshi,Momoko
A1  - Huikari,Ville
A1  - Hypponen,Elina
A1  - Kilpelainen,Tuomas O.
A1  - Kirin,Mirna
A1  - Kowgier,Matthew
A1  - Lakka,Hanna-Maaria
A1  - Lange,Leslie A.
A1  - Lawlor,Debbie A.
A1  - Lehtimaki,Terho
A1  - Lewin,Alex
A1  - Lindgren,Cecilia
A1  - Lindi,Virpi
A1  - Maggi,Reedik
A1  - Marsh,Julie
A1  - Middeldorp,Christel
A1  - Millwood,Iona
A1  - Murray,Jeffrey C.
A1  - Nivard,Michel
A1  - Nohr,Ellen Aagaard
A1  - Ntalla,Ioanna
A1  - Oken,Emily
A1  - Panoutsopoulou,Kalliope
A1  - Pararajasingham,Jennifer
A1  - Rodriguez,Alina
A1  - Salem,Rany M.
A1  - Sebert,Sylvain
A1  - Siitonen,Niina
A1  - Strachan,David P.
A1  - Teo,Yik-Ying
A1  - Valcarcel,Beatriz
A1  - White,Scott
A1  - Willemsen,Gonneke
A1  - Zeggini,Eleftheria
A1  - Boomsma,Dorret I.
A1  - Cooper,Cyrus
A1  - Gillman,Matthew
A1  - Hocher,Berthold
A1  - Lakka,Timo A.
A1  - Mohlke,Karen L.
A1  - Dedoussis,George V.
A1  - Ong,Ken K.
A1  - Pearson,Ewan R.
A1  - Price,Thomas S.
A1  - Power,Chris
A1  - Raitakari,Olli T.
A1  - Saw,Seang-Mei
A1  - Scherag,Andre
A1  - Simell,Olli
A1  - Sorensen,Thorkild I. A.
A1  - Wilson,James F.
A1  - Schmidt,Reinhold
A1  - Vrooman,Henri A.
A1  - Sigurdsson,Sigurdur
A1  - Ropele,Stefan
A1  - Coker,Laura H.
A1  - Longstreth,W. T.
A1  - Niessen,Wiro J.
A1  - DeStefano,Anita L.
A1  - Beiser,Alexa
A1  - Zijdenbos,Alex P.
A1  - Struchalin,Maksim
A1  - Jack,Clifford R.
A1  - Nalls,Mike A.
A1  - Au,Rhoda
A1  - Gudnason,Haukur
A1  - Harris,Tamara B.
A1  - Meeks,William M.
A1  - van Buchem,Mark A.
A1  - Catellier,Diane
A1  - Windham,B. Gwen
A1  - Wolf,Philip A.
A1  - Schmidt,Helena
A1  - Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genetic Ep
AU  - Taal,H. Rob
AU  - St Pourcain,Beate
AU  - Thiering,Elisabeth
AU  - Das,Shikta
AU  - Mook-Kanamori,Dennis O.
AU  - Warrington,Nicole M.
AU  - Kaakinen,Marika
AU  - Kreiner-Moller,Eskil
AU  - Bradfield,Jonathan P.
AU  - Freathy,Rachel M.
AU  - Geller,Frank
AU  - Guxens,Monica
AU  - Cousminer,Diana L.
AU  - Kerkhof,Marjan
AU  - Timpson,Nicholas J.
AU  - Ikram,M. Arfan
AU  - Beilin,Lawrence J.
AU  - Bonnelykke,Klaus
AU  - Buxton,Jessica L.
AU  - Charoen,Pimphen
AU  - Chawes,Bo Lund Krogsgaard
AU  - Eriksson,Johan
AU  - Evans,David M.
AU  - Hofman,Albert
AU  - Kemp,John P.
AU  - Kim,Cecilia E.
AU  - Klopp,Norman
AU  - Lahti,Jari
AU  - Lye,Stephen J.
AU  - McMahon,George
AU  - Mentch,Frank D.
AU  - Mueller-Nurasyid,Martina
AU  - O'Reilly,Paul F.
AU  - Prokopenko,Inga
AU  - Rivadeneira,Fernando
AU  - Steegers,Eric A. P.
AU  - Sunyer,Jordi
AU  - Tiesler,Carla
AU  - Yaghootkar,Hanieh
AU  - Breteler,Monique M. B.
AU  - Debette,Stephanie
AU  - Fornage,Myriam
AU  - Gudnason,Vilmundur
AU  - Launer,Lenore J.
AU  - van der Lugt,Aad
AU  - Mosley,Thomas H.
AU  - Seshadri,Sudha
AU  - Smith,Albert V.
AU  - Vernooij,Meike W.
AU  - Blakemore,Alexandra I. F.
AU  - Chiavacci,Rosetta M.
AU  - Feenstra,Bjarke
AU  - Fernandez-Banet,Julio
AU  - Grant,Struan F. A.
AU  - Hartikainen,Anna-Liisa
AU  - van der Heijden,Albert J.
AU  - Iniguez,Carmen
AU  - Lathrop,Mark
AU  - McArdle,Wendy L.
AU  - Molgaard,Anne
AU  - Newnham,John P.
AU  - Palmer,Lyle J.
AU  - Palotie,Aarno
AU  - Pouta,Annneli
AU  - Ring,Susan M.
AU  - Sovio,Ulla
AU  - Standl,Marie
AU  - Uitterlinden,Andre G.
AU  - Wichmann,H-Erich
AU  - Vissing,Nadja Hawwa
AU  - DeCarli,Charles
AU  - van Duijn,Cornelia M.
AU  - McCarthy,Mark I.
AU  - Koppelman,Gerard H.
AU  - Estivill,Xavier
AU  - Hattersley,Andrew T.
AU  - Melbye,Mads
AU  - Bisgaard,Hans
AU  - Pennell,Craig E.
AU  - Widen,Elisabeth
AU  - Hakonarson,Hakon
AU  - Smith,George Davey
AU  - Heinrich,Joachim
AU  - Jarvelin,Marjo-Riitta
AU  - Jaddoe,Vincent W. V.
AU  - Adair,Linda S.
AU  - Ang,Wei
AU  - Atalay,Mustafa
AU  - van Beijsterveldt,Toos
AU  - Bergen,Nienke
AU  - Benke,Kelly
AU  - Berry,Diane
AU  - Coin,Lachlan
AU  - Davis,Oliver S. P.
AU  - Elliott,Paul
AU  - Flexeder,Claudia
AU  - Frayling,Tim
AU  - Gaillard,Romy
AU  - Groen-Blokhuis,Maria
AU  - Goh,Liang-Kee
AU  - Haworth,Claire M. A.
AU  - Hadley,Dexter
AU  - Hedebrand,Johannes
AU  - Hinney,Anke
AU  - Hirschhorn,Joel N.
AU  - Holloway,John W.
AU  - Holst,Claus
AU  - Hottenga,Jouke Jan
AU  - Horikoshi,Momoko
AU  - Huikari,Ville
AU  - Hypponen,Elina
AU  - Kilpelainen,Tuomas O.
AU  - Kirin,Mirna
AU  - Kowgier,Matthew
AU  - Lakka,Hanna-Maaria
AU  - Lange,Leslie A.
AU  - Lawlor,Debbie A.
AU  - Lehtimaki,Terho
AU  - Lewin,Alex
AU  - Lindgren,Cecilia
AU  - Lindi,Virpi
AU  - Maggi,Reedik
AU  - Marsh,Julie
AU  - Middeldorp,Christel
AU  - Millwood,Iona
AU  - Murray,Jeffrey C.
AU  - Nivard,Michel
AU  - Nohr,Ellen Aagaard
AU  - Ntalla,Ioanna
AU  - Oken,Emily
AU  - Panoutsopoulou,Kalliope
AU  - Pararajasingham,Jennifer
AU  - Rodriguez,Alina
AU  - Salem,Rany M.
AU  - Sebert,Sylvain
AU  - Siitonen,Niina
AU  - Strachan,David P.
AU  - Teo,Yik-Ying
AU  - Valcarcel,Beatriz
AU  - White,Scott
AU  - Willemsen,Gonneke
AU  - Zeggini,Eleftheria
AU  - Boomsma,Dorret I.
AU  - Cooper,Cyrus
AU  - Gillman,Matthew
AU  - Hocher,Berthold
AU  - Lakka,Timo A.
AU  - Mohlke,Karen L.
AU  - Dedoussis,George V.
AU  - Ong,Ken K.
AU  - Pearson,Ewan R.
AU  - Price,Thomas S.
AU  - Power,Chris
AU  - Raitakari,Olli T.
AU  - Saw,Seang-Mei
AU  - Scherag,Andre
AU  - Simell,Olli
AU  - Sorensen,Thorkild I. A.
AU  - Wilson,James F.
AU  - Schmidt,Reinhold
AU  - Vrooman,Henri A.
AU  - Sigurdsson,Sigurdur
AU  - Ropele,Stefan
AU  - Coker,Laura H.
AU  - Longstreth,W. T.
AU  - Niessen,Wiro J.
AU  - DeStefano,Anita L.
AU  - Beiser,Alexa
AU  - Zijdenbos,Alex P.
AU  - Struchalin,Maksim
AU  - Jack,Clifford R.
AU  - Nalls,Mike A.
AU  - Au,Rhoda
AU  - Gudnason,Haukur
AU  - Harris,Tamara B.
AU  - Meeks,William M.
AU  - van Buchem,Mark A.
AU  - Catellier,Diane
AU  - Windham,B. Gwen
AU  - Wolf,Philip A.
AU  - Schmidt,Helena
AU  - Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genetic Ep
PY  - 2012/5
Y1  - 2012/5
N2  - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.</p>
AB  - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.</p>
U2  - 10.1038/ng.2238
DO  - 10.1038/ng.2238
M1  - Article
JO  - Nature Genetics
JF  - Nature Genetics
SN  - 1061-4036
IS  - 5
VL  - 44
SP  - 532
EP  - 538
ER  -