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Common variants at 6q22 and 17q21 are associated with intracranial volume

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Common variants at 6q22 and 17q21 are associated with intracranial volume. / Ikram, M. Arfan; Fornage, Myriam; Smith, Albert V.; Seshadri, Sudha; Schmidt, Reinhold; Debette, Stephanie; Vrooman, Henri A.; Sigurdsson, Sigurdur; Ropele, Stefan; Taal, H. Rob; Mook-Kanamori, Dennis O.; Coker, Laura H.; Longstreth, W. T.; Niessen, Wiro J.; DeStefano, Anita L.; Beiser, Alexa; Zijdenbos, Alex P.; Struchalin, Maksim; Jack, Clifford R.; Rivadeneira, Fernando; Uitterlinden, Andre G.; Knopman, David S.; Hartikainen, Anna-Liisa; Pennell, Craig E.; Thiering, Elisabeth; Steegers, Eric A. P.; Hakonarson, Hakon; Heinrich, Joachim; Palmer, Lyle J.; Jarvelin, Marjo-Riitta; McCarthy, Mark I.; Grant, Struan F. A.; St Pourcain, Beate; Timpson, Nicholas J.; Smith, George Davey; Sovio, Ulla; Nalls, Mike A.; Au, Rhoda; Hofman, Albert; Gudnason, Haukur; van der Lugt, Aad; Harris, Tamara B.; Meeks, William M.; Vernooij, Meike W.; van Buchem, Mark A.; Catellier, Diane; Jaddoe, Vincent W. V.; Gudnason, Vilmundur; Windham, B. Gwen; Wolf, Philip A.; van Duijn, Cornelia M.; Mosley, Thomas H.; Schmidt, Helena; Launer, Lenore J.; Breteler, Monique M. B.; DeCarli, Charles; Adair, Linda S.; Ang, Wei; Atalay, Mustafa; vanBeijsterveldt, Toos; Bergen, Nienke; Benke, Kelly; Berry, Diane; Coin, Lachlan; Davis, Oliver S. P.; Elliott, Paul; Flexeder, Claudia; Frayling, Tim; Gaillard, Romy; Groen-Blokhuis, Maria; Goh, Liang-Kee; Haworth, Claire M. A.; Hadley, Dexter; Hedebrand, Johannes; Hinney, Anke; Hirschhorn, Joel N.; Holloway, John W.; Holst, Claus; Hottenga, Jouke Jan; Horikoshi, Momoko; Huikari, Ville; Hypponen, Elina; Kilpelainen, Tuomas O.; Kirin, Mirna; Kowgier, Matthew; Lakka, Hanna-Maaria; Lange, Leslie A.; Lawlor, Debbie A.; Lehtimaki, Terho; Lewin, Alex; Lindgren, Cecilia; Lindi, Virpi; Maggi, Reedik; Marsh, Julie; Middeldorp, Christel; Millwood, Iona; Murray, Jeffrey C.; Nivard, Michel; Nohr, Ellen Aagaard; Ntalla, Ioanna; Oken, Emily; Panoutsopoulou, Kalliope; Pararajasingham, Jennifer; Rodriguez, Alina; Salem, Rany M.; Sebert, Sylvain; Siitonen, Niina; Strachan, David P.; Teo, Yik-Ying; Valcarcel, Beatriz; Willemsen, Gonneke; Zeggini, Eleftheria; Boomsma, Dorret I.; Cooper, Cyrus; Gillman, Matthew; Hocher, Berthold; Lakka, Timo A.; Mohlke, Karen L.; Dedoussis, George V.; Ong, Ken K.; Pearson, Ewan R.; Price, Thomas S.; Power, Chris; Raitakari, Olli T.; Saw, Seang-Mei; Scherag, Andre; Simell, Olli; Sorensen, Thorkild I. A.; Wilson, James F.; Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep.

In: Nature Genetics, Vol. 44, No. 5, 05.2012, p. 539-544.

Research output: Contribution to journalArticle

Harvard

Ikram, MA, Fornage, M, Smith, AV, Seshadri, S, Schmidt, R, Debette, S, Vrooman, HA, Sigurdsson, S, Ropele, S, Taal, HR, Mook-Kanamori, DO, Coker, LH, Longstreth, WT, Niessen, WJ, DeStefano, AL, Beiser, A, Zijdenbos, AP, Struchalin, M, Jack, CR, Rivadeneira, F, Uitterlinden, AG, Knopman, DS, Hartikainen, A-L, Pennell, CE, Thiering, E, Steegers, EAP, Hakonarson, H, Heinrich, J, Palmer, LJ, Jarvelin, M-R, McCarthy, MI, Grant, SFA, St Pourcain, B, Timpson, NJ, Smith, GD, Sovio, U, Nalls, MA, Au, R, Hofman, A, Gudnason, H, van der Lugt, A, Harris, TB, Meeks, WM, Vernooij, MW, van Buchem, MA, Catellier, D, Jaddoe, VWV, Gudnason, V, Windham, BG, Wolf, PA, van Duijn, CM, Mosley, TH, Schmidt, H, Launer, LJ, Breteler, MMB, DeCarli, C, Adair, LS, Ang, W, Atalay, M, vanBeijsterveldt, T, Bergen, N, Benke, K, Berry, D, Coin, L, Davis, OSP, Elliott, P, Flexeder, C, Frayling, T, Gaillard, R, Groen-Blokhuis, M, Goh, L-K, Haworth, CMA, Hadley, D, Hedebrand, J, Hinney, A, Hirschhorn, JN, Holloway, JW, Holst, C, Hottenga, JJ, Horikoshi, M, Huikari, V, Hypponen, E, Kilpelainen, TO, Kirin, M, Kowgier, M, Lakka, H-M, Lange, LA, Lawlor, DA, Lehtimaki, T, Lewin, A, Lindgren, C, Lindi, V, Maggi, R, Marsh, J, Middeldorp, C, Millwood, I, Murray, JC, Nivard, M, Nohr, EA, Ntalla, I, Oken, E, Panoutsopoulou, K, Pararajasingham, J, Rodriguez, A, Salem, RM, Sebert, S, Siitonen, N, Strachan, DP, Teo, Y-Y, Valcarcel, B, Willemsen, G, Zeggini, E, Boomsma, DI, Cooper, C, Gillman, M, Hocher, B, Lakka, TA, Mohlke, KL, Dedoussis, GV, Ong, KK, Pearson, ER, Price, TS, Power, C, Raitakari, OT, Saw, S-M, Scherag, A, Simell, O, Sorensen, TIA, Wilson, JF & Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep 2012, 'Common variants at 6q22 and 17q21 are associated with intracranial volume' Nature Genetics, vol 44, no. 5, pp. 539-544.

APA

Ikram, M. A., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, W. T., Niessen, W. J., DeStefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., Rivadeneira, F., Uitterlinden, A. G., Knopman, D. S., Hartikainen, A-L., Pennell, C. E., Thiering, E., Steegers, E. A. P., Hakonarson, H., Heinrich, J., Palmer, L. J., Jarvelin, M-R., McCarthy, M. I., Grant, S. F. A., St Pourcain, B., Timpson, N. J., Smith, G. D., Sovio, U., Nalls, M. A., Au, R., Hofman, A., Gudnason, H., van der Lugt, A., Harris, T. B., Meeks, W. M., Vernooij, M. W., van Buchem, M. A., Catellier, D., Jaddoe, V. W. V., Gudnason, V., Windham, B. G., Wolf, P. A., van Duijn, C. M., Mosley, T. H., Schmidt, H., Launer, L. J., Breteler, M. M. B., DeCarli, C., Adair, L. S., Ang, W., Atalay, M., vanBeijsterveldt, T., Bergen, N., Benke, K., Berry, D., Coin, L., Davis, O. S. P., Elliott, P., Flexeder, C., Frayling, T., Gaillard, R., Groen-Blokhuis, M., Goh, L-K., Haworth, C. M. A., Hadley, D., Hedebrand, J., Hinney, A., Hirschhorn, J. N., Holloway, J. W., Holst, C., Hottenga, J. J., Horikoshi, M., Huikari, V., Hypponen, E., Kilpelainen, T. O., Kirin, M., Kowgier, M., Lakka, H-M., Lange, L. A., Lawlor, D. A., Lehtimaki, T., Lewin, A., Lindgren, C., Lindi, V., Maggi, R., Marsh, J., Middeldorp, C., Millwood, I., Murray, J. C., Nivard, M., Nohr, E. A., Ntalla, I., Oken, E., Panoutsopoulou, K., Pararajasingham, J., Rodriguez, A., Salem, R. M., Sebert, S., Siitonen, N., Strachan, D. P., Teo, Y-Y., Valcarcel, B., Willemsen, G., Zeggini, E., Boomsma, D. I., Cooper, C., Gillman, M., Hocher, B., Lakka, T. A., Mohlke, K. L., Dedoussis, G. V., Ong, K. K., Pearson, E. R., Price, T. S., Power, C., Raitakari, O. T., Saw, S-M., Scherag, A., Simell, O., Sorensen, T. I. A., Wilson, J. F., & Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44(5), 539-544doi: 10.1038/ng.2245

Vancouver

Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S et al. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics. 2012 May;44(5):539-544.

Author

Ikram, M. Arfan; Fornage, Myriam; Smith, Albert V.; Seshadri, Sudha; Schmidt, Reinhold; Debette, Stephanie; Vrooman, Henri A.; Sigurdsson, Sigurdur; Ropele, Stefan; Taal, H. Rob; Mook-Kanamori, Dennis O.; Coker, Laura H.; Longstreth, W. T.; Niessen, Wiro J.; DeStefano, Anita L.; Beiser, Alexa; Zijdenbos, Alex P.; Struchalin, Maksim; Jack, Clifford R.; Rivadeneira, Fernando; Uitterlinden, Andre G.; Knopman, David S.; Hartikainen, Anna-Liisa; Pennell, Craig E.; Thiering, Elisabeth; Steegers, Eric A. P.; Hakonarson, Hakon; Heinrich, Joachim; Palmer, Lyle J.; Jarvelin, Marjo-Riitta; McCarthy, Mark I.; Grant, Struan F. A.; St Pourcain, Beate; Timpson, Nicholas J.; Smith, George Davey; Sovio, Ulla; Nalls, Mike A.; Au, Rhoda; Hofman, Albert; Gudnason, Haukur; van der Lugt, Aad; Harris, Tamara B.; Meeks, William M.; Vernooij, Meike W.; van Buchem, Mark A.; Catellier, Diane; Jaddoe, Vincent W. V.; Gudnason, Vilmundur; Windham, B. Gwen; Wolf, Philip A.; van Duijn, Cornelia M.; Mosley, Thomas H.; Schmidt, Helena; Launer, Lenore J.; Breteler, Monique M. B.; DeCarli, Charles; Adair, Linda S.; Ang, Wei; Atalay, Mustafa; vanBeijsterveldt, Toos; Bergen, Nienke; Benke, Kelly; Berry, Diane; Coin, Lachlan; Davis, Oliver S. P.; Elliott, Paul; Flexeder, Claudia; Frayling, Tim; Gaillard, Romy; Groen-Blokhuis, Maria; Goh, Liang-Kee; Haworth, Claire M. A.; Hadley, Dexter; Hedebrand, Johannes; Hinney, Anke; Hirschhorn, Joel N.; Holloway, John W.; Holst, Claus; Hottenga, Jouke Jan; Horikoshi, Momoko; Huikari, Ville; Hypponen, Elina; Kilpelainen, Tuomas O.; Kirin, Mirna; Kowgier, Matthew; Lakka, Hanna-Maaria; Lange, Leslie A.; Lawlor, Debbie A.; Lehtimaki, Terho; Lewin, Alex; Lindgren, Cecilia; Lindi, Virpi; Maggi, Reedik; Marsh, Julie; Middeldorp, Christel; Millwood, Iona; Murray, Jeffrey C.; Nivard, Michel; Nohr, Ellen Aagaard; Ntalla, Ioanna; Oken, Emily; Panoutsopoulou, Kalliope; Pararajasingham, Jennifer; Rodriguez, Alina; Salem, Rany M.; Sebert, Sylvain; Siitonen, Niina; Strachan, David P.; Teo, Yik-Ying; Valcarcel, Beatriz; Willemsen, Gonneke; Zeggini, Eleftheria; Boomsma, Dorret I.; Cooper, Cyrus; Gillman, Matthew; Hocher, Berthold; Lakka, Timo A.; Mohlke, Karen L.; Dedoussis, George V.; Ong, Ken K.; Pearson, Ewan R.; Price, Thomas S.; Power, Chris; Raitakari, Olli T.; Saw, Seang-Mei; Scherag, Andre; Simell, Olli; Sorensen, Thorkild I. A.; Wilson, James F.; Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep / Common variants at 6q22 and 17q21 are associated with intracranial volume.

In: Nature Genetics, Vol. 44, No. 5, 05.2012, p. 539-544.

Research output: Contribution to journalArticle

Bibtex - Download

@article{9b1bce763e9c4bbc8c684929b0b8d852,
title = "Common variants at 6q22 and 17q21 are associated with intracranial volume",
author = "Ikram, {M. Arfan} and Myriam Fornage and Smith, {Albert V.} and Sudha Seshadri and Reinhold Schmidt and Stephanie Debette and Vrooman, {Henri A.} and Sigurdur Sigurdsson and Stefan Ropele and Taal, {H. Rob} and Mook-Kanamori, {Dennis O.} and Coker, {Laura H.} and Longstreth, {W. T.} and Niessen, {Wiro J.} and DeStefano, {Anita L.} and Alexa Beiser and Zijdenbos, {Alex P.} and Maksim Struchalin and Jack, {Clifford R.} and Fernando Rivadeneira and Uitterlinden, {Andre G.} and Knopman, {David S.} and Anna-Liisa Hartikainen and Pennell, {Craig E.} and Elisabeth Thiering and Steegers, {Eric A. P.} and Hakon Hakonarson and Joachim Heinrich and Palmer, {Lyle J.} and Marjo-Riitta Jarvelin and McCarthy, {Mark I.} and Grant, {Struan F. A.} and {St Pourcain}, Beate and Timpson, {Nicholas J.} and Smith, {George Davey} and Ulla Sovio and Nalls, {Mike A.} and Rhoda Au and Albert Hofman and Haukur Gudnason and {van der Lugt}, Aad and Harris, {Tamara B.} and Meeks, {William M.} and Vernooij, {Meike W.} and {van Buchem}, {Mark A.} and Diane Catellier and Jaddoe, {Vincent W. V.} and Vilmundur Gudnason and Windham, {B. Gwen} and Wolf, {Philip A.} and {van Duijn}, {Cornelia M.} and Mosley, {Thomas H.} and Helena Schmidt and Launer, {Lenore J.} and Breteler, {Monique M. B.} and Charles DeCarli and Adair, {Linda S.} and Wei Ang and Mustafa Atalay and Toos vanBeijsterveldt and Nienke Bergen and Kelly Benke and Diane Berry and Lachlan Coin and Davis, {Oliver S. P.} and Paul Elliott and Claudia Flexeder and Tim Frayling and Romy Gaillard and Maria Groen-Blokhuis and Liang-Kee Goh and Haworth, {Claire M. A.} and Dexter Hadley and Johannes Hedebrand and Anke Hinney and Hirschhorn, {Joel N.} and Holloway, {John W.} and Claus Holst and Hottenga, {Jouke Jan} and Momoko Horikoshi and Ville Huikari and Elina Hypponen and Kilpelainen, {Tuomas O.} and Mirna Kirin and Matthew Kowgier and Hanna-Maaria Lakka and Lange, {Leslie A.} and Lawlor, {Debbie A.} and Terho Lehtimaki and Alex Lewin and Cecilia Lindgren and Virpi Lindi and Reedik Maggi and Julie Marsh and Christel Middeldorp and Iona Millwood and Murray, {Jeffrey C.} and Michel Nivard and Nohr, {Ellen Aagaard} and Ioanna Ntalla and Emily Oken and Kalliope Panoutsopoulou and Jennifer Pararajasingham and Alina Rodriguez and Salem, {Rany M.} and Sylvain Sebert and Niina Siitonen and Strachan, {David P.} and Yik-Ying Teo and Beatriz Valcarcel and Gonneke Willemsen and Eleftheria Zeggini and Boomsma, {Dorret I.} and Cyrus Cooper and Matthew Gillman and Berthold Hocher and Lakka, {Timo A.} and Mohlke, {Karen L.} and Dedoussis, {George V.} and Ong, {Ken K.} and Pearson, {Ewan R.} and Price, {Thomas S.} and Chris Power and Raitakari, {Olli T.} and Seang-Mei Saw and Andre Scherag and Olli Simell and Sorensen, {Thorkild I. A.} and Wilson, {James F.} and {Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep}",
year = "2012",
volume = "44",
number = "5",
pages = "539--544",
journal = "Nature Genetics",
issn = "1061-4036",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Common variants at 6q22 and 17q21 are associated with intracranial volume

A1 - Ikram,M. Arfan

A1 - Fornage,Myriam

A1 - Smith,Albert V.

A1 - Seshadri,Sudha

A1 - Schmidt,Reinhold

A1 - Debette,Stephanie

A1 - Vrooman,Henri A.

A1 - Sigurdsson,Sigurdur

A1 - Ropele,Stefan

A1 - Taal,H. Rob

A1 - Mook-Kanamori,Dennis O.

A1 - Coker,Laura H.

A1 - Longstreth,W. T.

A1 - Niessen,Wiro J.

A1 - DeStefano,Anita L.

A1 - Beiser,Alexa

A1 - Zijdenbos,Alex P.

A1 - Struchalin,Maksim

A1 - Jack,Clifford R.

A1 - Rivadeneira,Fernando

A1 - Uitterlinden,Andre G.

A1 - Knopman,David S.

A1 - Hartikainen,Anna-Liisa

A1 - Pennell,Craig E.

A1 - Thiering,Elisabeth

A1 - Steegers,Eric A. P.

A1 - Hakonarson,Hakon

A1 - Heinrich,Joachim

A1 - Palmer,Lyle J.

A1 - Jarvelin,Marjo-Riitta

A1 - McCarthy,Mark I.

A1 - Grant,Struan F. A.

A1 - St Pourcain,Beate

A1 - Timpson,Nicholas J.

A1 - Smith,George Davey

A1 - Sovio,Ulla

A1 - Nalls,Mike A.

A1 - Au,Rhoda

A1 - Hofman,Albert

A1 - Gudnason,Haukur

A1 - van der Lugt,Aad

A1 - Harris,Tamara B.

A1 - Meeks,William M.

A1 - Vernooij,Meike W.

A1 - van Buchem,Mark A.

A1 - Catellier,Diane

A1 - Jaddoe,Vincent W. V.

A1 - Gudnason,Vilmundur

A1 - Windham,B. Gwen

A1 - Wolf,Philip A.

A1 - van Duijn,Cornelia M.

A1 - Mosley,Thomas H.

A1 - Schmidt,Helena

A1 - Launer,Lenore J.

A1 - Breteler,Monique M. B.

A1 - DeCarli,Charles

A1 - Adair,Linda S.

A1 - Ang,Wei

A1 - Atalay,Mustafa

A1 - vanBeijsterveldt,Toos

A1 - Bergen,Nienke

A1 - Benke,Kelly

A1 - Berry,Diane

A1 - Coin,Lachlan

A1 - Davis,Oliver S. P.

A1 - Elliott,Paul

A1 - Flexeder,Claudia

A1 - Frayling,Tim

A1 - Gaillard,Romy

A1 - Groen-Blokhuis,Maria

A1 - Goh,Liang-Kee

A1 - Haworth,Claire M. A.

A1 - Hadley,Dexter

A1 - Hedebrand,Johannes

A1 - Hinney,Anke

A1 - Hirschhorn,Joel N.

A1 - Holloway,John W.

A1 - Holst,Claus

A1 - Hottenga,Jouke Jan

A1 - Horikoshi,Momoko

A1 - Huikari,Ville

A1 - Hypponen,Elina

A1 - Kilpelainen,Tuomas O.

A1 - Kirin,Mirna

A1 - Kowgier,Matthew

A1 - Lakka,Hanna-Maaria

A1 - Lange,Leslie A.

A1 - Lawlor,Debbie A.

A1 - Lehtimaki,Terho

A1 - Lewin,Alex

A1 - Lindgren,Cecilia

A1 - Lindi,Virpi

A1 - Maggi,Reedik

A1 - Marsh,Julie

A1 - Middeldorp,Christel

A1 - Millwood,Iona

A1 - Murray,Jeffrey C.

A1 - Nivard,Michel

A1 - Nohr,Ellen Aagaard

A1 - Ntalla,Ioanna

A1 - Oken,Emily

A1 - Panoutsopoulou,Kalliope

A1 - Pararajasingham,Jennifer

A1 - Rodriguez,Alina

A1 - Salem,Rany M.

A1 - Sebert,Sylvain

A1 - Siitonen,Niina

A1 - Strachan,David P.

A1 - Teo,Yik-Ying

A1 - Valcarcel,Beatriz

A1 - Willemsen,Gonneke

A1 - Zeggini,Eleftheria

A1 - Boomsma,Dorret I.

A1 - Cooper,Cyrus

A1 - Gillman,Matthew

A1 - Hocher,Berthold

A1 - Lakka,Timo A.

A1 - Mohlke,Karen L.

A1 - Dedoussis,George V.

A1 - Ong,Ken K.

A1 - Pearson,Ewan R.

A1 - Price,Thomas S.

A1 - Power,Chris

A1 - Raitakari,Olli T.

A1 - Saw,Seang-Mei

A1 - Scherag,Andre

A1 - Simell,Olli

A1 - Sorensen,Thorkild I. A.

A1 - Wilson,James F.

A1 - Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep

AU - Ikram,M. Arfan

AU - Fornage,Myriam

AU - Smith,Albert V.

AU - Seshadri,Sudha

AU - Schmidt,Reinhold

AU - Debette,Stephanie

AU - Vrooman,Henri A.

AU - Sigurdsson,Sigurdur

AU - Ropele,Stefan

AU - Taal,H. Rob

AU - Mook-Kanamori,Dennis O.

AU - Coker,Laura H.

AU - Longstreth,W. T.

AU - Niessen,Wiro J.

AU - DeStefano,Anita L.

AU - Beiser,Alexa

AU - Zijdenbos,Alex P.

AU - Struchalin,Maksim

AU - Jack,Clifford R.

AU - Rivadeneira,Fernando

AU - Uitterlinden,Andre G.

AU - Knopman,David S.

AU - Hartikainen,Anna-Liisa

AU - Pennell,Craig E.

AU - Thiering,Elisabeth

AU - Steegers,Eric A. P.

AU - Hakonarson,Hakon

AU - Heinrich,Joachim

AU - Palmer,Lyle J.

AU - Jarvelin,Marjo-Riitta

AU - McCarthy,Mark I.

AU - Grant,Struan F. A.

AU - St Pourcain,Beate

AU - Timpson,Nicholas J.

AU - Smith,George Davey

AU - Sovio,Ulla

AU - Nalls,Mike A.

AU - Au,Rhoda

AU - Hofman,Albert

AU - Gudnason,Haukur

AU - van der Lugt,Aad

AU - Harris,Tamara B.

AU - Meeks,William M.

AU - Vernooij,Meike W.

AU - van Buchem,Mark A.

AU - Catellier,Diane

AU - Jaddoe,Vincent W. V.

AU - Gudnason,Vilmundur

AU - Windham,B. Gwen

AU - Wolf,Philip A.

AU - van Duijn,Cornelia M.

AU - Mosley,Thomas H.

AU - Schmidt,Helena

AU - Launer,Lenore J.

AU - Breteler,Monique M. B.

AU - DeCarli,Charles

AU - Adair,Linda S.

AU - Ang,Wei

AU - Atalay,Mustafa

AU - vanBeijsterveldt,Toos

AU - Bergen,Nienke

AU - Benke,Kelly

AU - Berry,Diane

AU - Coin,Lachlan

AU - Davis,Oliver S. P.

AU - Elliott,Paul

AU - Flexeder,Claudia

AU - Frayling,Tim

AU - Gaillard,Romy

AU - Groen-Blokhuis,Maria

AU - Goh,Liang-Kee

AU - Haworth,Claire M. A.

AU - Hadley,Dexter

AU - Hedebrand,Johannes

AU - Hinney,Anke

AU - Hirschhorn,Joel N.

AU - Holloway,John W.

AU - Holst,Claus

AU - Hottenga,Jouke Jan

AU - Horikoshi,Momoko

AU - Huikari,Ville

AU - Hypponen,Elina

AU - Kilpelainen,Tuomas O.

AU - Kirin,Mirna

AU - Kowgier,Matthew

AU - Lakka,Hanna-Maaria

AU - Lange,Leslie A.

AU - Lawlor,Debbie A.

AU - Lehtimaki,Terho

AU - Lewin,Alex

AU - Lindgren,Cecilia

AU - Lindi,Virpi

AU - Maggi,Reedik

AU - Marsh,Julie

AU - Middeldorp,Christel

AU - Millwood,Iona

AU - Murray,Jeffrey C.

AU - Nivard,Michel

AU - Nohr,Ellen Aagaard

AU - Ntalla,Ioanna

AU - Oken,Emily

AU - Panoutsopoulou,Kalliope

AU - Pararajasingham,Jennifer

AU - Rodriguez,Alina

AU - Salem,Rany M.

AU - Sebert,Sylvain

AU - Siitonen,Niina

AU - Strachan,David P.

AU - Teo,Yik-Ying

AU - Valcarcel,Beatriz

AU - Willemsen,Gonneke

AU - Zeggini,Eleftheria

AU - Boomsma,Dorret I.

AU - Cooper,Cyrus

AU - Gillman,Matthew

AU - Hocher,Berthold

AU - Lakka,Timo A.

AU - Mohlke,Karen L.

AU - Dedoussis,George V.

AU - Ong,Ken K.

AU - Pearson,Ewan R.

AU - Price,Thomas S.

AU - Power,Chris

AU - Raitakari,Olli T.

AU - Saw,Seang-Mei

AU - Scherag,Andre

AU - Simell,Olli

AU - Sorensen,Thorkild I. A.

AU - Wilson,James F.

AU - Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep

PY - 2012/5

Y1 - 2012/5

N2 - During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.</p>

AB - During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.</p>

U2 - 10.1038/ng.2245

DO - 10.1038/ng.2245

M1 - Article

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

VL - 44

SP - 539

EP - 544

ER -

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