Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia. / Ånensen, N.; Hjelle, S. M.; Van Belle, W.; Haaland, I.; Silden, E.; Bourdon, J.-C.; Hovland, R.; Taskén, K.; Knappskog, S.; Lønning, P.E.; Bruserud, O.; Gjertsen, B. T.
In: Oncogene, Vol. 31, No. 12, 22.03.2012, p. 1533-1545.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia
A1 - Ånensen,N.
A1 - Hjelle,S. M.
A1 - Van Belle,W.
A1 - Haaland,I.
A1 - Silden,E.
A1 - Bourdon,J.-C.
A1 - Hovland,R.
A1 - Taskén,K.
A1 - Knappskog,S.
A1 - Lønning,P.E.
A1 - Bruserud,O.
A1 - Gjertsen,B. T.
AU - Ånensen,N.
AU - Hjelle,S. M.
AU - Van Belle,W.
AU - Haaland,I.
AU - Silden,E.
AU - Bourdon,J.-C.
AU - Hovland,R.
AU - Taskén,K.
AU - Knappskog,S.
AU - Lønning,P.E.
AU - Bruserud,O.
AU - Gjertsen,B. T.
PY - 2012/3/22
Y1 - 2012/3/22
N2 - The wild-type tumor-suppressor gene TP53 encodes several isoforms of the p53 protein. However, while the role of p53 in controlling normal cell cycle progression and tumor suppression is well established, the clinical significance of p53 isoform expression is unknown. A novel bioinformatic analysis of p53 isoform expression in 68 patients with acute myeloid leukemia revealed distinct p53 protein biosignatures correlating with clinical outcome. Furthermore, we show that mutated FLT3, a prognostic marker for short survival in AML, is associated with expression of full-length p53. In contrast, mutated NPM1, a prognostic marker for long-term survival, correlated with p53 isoforms ? and ? expression. In conclusion, p53 biosignatures contain useful information for cancer evaluation and prognostication. © 2012 Macmillan Publishers Limited All rights reserved.
AB - The wild-type tumor-suppressor gene TP53 encodes several isoforms of the p53 protein. However, while the role of p53 in controlling normal cell cycle progression and tumor suppression is well established, the clinical significance of p53 isoform expression is unknown. A novel bioinformatic analysis of p53 isoform expression in 68 patients with acute myeloid leukemia revealed distinct p53 protein biosignatures correlating with clinical outcome. Furthermore, we show that mutated FLT3, a prognostic marker for short survival in AML, is associated with expression of full-length p53. In contrast, mutated NPM1, a prognostic marker for long-term survival, correlated with p53 isoforms ? and ? expression. In conclusion, p53 biosignatures contain useful information for cancer evaluation and prognostication. © 2012 Macmillan Publishers Limited All rights reserved.
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84858798570&md5=9bffcca6497db745d76787468a0f64e7
U2 - 10.1038/onc.2011.348
DO - 10.1038/onc.2011.348
M1 - Article
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 12
VL - 31
SP - 1533
EP - 1545
ER -