Cross-talk between Transcription Factors AhR and Nrf2: Lessons for Cancer Chemoprevention from Dioxin

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

Hayes, J. D., McMahon, M., Chowdhry, S. & Dinkova-Kostova, A. T. 2010 In : Antioxidants & Redox Signaling. 13, 11, p. 1713-1748, 36 p.

Research output: Contribution to journal › Article

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A. & Hayes, J. D. 2012 In : Oncogene.

Research output: Contribution to journal › Article

Nrf2-mediated induction of antioxidant response element-driven gene expression by flavonoids is dependent on their chemical structure

Xiao, H., Hourihan, J. M., Brown, L., McMahon, M., Stewart, D. & Hayes, J. D. 18-Dec-2011 In : Toxicology. 290, 2-3, p. 126-127, 2 p.

Research output: Contribution to journal › Book/Film/Article review

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D. & Cuadrado, A. Mar-2011 In : Molecular and Cellular Biology. 31, 6, p. 1121-1133, 13 p.

Research output: Contribution to journal › Article

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

McMahon, M., Lamont, D. J., Beattie, K. A. & Hayes, J. D. 2-Nov-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 18838-18843, 6 p.

Research output: Contribution to journal › Article

Transgenic Animal Models in Toxicology: Historical Perspectives and Future Outlook

Boverhof, D. R., Chamberlain, M. P., Elcombe, C. R., Gonzalez, F. J., Heflich, R. H., Hernandez, L. G., Jacobs, A. C., Jacobson-Kram, D., Luijten, M., Maggi, A., Manjanatha, M. G., van Benthem, J. & Gollapudi, B. B. Jun-2011 In : Toxicological Sciences. 121, 2, p. 207-233, 27 p.

Research output: Contribution to journal › Article

Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May-2011 In : Toxicological Sciences. 121, 1, p. 43-56, 14 p.

Research output: Contribution to journal › Article

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug-2010 In : Toxicological Sciences. 116, 2, p. 452-466, 15 p.

Research output: Contribution to journal › Article

Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity

Cavin, C., Delatour, T., Marin-Kuan, M., Holzhäuser, D., Higgins, L., Bezençon, C., Guignard, G., Junod, S., Richoz-Payot, J., Gremaud, E., Hayes, J. D., Nestler, S., Mantle, P. & Schilter, B. 2007 In : Toxicological Sciences. 96, 1, p. 30-9, 10 p.

Research output: Contribution to journal › Article