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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. / Su, Zhan; Gay, Laura J.; Strange, Amy; Palles, Claire; Band, Gavin; Whiteman, David C.; Lescai, Francesco; Langford, Cordelia; Nanji, Manoj; Edkins, Sarah; Van Der Winkel, Anouk; Levine, David; Sasieni, Peter; Bellenguez, Celine; Howarth, Kimberley; Freeman, Colin; Trudgill, Nigel; Tucker, Art T.; Pirinen, Matti; Peppelenbosch, Maikel P.; Van Der Laan, Luc J.W.; Kuipers, Ernst J.; Drenth, Joost P.H.; Peters, Wilbert H.; Reynolds, John V.; Kelleher, Dermot P.; McManus, Ross; Grabsch, Heike; Prenen, Hans; Bisschops, Raf; Krishnadath, Kausila; Siersema, Peter D.; Van Baal, Jantine W.P.M.; Middleton, Mark; Petty, Russell; Gillies, Richard; Burch, Nicola; Bhandari, Pradeep; Paterson, Stuart; Edwards, Cathryn; Penman, Ian; Vaidya, Kishor; Ang, Yeng; Murray, Iain; Patel, Praful; Ye, Weimin; Mullins, Paul; Wu, Anna H.; Bird, Nigel C.; Dallal, Helen; Shaheen, Nicholas J.; Murray, Liam J.; Koss, Konrad; Bernstein, Leslie; Romero, Yvonne; Hardie, Laura J.; Zhang, Rui; Winter, Helen; Corley, Douglas .A.; Panter, Simon; Risch, Harvey A.; Reid, Brian J.; Sargeant, Ian; Gammon, Marilie D.; Smart, Howard; Dhar, Anjan; McMurtry, Hugh; Ali, Haythem; Liu, Geoffrey; Casson, Allan G.; Chow, Wong-Ho; Rutter, Matt; Tawil, Ashref; Morris, Danielle; Nwokolo, Chuka; Isaacs, Peter; Rodgers, Colin; Ragunath, Krish; MacDonald, Chris; Haigh, Chris; Monk, David; Davies, Gareth; Wajed, Saj; Johnston, David; Gibbons, Michael; Cullen, Sue; Church, Nicholas; Langley, Ruth; Griffin, Michael; Alderson, Derek; Deloukas, Panos; Hunt, Sarah E.; Gray, Emma; Dronov, Serge; Potter, Simon C.; Tashakkori-Ghanbaria, Avazeh; Anderson, Mark; Brooks, Claire; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Mathew A.; Casas, Juan P.; Corvin, Aiden; Duncanson, Audrey; Markus, Hugh S.; Mathew, Christopher G.; Palmer, Colin N.A.; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Wood, Nicholas; Trynka, Gosia; Wijmenga, Cisca; Cazier, Jean-Baptiste; Atherfold, Paul; Nicholson, Anna M.; Gellatly, Nichola L.; Glancy, Deborah; Cooper, Sheldon C.; Cunningham, David; Lind, Tore; Hapeshi, Julie; Ferry, David; Rathbone, Barrie; Brown, Julia; Love, Sharon; Attwood, Stephen; MacGregor, Stuart; Watson, Peter; Sanders, Scott; Ek, Weronica; Harrison, Rebecca F.; Moayyedi, Paul; De Caestecker, John; Barr, Hugh; Stupka, Elia; Vaughan, Thomas L.; Peltonen, Leena; Spencer, Chris C.A.; Tomlinson, Ian; Donnelly, Peter; Jankowski, Janus A.Z.

In: Nature Genetics, Vol. 44, No. 10, 2012, p. 1131-1136.

Research output: Contribution to journalArticle

Harvard

Su, Z, Gay, LJ, Strange, A, Palles, C, Band, G, Whiteman, DC, Lescai, F, Langford, C, Nanji, M, Edkins, S, Van Der Winkel, A, Levine, D, Sasieni, P, Bellenguez, C, Howarth, K, Freeman, C, Trudgill, N, Tucker, AT, Pirinen, M, Peppelenbosch, MP, Van Der Laan, LJW, Kuipers, EJ, Drenth, JPH, Peters, WH, Reynolds, JV, Kelleher, DP, McManus, R, Grabsch, H, Prenen, H, Bisschops, R, Krishnadath, K, Siersema, PD, Van Baal, JWPM, Middleton, M, Petty, R, Gillies, R, Burch, N, Bhandari, P, Paterson, S, Edwards, C, Penman, I, Vaidya, K, Ang, Y, Murray, I, Patel, P, Ye, W, Mullins, P, Wu, AH, Bird, NC, Dallal, H, Shaheen, NJ, Murray, LJ, Koss, K, Bernstein, L, Romero, Y, Hardie, LJ, Zhang, R, Winter, H, Corley, DA, Panter, S, Risch, HA, Reid, BJ, Sargeant, I, Gammon, MD, Smart, H, Dhar, A, McMurtry, H, Ali, H, Liu, G, Casson, AG, Chow, W-H, Rutter, M, Tawil, A, Morris, D, Nwokolo, C, Isaacs, P, Rodgers, C, Ragunath, K, MacDonald, C, Haigh, C, Monk, D, Davies, G, Wajed, S, Johnston, D, Gibbons, M, Cullen, S, Church, N, Langley, R, Griffin, M, Alderson, D, Deloukas, P, Hunt, SE, Gray, E, Dronov, S, Potter, SC, Tashakkori-Ghanbaria, A, Anderson, M, Brooks, C, Blackwell, JM, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Duncanson, A, Markus, HS, Mathew, CG, Palmer, CNA, Plomin, R, Rautanen, A, Sawcer, SJ, Trembath, RC, Viswanathan, AC, Wood, N, Trynka, G, Wijmenga, C, Cazier, J-B, Atherfold, P, Nicholson, AM, Gellatly, NL, Glancy, D, Cooper, SC, Cunningham, D, Lind, T, Hapeshi, J, Ferry, D, Rathbone, B, Brown, J, Love, S, Attwood, S, MacGregor, S, Watson, P, Sanders, S, Ek, W, Harrison, RF, Moayyedi, P, De Caestecker, J, Barr, H, Stupka, E, Vaughan, TL, Peltonen, L, Spencer, CCA, Tomlinson, I, Donnelly, P & Jankowski, JAZ 2012, 'Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus' Nature Genetics, vol 44, no. 10, pp. 1131-1136.

APA

Su, Z., Gay, L. J., Strange, A., Palles, C., Band, G., Whiteman, D. C., Lescai, F., Langford, C., Nanji, M., Edkins, S., Van Der Winkel, A., Levine, D., Sasieni, P., Bellenguez, C., Howarth, K., Freeman, C., Trudgill, N., Tucker, A. T., Pirinen, M., Peppelenbosch, M. P., Van Der Laan, L. J. W., Kuipers, E. J., Drenth, J. P. H., Peters, W. H., Reynolds, J. V., Kelleher, D. P., McManus, R., Grabsch, H., Prenen, H., Bisschops, R., Krishnadath, K., Siersema, P. D., Van Baal, J. W. P. M., Middleton, M., Petty, R., Gillies, R., Burch, N., Bhandari, P., Paterson, S., Edwards, C., Penman, I., Vaidya, K., Ang, Y., Murray, I., Patel, P., Ye, W., Mullins, P., Wu, A. H., Bird, N. C., Dallal, H., Shaheen, N. J., Murray, L. J., Koss, K., Bernstein, L., Romero, Y., Hardie, L. J., Zhang, R., Winter, H., Corley, D. . A., Panter, S., Risch, H. A., Reid, B. J., Sargeant, I., Gammon, M. D., Smart, H., Dhar, A., McMurtry, H., Ali, H., Liu, G., Casson, A. G., Chow, W-H., Rutter, M., Tawil, A., Morris, D., Nwokolo, C., Isaacs, P., Rodgers, C., Ragunath, K., MacDonald, C., Haigh, C., Monk, D., Davies, G., Wajed, S., Johnston, D., Gibbons, M., Cullen, S., Church, N., Langley, R., Griffin, M., Alderson, D., Deloukas, P., Hunt, S. E., Gray, E., Dronov, S., Potter, S. C., Tashakkori-Ghanbaria, A., Anderson, M., Brooks, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N., Trynka, G., Wijmenga, C., Cazier, J-B., Atherfold, P., Nicholson, A. M., Gellatly, N. L., Glancy, D., Cooper, S. C., Cunningham, D., Lind, T., Hapeshi, J., Ferry, D., Rathbone, B., Brown, J., Love, S., Attwood, S., MacGregor, S., Watson, P., Sanders, S., Ek, W., Harrison, R. F., Moayyedi, P., De Caestecker, J., Barr, H., Stupka, E., Vaughan, T. L., Peltonen, L., Spencer, C. C. A., Tomlinson, I., Donnelly, P., & Jankowski, J. A. Z. (2012). Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nature Genetics, 44(10), 1131-1136doi: 10.1038/ng.2408

Vancouver

Su Z, Gay LJ, Strange A, Palles C, Band G, Whiteman DC et al. Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nature Genetics. 2012;44(10):1131-1136.

Author

Su, Zhan; Gay, Laura J.; Strange, Amy; Palles, Claire; Band, Gavin; Whiteman, David C.; Lescai, Francesco; Langford, Cordelia; Nanji, Manoj; Edkins, Sarah; Van Der Winkel, Anouk; Levine, David; Sasieni, Peter; Bellenguez, Celine; Howarth, Kimberley; Freeman, Colin; Trudgill, Nigel; Tucker, Art T.; Pirinen, Matti; Peppelenbosch, Maikel P.; Van Der Laan, Luc J.W.; Kuipers, Ernst J.; Drenth, Joost P.H.; Peters, Wilbert H.; Reynolds, John V.; Kelleher, Dermot P.; McManus, Ross; Grabsch, Heike; Prenen, Hans; Bisschops, Raf; Krishnadath, Kausila; Siersema, Peter D.; Van Baal, Jantine W.P.M.; Middleton, Mark; Petty, Russell; Gillies, Richard; Burch, Nicola; Bhandari, Pradeep; Paterson, Stuart; Edwards, Cathryn; Penman, Ian; Vaidya, Kishor; Ang, Yeng; Murray, Iain; Patel, Praful; Ye, Weimin; Mullins, Paul; Wu, Anna H.; Bird, Nigel C.; Dallal, Helen; Shaheen, Nicholas J.; Murray, Liam J.; Koss, Konrad; Bernstein, Leslie; Romero, Yvonne; Hardie, Laura J.; Zhang, Rui; Winter, Helen; Corley, Douglas .A.; Panter, Simon; Risch, Harvey A.; Reid, Brian J.; Sargeant, Ian; Gammon, Marilie D.; Smart, Howard; Dhar, Anjan; McMurtry, Hugh; Ali, Haythem; Liu, Geoffrey; Casson, Allan G.; Chow, Wong-Ho; Rutter, Matt; Tawil, Ashref; Morris, Danielle; Nwokolo, Chuka; Isaacs, Peter; Rodgers, Colin; Ragunath, Krish; MacDonald, Chris; Haigh, Chris; Monk, David; Davies, Gareth; Wajed, Saj; Johnston, David; Gibbons, Michael; Cullen, Sue; Church, Nicholas; Langley, Ruth; Griffin, Michael; Alderson, Derek; Deloukas, Panos; Hunt, Sarah E.; Gray, Emma; Dronov, Serge; Potter, Simon C.; Tashakkori-Ghanbaria, Avazeh; Anderson, Mark; Brooks, Claire; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Mathew A.; Casas, Juan P.; Corvin, Aiden; Duncanson, Audrey; Markus, Hugh S.; Mathew, Christopher G.; Palmer, Colin N.A.; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Wood, Nicholas; Trynka, Gosia; Wijmenga, Cisca; Cazier, Jean-Baptiste; Atherfold, Paul; Nicholson, Anna M.; Gellatly, Nichola L.; Glancy, Deborah; Cooper, Sheldon C.; Cunningham, David; Lind, Tore; Hapeshi, Julie; Ferry, David; Rathbone, Barrie; Brown, Julia; Love, Sharon; Attwood, Stephen; MacGregor, Stuart; Watson, Peter; Sanders, Scott; Ek, Weronica; Harrison, Rebecca F.; Moayyedi, Paul; De Caestecker, John; Barr, Hugh; Stupka, Elia; Vaughan, Thomas L.; Peltonen, Leena; Spencer, Chris C.A.; Tomlinson, Ian; Donnelly, Peter; Jankowski, Janus A.Z. / Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.

In: Nature Genetics, Vol. 44, No. 10, 2012, p. 1131-1136.

Research output: Contribution to journalArticle

Bibtex - Download

@article{cefa9a5a6b3d4c82a5d45d1f090abb34,
title = "Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus",
author = "Zhan Su and Gay, {Laura J.} and Amy Strange and Claire Palles and Gavin Band and Whiteman, {David C.} and Francesco Lescai and Cordelia Langford and Manoj Nanji and Sarah Edkins and {Van Der Winkel}, Anouk and David Levine and Peter Sasieni and Celine Bellenguez and Kimberley Howarth and Colin Freeman and Nigel Trudgill and Tucker, {Art T.} and Matti Pirinen and Peppelenbosch, {Maikel P.} and {Van Der Laan}, {Luc J.W.} and Kuipers, {Ernst J.} and Drenth, {Joost P.H.} and Peters, {Wilbert H.} and Reynolds, {John V.} and Kelleher, {Dermot P.} and Ross McManus and Heike Grabsch and Hans Prenen and Raf Bisschops and Kausila Krishnadath and Siersema, {Peter D.} and {Van Baal}, {Jantine W.P.M.} and Mark Middleton and Russell Petty and Richard Gillies and Nicola Burch and Pradeep Bhandari and Stuart Paterson and Cathryn Edwards and Ian Penman and Kishor Vaidya and Yeng Ang and Iain Murray and Praful Patel and Weimin Ye and Paul Mullins and Wu, {Anna H.} and Bird, {Nigel C.} and Helen Dallal and Shaheen, {Nicholas J.} and Murray, {Liam J.} and Konrad Koss and Leslie Bernstein and Yvonne Romero and Hardie, {Laura J.} and Rui Zhang and Helen Winter and Corley, {Douglas .A.} and Simon Panter and Risch, {Harvey A.} and Reid, {Brian J.} and Ian Sargeant and Gammon, {Marilie D.} and Howard Smart and Anjan Dhar and Hugh McMurtry and Haythem Ali and Geoffrey Liu and Casson, {Allan G.} and Wong-Ho Chow and Matt Rutter and Ashref Tawil and Danielle Morris and Chuka Nwokolo and Peter Isaacs and Colin Rodgers and Krish Ragunath and Chris MacDonald and Chris Haigh and David Monk and Gareth Davies and Saj Wajed and David Johnston and Michael Gibbons and Sue Cullen and Nicholas Church and Ruth Langley and Michael Griffin and Derek Alderson and Panos Deloukas and Hunt, {Sarah E.} and Emma Gray and Serge Dronov and Potter, {Simon C.} and Avazeh Tashakkori-Ghanbaria and Mark Anderson and Claire Brooks and Blackwell, {Jenefer M.} and Elvira Bramon and Brown, {Mathew A.} and Casas, {Juan P.} and Aiden Corvin and Audrey Duncanson and Markus, {Hugh S.} and Mathew, {Christopher G.} and Palmer, {Colin N.A.} and Robert Plomin and Anna Rautanen and Sawcer, {Stephen J.} and Trembath, {Richard C.} and Viswanathan, {Ananth C.} and Nicholas Wood and Gosia Trynka and Cisca Wijmenga and Jean-Baptiste Cazier and Paul Atherfold and Nicholson, {Anna M.} and Gellatly, {Nichola L.} and Deborah Glancy and Cooper, {Sheldon C.} and David Cunningham and Tore Lind and Julie Hapeshi and David Ferry and Barrie Rathbone and Julia Brown and Sharon Love and Stephen Attwood and Stuart MacGregor and Peter Watson and Scott Sanders and Weronica Ek and Harrison, {Rebecca F.} and Paul Moayyedi and {De Caestecker}, John and Hugh Barr and Elia Stupka and Vaughan, {Thomas L.} and Leena Peltonen and Spencer, {Chris C.A.} and Ian Tomlinson and Peter Donnelly and Jankowski, {Janus A.Z.}",
year = "2012",
volume = "44",
number = "10",
pages = "1131--1136",
journal = "Nature Genetics",
issn = "1061-4036",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

A1 - Su,Zhan

A1 - Gay,Laura J.

A1 - Strange,Amy

A1 - Palles,Claire

A1 - Band,Gavin

A1 - Whiteman,David C.

A1 - Lescai,Francesco

A1 - Langford,Cordelia

A1 - Nanji,Manoj

A1 - Edkins,Sarah

A1 - Van Der Winkel,Anouk

A1 - Levine,David

A1 - Sasieni,Peter

A1 - Bellenguez,Celine

A1 - Howarth,Kimberley

A1 - Freeman,Colin

A1 - Trudgill,Nigel

A1 - Tucker,Art T.

A1 - Pirinen,Matti

A1 - Peppelenbosch,Maikel P.

A1 - Van Der Laan,Luc J.W.

A1 - Kuipers,Ernst J.

A1 - Drenth,Joost P.H.

A1 - Peters,Wilbert H.

A1 - Reynolds,John V.

A1 - Kelleher,Dermot P.

A1 - McManus,Ross

A1 - Grabsch,Heike

A1 - Prenen,Hans

A1 - Bisschops,Raf

A1 - Krishnadath,Kausila

A1 - Siersema,Peter D.

A1 - Van Baal,Jantine W.P.M.

A1 - Middleton,Mark

A1 - Petty,Russell

A1 - Gillies,Richard

A1 - Burch,Nicola

A1 - Bhandari,Pradeep

A1 - Paterson,Stuart

A1 - Edwards,Cathryn

A1 - Penman,Ian

A1 - Vaidya,Kishor

A1 - Ang,Yeng

A1 - Murray,Iain

A1 - Patel,Praful

A1 - Ye,Weimin

A1 - Mullins,Paul

A1 - Wu,Anna H.

A1 - Bird,Nigel C.

A1 - Dallal,Helen

A1 - Shaheen,Nicholas J.

A1 - Murray,Liam J.

A1 - Koss,Konrad

A1 - Bernstein,Leslie

A1 - Romero,Yvonne

A1 - Hardie,Laura J.

A1 - Zhang,Rui

A1 - Winter,Helen

A1 - Corley,Douglas .A.

A1 - Panter,Simon

A1 - Risch,Harvey A.

A1 - Reid,Brian J.

A1 - Sargeant,Ian

A1 - Gammon,Marilie D.

A1 - Smart,Howard

A1 - Dhar,Anjan

A1 - McMurtry,Hugh

A1 - Ali,Haythem

A1 - Liu,Geoffrey

A1 - Casson,Allan G.

A1 - Chow,Wong-Ho

A1 - Rutter,Matt

A1 - Tawil,Ashref

A1 - Morris,Danielle

A1 - Nwokolo,Chuka

A1 - Isaacs,Peter

A1 - Rodgers,Colin

A1 - Ragunath,Krish

A1 - MacDonald,Chris

A1 - Haigh,Chris

A1 - Monk,David

A1 - Davies,Gareth

A1 - Wajed,Saj

A1 - Johnston,David

A1 - Gibbons,Michael

A1 - Cullen,Sue

A1 - Church,Nicholas

A1 - Langley,Ruth

A1 - Griffin,Michael

A1 - Alderson,Derek

A1 - Deloukas,Panos

A1 - Hunt,Sarah E.

A1 - Gray,Emma

A1 - Dronov,Serge

A1 - Potter,Simon C.

A1 - Tashakkori-Ghanbaria,Avazeh

A1 - Anderson,Mark

A1 - Brooks,Claire

A1 - Blackwell,Jenefer M.

A1 - Bramon,Elvira

A1 - Brown,Mathew A.

A1 - Casas,Juan P.

A1 - Corvin,Aiden

A1 - Duncanson,Audrey

A1 - Markus,Hugh S.

A1 - Mathew,Christopher G.

A1 - Palmer,Colin N.A.

A1 - Plomin,Robert

A1 - Rautanen,Anna

A1 - Sawcer,Stephen J.

A1 - Trembath,Richard C.

A1 - Viswanathan,Ananth C.

A1 - Wood,Nicholas

A1 - Trynka,Gosia

A1 - Wijmenga,Cisca

A1 - Cazier,Jean-Baptiste

A1 - Atherfold,Paul

A1 - Nicholson,Anna M.

A1 - Gellatly,Nichola L.

A1 - Glancy,Deborah

A1 - Cooper,Sheldon C.

A1 - Cunningham,David

A1 - Lind,Tore

A1 - Hapeshi,Julie

A1 - Ferry,David

A1 - Rathbone,Barrie

A1 - Brown,Julia

A1 - Love,Sharon

A1 - Attwood,Stephen

A1 - MacGregor,Stuart

A1 - Watson,Peter

A1 - Sanders,Scott

A1 - Ek,Weronica

A1 - Harrison,Rebecca F.

A1 - Moayyedi,Paul

A1 - De Caestecker,John

A1 - Barr,Hugh

A1 - Stupka,Elia

A1 - Vaughan,Thomas L.

A1 - Peltonen,Leena

A1 - Spencer,Chris C.A.

A1 - Tomlinson,Ian

A1 - Donnelly,Peter

A1 - Jankowski,Janus A.Z.

AU - Su,Zhan

AU - Gay,Laura J.

AU - Strange,Amy

AU - Palles,Claire

AU - Band,Gavin

AU - Whiteman,David C.

AU - Lescai,Francesco

AU - Langford,Cordelia

AU - Nanji,Manoj

AU - Edkins,Sarah

AU - Van Der Winkel,Anouk

AU - Levine,David

AU - Sasieni,Peter

AU - Bellenguez,Celine

AU - Howarth,Kimberley

AU - Freeman,Colin

AU - Trudgill,Nigel

AU - Tucker,Art T.

AU - Pirinen,Matti

AU - Peppelenbosch,Maikel P.

AU - Van Der Laan,Luc J.W.

AU - Kuipers,Ernst J.

AU - Drenth,Joost P.H.

AU - Peters,Wilbert H.

AU - Reynolds,John V.

AU - Kelleher,Dermot P.

AU - McManus,Ross

AU - Grabsch,Heike

AU - Prenen,Hans

AU - Bisschops,Raf

AU - Krishnadath,Kausila

AU - Siersema,Peter D.

AU - Van Baal,Jantine W.P.M.

AU - Middleton,Mark

AU - Petty,Russell

AU - Gillies,Richard

AU - Burch,Nicola

AU - Bhandari,Pradeep

AU - Paterson,Stuart

AU - Edwards,Cathryn

AU - Penman,Ian

AU - Vaidya,Kishor

AU - Ang,Yeng

AU - Murray,Iain

AU - Patel,Praful

AU - Ye,Weimin

AU - Mullins,Paul

AU - Wu,Anna H.

AU - Bird,Nigel C.

AU - Dallal,Helen

AU - Shaheen,Nicholas J.

AU - Murray,Liam J.

AU - Koss,Konrad

AU - Bernstein,Leslie

AU - Romero,Yvonne

AU - Hardie,Laura J.

AU - Zhang,Rui

AU - Winter,Helen

AU - Corley,Douglas .A.

AU - Panter,Simon

AU - Risch,Harvey A.

AU - Reid,Brian J.

AU - Sargeant,Ian

AU - Gammon,Marilie D.

AU - Smart,Howard

AU - Dhar,Anjan

AU - McMurtry,Hugh

AU - Ali,Haythem

AU - Liu,Geoffrey

AU - Casson,Allan G.

AU - Chow,Wong-Ho

AU - Rutter,Matt

AU - Tawil,Ashref

AU - Morris,Danielle

AU - Nwokolo,Chuka

AU - Isaacs,Peter

AU - Rodgers,Colin

AU - Ragunath,Krish

AU - MacDonald,Chris

AU - Haigh,Chris

AU - Monk,David

AU - Davies,Gareth

AU - Wajed,Saj

AU - Johnston,David

AU - Gibbons,Michael

AU - Cullen,Sue

AU - Church,Nicholas

AU - Langley,Ruth

AU - Griffin,Michael

AU - Alderson,Derek

AU - Deloukas,Panos

AU - Hunt,Sarah E.

AU - Gray,Emma

AU - Dronov,Serge

AU - Potter,Simon C.

AU - Tashakkori-Ghanbaria,Avazeh

AU - Anderson,Mark

AU - Brooks,Claire

AU - Blackwell,Jenefer M.

AU - Bramon,Elvira

AU - Brown,Mathew A.

AU - Casas,Juan P.

AU - Corvin,Aiden

AU - Duncanson,Audrey

AU - Markus,Hugh S.

AU - Mathew,Christopher G.

AU - Palmer,Colin N.A.

AU - Plomin,Robert

AU - Rautanen,Anna

AU - Sawcer,Stephen J.

AU - Trembath,Richard C.

AU - Viswanathan,Ananth C.

AU - Wood,Nicholas

AU - Trynka,Gosia

AU - Wijmenga,Cisca

AU - Cazier,Jean-Baptiste

AU - Atherfold,Paul

AU - Nicholson,Anna M.

AU - Gellatly,Nichola L.

AU - Glancy,Deborah

AU - Cooper,Sheldon C.

AU - Cunningham,David

AU - Lind,Tore

AU - Hapeshi,Julie

AU - Ferry,David

AU - Rathbone,Barrie

AU - Brown,Julia

AU - Love,Sharon

AU - Attwood,Stephen

AU - MacGregor,Stuart

AU - Watson,Peter

AU - Sanders,Scott

AU - Ek,Weronica

AU - Harrison,Rebecca F.

AU - Moayyedi,Paul

AU - De Caestecker,John

AU - Barr,Hugh

AU - Stupka,Elia

AU - Vaughan,Thomas L.

AU - Peltonen,Leena

AU - Spencer,Chris C.A.

AU - Tomlinson,Ian

AU - Donnelly,Peter

AU - Jankowski,Janus A.Z.

PY - 2012

Y1 - 2012

N2 - Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (P combined = 4.09 × 10 ; odds ratio (OR) = 1.21, 95% confidence interval (CI) =1.13-1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (P combined = 2.74 × 10 ; OR = 1.14, 95% CI = 1.10-1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus. © 2012 Nature America, Inc. All rights reserved.

AB - Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (P combined = 4.09 × 10 ; odds ratio (OR) = 1.21, 95% confidence interval (CI) =1.13-1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (P combined = 2.74 × 10 ; OR = 1.14, 95% CI = 1.10-1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus. © 2012 Nature America, Inc. All rights reserved.

U2 - 10.1038/ng.2408

DO - 10.1038/ng.2408

M1 - Article

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

VL - 44

SP - 1131

EP - 1136

ER -

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