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Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models

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Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models : modulatory effects of phytochemicals. / O'Brien, N. M.; Woods, J. A.; Aherne, S. A.; O'Callaghan, Y. C.

In: Biochemical Society Transactions, Vol. 28, No. 2, 2000, p. 22-26.

Research output: Contribution to journalArticle

Harvard

O'Brien, NM, Woods, JA, Aherne, SA & O'Callaghan, YC 2000, 'Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals' Biochemical Society Transactions, vol 28, no. 2, pp. 22-26.

APA

O'Brien, N. M., Woods, J. A., Aherne, S. A., & O'Callaghan, Y. C. (2000). Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. Biochemical Society Transactions, 28(2), 22-26doi: 10.1042/bst0280022

Vancouver

O'Brien NM, Woods JA, Aherne SA, O'Callaghan YC. Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals. Biochemical Society Transactions. 2000;28(2):22-26.

Author

O'Brien, N. M.; Woods, J. A.; Aherne, S. A.; O'Callaghan, Y. C. / Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models : modulatory effects of phytochemicals.

In: Biochemical Society Transactions, Vol. 28, No. 2, 2000, p. 22-26.

Research output: Contribution to journalArticle

Bibtex - Download

@article{91f6ff83dcaf40089ea9a14e40d2bf89,
title = "Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models",
author = "O'Brien, {N. M.} and Woods, {J. A.} and Aherne, {S. A.} and O'Callaghan, {Y. C.}",
year = "2000",
volume = "28",
number = "2",
pages = "22--26",
journal = "Biochemical Society Transactions",
issn = "0300-5127",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models

T2 - modulatory effects of phytochemicals

A1 - O'Brien,N. M.

A1 - Woods,J. A.

A1 - Aherne,S. A.

A1 - O'Callaghan,Y. C.

AU - O'Brien,N. M.

AU - Woods,J. A.

AU - Aherne,S. A.

AU - O'Callaghan,Y. C.

PY - 2000

Y1 - 2000

N2 - Much research effort has focused on the identification of phytochemicals in fruit and vegetables which exert beneficial effects. Our research examines modulatory effects of phytochemicals on cytotoxicity, genotoxicity and oxidative reactions in cell systems. Two examples of our studies are discussed. First, the potential beneficial effects of flavonoids are demonstrated. Flavonoids are reported to exhibit a wide variety of biological effects, including antioxidant and free-radical-scavenging activities. The aim of the study was to determine if flavonoids could protect against H2O2-induced DNA damage, as measured by the comet assay, in Caco-2 and HepG2 cells. Both cell lines were supplemented with increasing concentrations of myricetin, quercetin and rutin for 24 h followed by exposure to H2O2 (50 microM) for 30 min. Exposure to H2O2 for 30 min at 37 degrees C resulted in significant DNA damage and pre-incubation with the flavonoids before H2O2 exposure significantly (P

AB - Much research effort has focused on the identification of phytochemicals in fruit and vegetables which exert beneficial effects. Our research examines modulatory effects of phytochemicals on cytotoxicity, genotoxicity and oxidative reactions in cell systems. Two examples of our studies are discussed. First, the potential beneficial effects of flavonoids are demonstrated. Flavonoids are reported to exhibit a wide variety of biological effects, including antioxidant and free-radical-scavenging activities. The aim of the study was to determine if flavonoids could protect against H2O2-induced DNA damage, as measured by the comet assay, in Caco-2 and HepG2 cells. Both cell lines were supplemented with increasing concentrations of myricetin, quercetin and rutin for 24 h followed by exposure to H2O2 (50 microM) for 30 min. Exposure to H2O2 for 30 min at 37 degrees C resulted in significant DNA damage and pre-incubation with the flavonoids before H2O2 exposure significantly (P

U2 - 10.1042/bst0280022

DO - 10.1042/bst0280022

M1 - Article

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 2

VL - 28

SP - 22

EP - 26

ER -

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