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Consensus statements for management of Barrett's Dysplasia and early-stage Esophageal Adenocarcinoma, based on a Delphi Process

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Consensus statements for management of Barrett's Dysplasia and early-stage Esophageal Adenocarcinoma, based on a Delphi Process. / Bennett, Cathy; Vakil, Nimish; Bergman, Jacques; Harrison, Rebecca; Odze, Robert; Vieth, Michael; Sanders, Scott; Gay, Laura; Pech, Oliver; Longcroft-Wheaton, Gaius; Romero, Yvonne; Inadomi, John; Tack, Jan; Corley, Douglas A.; Manner, Hendrik; Green, Susi; Al Dulaimi, David; Ali, Haythem; Allum, Bill; Anderson, Mark; Curtis, Howard; Falk, Gary; Fennerty, M. Brian; Fullarton, Grant; Krishnadath, Kausilia; Meltzer, Stephen J.; Armstrong, David; Ganz, Robert; Cengia, Gianpaolo; Going, James J.; Goldblum, John; Gordon, Charles; Grabsch, Heike; Haigh, Chris; Hongo, Michio; Johnston, David; Forbes-Young, Ricky; Kay, Elaine; Kaye, Philip; Lerut, Toni; Lovat, Laurence B.; Lundell, Lars; Mairs, Philip; Shimoda, Tadakuza; Spechler, Stuart; Sontag, Stephen; Malfertheiner, Peter; Murray, Iain; Nanji, Manoj; Poller, David; Ragunath, Krish; Regula, Jaroslaw; Cestari, Renzo; Shepherd, Neil; Singh, Rajvinder; Stein, Hubert J.; Talley, Nicholas J.; Galmiche, Jean-Paul; Tham, Tony C. K.; Watson, Peter; Yerian, Lisa; Rugge, Massimo; Rice, Thomas W.; Hart, John; Gittens, Stuart; Hewin, David; Hochberger, Juergen; Kahrilas, Peter; Preston, Sean; Sampliner, Richard; Sharma, Prateek; Stuart, Robert; Wang, Kenneth; Waxman, Irving; Abley, Chris; Loft, Duncan; Penman, Ian; Shaheen, Nicholas J.; Chak, Amitabh; Davies, Gareth; Dunn, Lorna; Falck-Ytter, Yngve; Decaestecker, John; Bhandari, Pradeep; Ell, Christian; Griffin, Michael; Attwood, Stephen; Barr, Hugh; Allen, John; Ferguson, Mark K.; Moayyedi, Paul; Jankowski, Janusz A. Z.

In: Gastroenterology, Vol. 143, No. 2, 08.2012, p. 336-346.

Research output: Contribution to journalArticle

Harvard

Bennett, C, Vakil, N, Bergman, J, Harrison, R, Odze, R, Vieth, M, Sanders, S, Gay, L, Pech, O, Longcroft-Wheaton, G, Romero, Y, Inadomi, J, Tack, J, Corley, DA, Manner, H, Green, S, Al Dulaimi, D, Ali, H, Allum, B, Anderson, M, Curtis, H, Falk, G, Fennerty, MB, Fullarton, G, Krishnadath, K, Meltzer, SJ, Armstrong, D, Ganz, R, Cengia, G, Going, JJ, Goldblum, J, Gordon, C, Grabsch, H, Haigh, C, Hongo, M, Johnston, D, Forbes-Young, R, Kay, E, Kaye, P, Lerut, T, Lovat, LB, Lundell, L, Mairs, P, Shimoda, T, Spechler, S, Sontag, S, Malfertheiner, P, Murray, I, Nanji, M, Poller, D, Ragunath, K, Regula, J, Cestari, R, Shepherd, N, Singh, R, Stein, HJ, Talley, NJ, Galmiche, J-P, Tham, TCK, Watson, P, Yerian, L, Rugge, M, Rice, TW, Hart, J, Gittens, S, Hewin, D, Hochberger, J, Kahrilas, P, Preston, S, Sampliner, R, Sharma, P, Stuart, R, Wang, K, Waxman, I, Abley, C, Loft, D, Penman, I, Shaheen, NJ, Chak, A, Davies, G, Dunn, L, Falck-Ytter, Y, Decaestecker, J, Bhandari, P, Ell, C, Griffin, M, Attwood, S, Barr, H, Allen, J, Ferguson, MK, Moayyedi, P & Jankowski, JAZ 2012, 'Consensus statements for management of Barrett's Dysplasia and early-stage Esophageal Adenocarcinoma, based on a Delphi Process' Gastroenterology, vol 143, no. 2, pp. 336-346., 10.1053/j.gastro.2012.04.032

APA

Bennett, C., Vakil, N., Bergman, J., Harrison, R., Odze, R., Vieth, M., ... Jankowski, J. A. Z. (2012). Consensus statements for management of Barrett's Dysplasia and early-stage Esophageal Adenocarcinoma, based on a Delphi Process. Gastroenterology, 143(2), 336-346. 10.1053/j.gastro.2012.04.032

Vancouver

Bennett C, Vakil N, Bergman J, Harrison R, Odze R, Vieth M et al. Consensus statements for management of Barrett's Dysplasia and early-stage Esophageal Adenocarcinoma, based on a Delphi Process. Gastroenterology. 2012 Aug;143(2):336-346. Available from: 10.1053/j.gastro.2012.04.032

Author

Bennett, Cathy; Vakil, Nimish; Bergman, Jacques; Harrison, Rebecca; Odze, Robert; Vieth, Michael; Sanders, Scott; Gay, Laura; Pech, Oliver; Longcroft-Wheaton, Gaius; Romero, Yvonne; Inadomi, John; Tack, Jan; Corley, Douglas A.; Manner, Hendrik; Green, Susi; Al Dulaimi, David; Ali, Haythem; Allum, Bill; Anderson, Mark; Curtis, Howard; Falk, Gary; Fennerty, M. Brian; Fullarton, Grant; Krishnadath, Kausilia; Meltzer, Stephen J.; Armstrong, David; Ganz, Robert; Cengia, Gianpaolo; Going, James J.; Goldblum, John; Gordon, Charles; Grabsch, Heike; Haigh, Chris; Hongo, Michio; Johnston, David; Forbes-Young, Ricky; Kay, Elaine; Kaye, Philip; Lerut, Toni; Lovat, Laurence B.; Lundell, Lars; Mairs, Philip; Shimoda, Tadakuza; Spechler, Stuart; Sontag, Stephen; Malfertheiner, Peter; Murray, Iain; Nanji, Manoj; Poller, David; Ragunath, Krish; Regula, Jaroslaw; Cestari, Renzo; Shepherd, Neil; Singh, Rajvinder; Stein, Hubert J.; Talley, Nicholas J.; Galmiche, Jean-Paul; Tham, Tony C. K.; Watson, Peter; Yerian, Lisa; Rugge, Massimo; Rice, Thomas W.; Hart, John; Gittens, Stuart; Hewin, David; Hochberger, Juergen; Kahrilas, Peter; Preston, Sean; Sampliner, Richard; Sharma, Prateek; Stuart, Robert; Wang, Kenneth; Waxman, Irving; Abley, Chris; Loft, Duncan; Penman, Ian; Shaheen, Nicholas J.; Chak, Amitabh; Davies, Gareth; Dunn, Lorna; Falck-Ytter, Yngve; Decaestecker, John; Bhandari, Pradeep; Ell, Christian; Griffin, Michael; Attwood, Stephen; Barr, Hugh; Allen, John; Ferguson, Mark K.; Moayyedi, Paul; Jankowski, Janusz A. Z. / Consensus statements for management of Barrett's Dysplasia and early-stage Esophageal Adenocarcinoma, based on a Delphi Process.

In: Gastroenterology, Vol. 143, No. 2, 08.2012, p. 336-346.

Research output: Contribution to journalArticle

Bibtex - Download

@article{6ef919321db1432484159bce6982b03b,
title = "Consensus statements for management of Barrett's Dysplasia and early-stage Esophageal Adenocarcinoma, based on a Delphi Process",
author = "Cathy Bennett and Nimish Vakil and Jacques Bergman and Rebecca Harrison and Robert Odze and Michael Vieth and Scott Sanders and Laura Gay and Oliver Pech and Gaius Longcroft-Wheaton and Yvonne Romero and John Inadomi and Jan Tack and Corley, {Douglas A.} and Hendrik Manner and Susi Green and {Al Dulaimi}, David and Haythem Ali and Bill Allum and Mark Anderson and Howard Curtis and Gary Falk and Fennerty, {M. Brian} and Grant Fullarton and Kausilia Krishnadath and Meltzer, {Stephen J.} and David Armstrong and Robert Ganz and Gianpaolo Cengia and Going, {James J.} and John Goldblum and Charles Gordon and Heike Grabsch and Chris Haigh and Michio Hongo and David Johnston and Ricky Forbes-Young and Elaine Kay and Philip Kaye and Toni Lerut and Lovat, {Laurence B.} and Lars Lundell and Philip Mairs and Tadakuza Shimoda and Stuart Spechler and Stephen Sontag and Peter Malfertheiner and Iain Murray and Manoj Nanji and David Poller and Krish Ragunath and Jaroslaw Regula and Renzo Cestari and Neil Shepherd and Rajvinder Singh and Stein, {Hubert J.} and Talley, {Nicholas J.} and Jean-Paul Galmiche and Tham, {Tony C. K.} and Peter Watson and Lisa Yerian and Massimo Rugge and Rice, {Thomas W.} and John Hart and Stuart Gittens and David Hewin and Juergen Hochberger and Peter Kahrilas and Sean Preston and Richard Sampliner and Prateek Sharma and Robert Stuart and Kenneth Wang and Irving Waxman and Chris Abley and Duncan Loft and Ian Penman and Shaheen, {Nicholas J.} and Amitabh Chak and Gareth Davies and Lorna Dunn and Yngve Falck-Ytter and John Decaestecker and Pradeep Bhandari and Christian Ell and Michael Griffin and Stephen Attwood and Hugh Barr and John Allen and Ferguson, {Mark K.} and Paul Moayyedi and Jankowski, {Janusz A. Z.}",
year = "2012",
doi = "10.1053/j.gastro.2012.04.032",
volume = "143",
number = "2",
pages = "336--346",
journal = "Gastroenterology",
issn = "0016-5085",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Consensus statements for management of Barrett's Dysplasia and early-stage Esophageal Adenocarcinoma, based on a Delphi Process

A1 - Bennett,Cathy

A1 - Vakil,Nimish

A1 - Bergman,Jacques

A1 - Harrison,Rebecca

A1 - Odze,Robert

A1 - Vieth,Michael

A1 - Sanders,Scott

A1 - Gay,Laura

A1 - Pech,Oliver

A1 - Longcroft-Wheaton,Gaius

A1 - Romero,Yvonne

A1 - Inadomi,John

A1 - Tack,Jan

A1 - Corley,Douglas A.

A1 - Manner,Hendrik

A1 - Green,Susi

A1 - Al Dulaimi,David

A1 - Ali,Haythem

A1 - Allum,Bill

A1 - Anderson,Mark

A1 - Curtis,Howard

A1 - Falk,Gary

A1 - Fennerty,M. Brian

A1 - Fullarton,Grant

A1 - Krishnadath,Kausilia

A1 - Meltzer,Stephen J.

A1 - Armstrong,David

A1 - Ganz,Robert

A1 - Cengia,Gianpaolo

A1 - Going,James J.

A1 - Goldblum,John

A1 - Gordon,Charles

A1 - Grabsch,Heike

A1 - Haigh,Chris

A1 - Hongo,Michio

A1 - Johnston,David

A1 - Forbes-Young,Ricky

A1 - Kay,Elaine

A1 - Kaye,Philip

A1 - Lerut,Toni

A1 - Lovat,Laurence B.

A1 - Lundell,Lars

A1 - Mairs,Philip

A1 - Shimoda,Tadakuza

A1 - Spechler,Stuart

A1 - Sontag,Stephen

A1 - Malfertheiner,Peter

A1 - Murray,Iain

A1 - Nanji,Manoj

A1 - Poller,David

A1 - Ragunath,Krish

A1 - Regula,Jaroslaw

A1 - Cestari,Renzo

A1 - Shepherd,Neil

A1 - Singh,Rajvinder

A1 - Stein,Hubert J.

A1 - Talley,Nicholas J.

A1 - Galmiche,Jean-Paul

A1 - Tham,Tony C. K.

A1 - Watson,Peter

A1 - Yerian,Lisa

A1 - Rugge,Massimo

A1 - Rice,Thomas W.

A1 - Hart,John

A1 - Gittens,Stuart

A1 - Hewin,David

A1 - Hochberger,Juergen

A1 - Kahrilas,Peter

A1 - Preston,Sean

A1 - Sampliner,Richard

A1 - Sharma,Prateek

A1 - Stuart,Robert

A1 - Wang,Kenneth

A1 - Waxman,Irving

A1 - Abley,Chris

A1 - Loft,Duncan

A1 - Penman,Ian

A1 - Shaheen,Nicholas J.

A1 - Chak,Amitabh

A1 - Davies,Gareth

A1 - Dunn,Lorna

A1 - Falck-Ytter,Yngve

A1 - Decaestecker,John

A1 - Bhandari,Pradeep

A1 - Ell,Christian

A1 - Griffin,Michael

A1 - Attwood,Stephen

A1 - Barr,Hugh

A1 - Allen,John

A1 - Ferguson,Mark K.

A1 - Moayyedi,Paul

A1 - Jankowski,Janusz A. Z.

AU - Bennett,Cathy

AU - Vakil,Nimish

AU - Bergman,Jacques

AU - Harrison,Rebecca

AU - Odze,Robert

AU - Vieth,Michael

AU - Sanders,Scott

AU - Gay,Laura

AU - Pech,Oliver

AU - Longcroft-Wheaton,Gaius

AU - Romero,Yvonne

AU - Inadomi,John

AU - Tack,Jan

AU - Corley,Douglas A.

AU - Manner,Hendrik

AU - Green,Susi

AU - Al Dulaimi,David

AU - Ali,Haythem

AU - Allum,Bill

AU - Anderson,Mark

AU - Curtis,Howard

AU - Falk,Gary

AU - Fennerty,M. Brian

AU - Fullarton,Grant

AU - Krishnadath,Kausilia

AU - Meltzer,Stephen J.

AU - Armstrong,David

AU - Ganz,Robert

AU - Cengia,Gianpaolo

AU - Going,James J.

AU - Goldblum,John

AU - Gordon,Charles

AU - Grabsch,Heike

AU - Haigh,Chris

AU - Hongo,Michio

AU - Johnston,David

AU - Forbes-Young,Ricky

AU - Kay,Elaine

AU - Kaye,Philip

AU - Lerut,Toni

AU - Lovat,Laurence B.

AU - Lundell,Lars

AU - Mairs,Philip

AU - Shimoda,Tadakuza

AU - Spechler,Stuart

AU - Sontag,Stephen

AU - Malfertheiner,Peter

AU - Murray,Iain

AU - Nanji,Manoj

AU - Poller,David

AU - Ragunath,Krish

AU - Regula,Jaroslaw

AU - Cestari,Renzo

AU - Shepherd,Neil

AU - Singh,Rajvinder

AU - Stein,Hubert J.

AU - Talley,Nicholas J.

AU - Galmiche,Jean-Paul

AU - Tham,Tony C. K.

AU - Watson,Peter

AU - Yerian,Lisa

AU - Rugge,Massimo

AU - Rice,Thomas W.

AU - Hart,John

AU - Gittens,Stuart

AU - Hewin,David

AU - Hochberger,Juergen

AU - Kahrilas,Peter

AU - Preston,Sean

AU - Sampliner,Richard

AU - Sharma,Prateek

AU - Stuart,Robert

AU - Wang,Kenneth

AU - Waxman,Irving

AU - Abley,Chris

AU - Loft,Duncan

AU - Penman,Ian

AU - Shaheen,Nicholas J.

AU - Chak,Amitabh

AU - Davies,Gareth

AU - Dunn,Lorna

AU - Falck-Ytter,Yngve

AU - Decaestecker,John

AU - Bhandari,Pradeep

AU - Ell,Christian

AU - Griffin,Michael

AU - Attwood,Stephen

AU - Barr,Hugh

AU - Allen,John

AU - Ferguson,Mark K.

AU - Moayyedi,Paul

AU - Jankowski,Janusz A. Z.

PY - 2012/8

Y1 - 2012/8

N2 - <p>BACKGROUND &amp; AIMS: Esophageal adenocarcinoma (EA) is increasingly common among patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations based on the medical literature that clinicians could use to manage patients with BE and low-grade dysplasia, high-grade dysplasia (HGD), or early-stage EA. METHODS: We performed an international, multidisciplinary, systematic, evidence-based review of different management strategies for patients with BE and dysplasia or early-stage EA. We used a Delphi process to develop consensus statements. The results of literature searches were screened using a unique, interactive, Web-based data-sifting platform; we used 11,904 papers to inform the choice of statements selected. An a priori threshold of 80% agreement was used to establish consensus for each statement. RESULTS: Eighty-one of the 91 statements achieved consensus despite generally low quality of evidence, including 8 clinical statements: (1) specimens from endoscopic resection are better than biopsies for staging lesions, (2) it is important to carefully map the size of the dysplastic areas, (3) patients that receive ablative or surgical therapy require endoscopic follow-up, (4) high-resolution endoscopy is necessary for accurate diagnosis, (5) endoscopic therapy for HGD is preferred to surveillance, (6) endoscopic therapy for HGD is preferred to surgery, (7) the combination of endoscopic resection and radiofrequency ablation is the most effective therapy, and (8) after endoscopic removal of lesions from patients with HGD, all areas of BE should be ablated. CONCLUSIONS: We developed a data-sifting platform and used the Delphi process to create evidence-based consensus statements for the management of patients with BE and early-stage EA. This approach identified important clinical features of the diseases and areas for future studies.</p>

AB - <p>BACKGROUND &amp; AIMS: Esophageal adenocarcinoma (EA) is increasingly common among patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations based on the medical literature that clinicians could use to manage patients with BE and low-grade dysplasia, high-grade dysplasia (HGD), or early-stage EA. METHODS: We performed an international, multidisciplinary, systematic, evidence-based review of different management strategies for patients with BE and dysplasia or early-stage EA. We used a Delphi process to develop consensus statements. The results of literature searches were screened using a unique, interactive, Web-based data-sifting platform; we used 11,904 papers to inform the choice of statements selected. An a priori threshold of 80% agreement was used to establish consensus for each statement. RESULTS: Eighty-one of the 91 statements achieved consensus despite generally low quality of evidence, including 8 clinical statements: (1) specimens from endoscopic resection are better than biopsies for staging lesions, (2) it is important to carefully map the size of the dysplastic areas, (3) patients that receive ablative or surgical therapy require endoscopic follow-up, (4) high-resolution endoscopy is necessary for accurate diagnosis, (5) endoscopic therapy for HGD is preferred to surveillance, (6) endoscopic therapy for HGD is preferred to surgery, (7) the combination of endoscopic resection and radiofrequency ablation is the most effective therapy, and (8) after endoscopic removal of lesions from patients with HGD, all areas of BE should be ablated. CONCLUSIONS: We developed a data-sifting platform and used the Delphi process to create evidence-based consensus statements for the management of patients with BE and early-stage EA. This approach identified important clinical features of the diseases and areas for future studies.</p>

U2 - 10.1053/j.gastro.2012.04.032

DO - 10.1053/j.gastro.2012.04.032

M1 - Article

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 2

VL - 143

SP - 336

EP - 346

ER -

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