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Cranberry or trimethoprim for the prevention of recurrent urinary tract infections?

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Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? : A randomized controlled trial in older women. / McMurdo, Marion E. T. (Lead / Corresponding author); Argo, Ishbel; Phillips, Gabby; Daly, Fergus; Davey, Peter.

In: Journal of Antimicrobial Chemotherapy, Vol. 63, No. 2, 02.2009, p. 389-395.

Research output: Contribution to journalArticle

Harvard

McMurdo, MET, Argo, I, Phillips, G, Daly, F & Davey, P 2009, 'Cranberry or trimethoprim for the prevention of recurrent urinary tract infections?: A randomized controlled trial in older women' Journal of Antimicrobial Chemotherapy, vol 63, no. 2, pp. 389-395., 10.1093/jac/dkn489

APA

McMurdo, M. E. T., Argo, I., Phillips, G., Daly, F., & Davey, P. (2009). Cranberry or trimethoprim for the prevention of recurrent urinary tract infections?: A randomized controlled trial in older women. Journal of Antimicrobial Chemotherapy, 63(2), 389-395. 10.1093/jac/dkn489

Vancouver

McMurdo MET, Argo I, Phillips G, Daly F, Davey P. Cranberry or trimethoprim for the prevention of recurrent urinary tract infections?: A randomized controlled trial in older women. Journal of Antimicrobial Chemotherapy. 2009 Feb;63(2):389-395. Available from: 10.1093/jac/dkn489

Author

McMurdo, Marion E. T. (Lead / Corresponding author); Argo, Ishbel; Phillips, Gabby; Daly, Fergus; Davey, Peter / Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? : A randomized controlled trial in older women.

In: Journal of Antimicrobial Chemotherapy, Vol. 63, No. 2, 02.2009, p. 389-395.

Research output: Contribution to journalArticle

Bibtex - Download

@article{4f98216de4c844b78bf4fbaeb8ddcf87,
title = "Cranberry or trimethoprim for the prevention of recurrent urinary tract infections?: A randomized controlled trial in older women",
keywords = "PLACEBO-CONTROLLED TRIAL, DOUBLE-BLIND, RESISTANCE, JUICE",
author = "McMurdo, {Marion E. T.} and Ishbel Argo and Gabby Phillips and Fergus Daly and Peter Davey",
year = "2009",
doi = "10.1093/jac/dkn489",
volume = "63",
number = "2",
pages = "389--395",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Cranberry or trimethoprim for the prevention of recurrent urinary tract infections?

T2 - A randomized controlled trial in older women

A1 - McMurdo,Marion E. T.

A1 - Argo,Ishbel

A1 - Phillips,Gabby

A1 - Daly,Fergus

A1 - Davey,Peter

AU - McMurdo,Marion E. T.

AU - Argo,Ishbel

AU - Phillips,Gabby

AU - Daly,Fergus

AU - Davey,Peter

PY - 2009/2

Y1 - 2009/2

N2 - <p>To compare the effectiveness of cranberry extract with low-dose trimethoprim in the prevention of recurrent urinary tract infections (UTIs) in older women.</p><p>One hundred and thirty-seven women with two or more antibiotic-treated UTIs in the previous 12 months were randomized to receive either 500 mg of cranberry extract or 100 mg of trimethoprim for 6 months. Trial registration: ISRCTN80031108.</p><p>Thirty-nine of 137 participants (28%) had an antibiotic-treated UTI (25 in the cranberry group and 14 in the trimethoprim group); difference in proportions relative risk 1.616 (95% CI: 0.93, 2.79) P = 0.084. The time to first recurrence of UTI was not significantly different between the groups (P = 0.100). The median time to recurrence of UTI was 84.5 days for the cranberry group and 91 days for the trimethoprim group (U = 166, P = 0.479). There were 17/137 (12%) withdrawals from the study, 6/69 (9%) from the cranberry group and 11/68 (16%) from the trimethoprim group (P = 0.205), with a relative risk of withdrawal from the cranberry group of 0.54 (95% CI: 0.19, 1.37).</p><p>Trimethoprim had a very limited advantage over cranberry extract in the prevention of recurrent UTIs in older women and had more adverse effects. Our findings will allow older women with recurrent UTIs to weigh up with their clinicians the inherent attractions of a cheap, natural product like cranberry extract whose use does not carry the risk of antimicrobial resistance or super-infection with Clostridium difficile or fungi.</p>

AB - <p>To compare the effectiveness of cranberry extract with low-dose trimethoprim in the prevention of recurrent urinary tract infections (UTIs) in older women.</p><p>One hundred and thirty-seven women with two or more antibiotic-treated UTIs in the previous 12 months were randomized to receive either 500 mg of cranberry extract or 100 mg of trimethoprim for 6 months. Trial registration: ISRCTN80031108.</p><p>Thirty-nine of 137 participants (28%) had an antibiotic-treated UTI (25 in the cranberry group and 14 in the trimethoprim group); difference in proportions relative risk 1.616 (95% CI: 0.93, 2.79) P = 0.084. The time to first recurrence of UTI was not significantly different between the groups (P = 0.100). The median time to recurrence of UTI was 84.5 days for the cranberry group and 91 days for the trimethoprim group (U = 166, P = 0.479). There were 17/137 (12%) withdrawals from the study, 6/69 (9%) from the cranberry group and 11/68 (16%) from the trimethoprim group (P = 0.205), with a relative risk of withdrawal from the cranberry group of 0.54 (95% CI: 0.19, 1.37).</p><p>Trimethoprim had a very limited advantage over cranberry extract in the prevention of recurrent UTIs in older women and had more adverse effects. Our findings will allow older women with recurrent UTIs to weigh up with their clinicians the inherent attractions of a cheap, natural product like cranberry extract whose use does not carry the risk of antimicrobial resistance or super-infection with Clostridium difficile or fungi.</p>

KW - PLACEBO-CONTROLLED TRIAL

KW - DOUBLE-BLIND

KW - RESISTANCE

KW - JUICE

UR - http://www.scopus.com/inward/record.url?scp=58849110888&partnerID=8YFLogxK

U2 - 10.1093/jac/dkn489

DO - 10.1093/jac/dkn489

M1 - Article

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 2

VL - 63

SP - 389

EP - 395

ER -

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