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Delta 160p53 is a novel N-terminal p53 isoform encoded by Delta 133p53 transcript

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Delta 160p53 is a novel N-terminal p53 isoform encoded by Delta 133p53 transcript. / Marcel, Virginie; Perrier, Stephane; Aoubala, Mustapha; Ageorges, Sylvain; Groves, Michael J.; Diot, Alexandra; Fernandes, Kenneth; Tauro, Sudhir; Bourdon, Jean-Christophe.

In: FEBS Letters, Vol. 584, No. 21, 05.11.2010, p. 4463-4468.

Research output: Contribution to journalArticle

Harvard

Marcel, V, Perrier, S, Aoubala, M, Ageorges, S, Groves, MJ, Diot, A, Fernandes, K, Tauro, S & Bourdon, J-C 2010, 'Delta 160p53 is a novel N-terminal p53 isoform encoded by Delta 133p53 transcript' FEBS Letters, vol 584, no. 21, pp. 4463-4468.

APA

Marcel, V., Perrier, S., Aoubala, M., Ageorges, S., Groves, M. J., Diot, A., Fernandes, K., Tauro, S., & Bourdon, J-C. (2010). Delta 160p53 is a novel N-terminal p53 isoform encoded by Delta 133p53 transcript. FEBS Letters, 584(21), 4463-4468doi: 10.1016/j.febslet.2010.10.005

Vancouver

Marcel V, Perrier S, Aoubala M, Ageorges S, Groves MJ, Diot A et al. Delta 160p53 is a novel N-terminal p53 isoform encoded by Delta 133p53 transcript. FEBS Letters. 2010 Nov 5;584(21):4463-4468.

Author

Marcel, Virginie; Perrier, Stephane; Aoubala, Mustapha; Ageorges, Sylvain; Groves, Michael J.; Diot, Alexandra; Fernandes, Kenneth; Tauro, Sudhir; Bourdon, Jean-Christophe / Delta 160p53 is a novel N-terminal p53 isoform encoded by Delta 133p53 transcript.

In: FEBS Letters, Vol. 584, No. 21, 05.11.2010, p. 4463-4468.

Research output: Contribution to journalArticle

Bibtex - Download

@article{3b3beb050a364290ae697c6a47fa2563,
title = "Delta 160p53 is a novel N-terminal p53 isoform encoded by Delta 133p53 transcript",
author = "Virginie Marcel and Stephane Perrier and Mustapha Aoubala and Sylvain Ageorges and Groves, {Michael J.} and Alexandra Diot and Kenneth Fernandes and Sudhir Tauro and Jean-Christophe Bourdon",
year = "2010",
volume = "584",
number = "21",
pages = "4463--4468",
journal = "FEBS Letters",
issn = "0014-5793",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Delta 160p53 is a novel N-terminal p53 isoform encoded by Delta 133p53 transcript

A1 - Marcel,Virginie

A1 - Perrier,Stephane

A1 - Aoubala,Mustapha

A1 - Ageorges,Sylvain

A1 - Groves,Michael J.

A1 - Diot,Alexandra

A1 - Fernandes,Kenneth

A1 - Tauro,Sudhir

A1 - Bourdon,Jean-Christophe

AU - Marcel,Virginie

AU - Perrier,Stephane

AU - Aoubala,Mustapha

AU - Ageorges,Sylvain

AU - Groves,Michael J.

AU - Diot,Alexandra

AU - Fernandes,Kenneth

AU - Tauro,Sudhir

AU - Bourdon,Jean-Christophe

PY - 2010/11/5

Y1 - 2010/11/5

N2 - <p>p53 gene expresses several protein isoforms modulating p53-mediated responses through regulation of gene expression. Here, we identify a novel p53 isoform, Delta 160p53, lacking the first 159 residues. By knockdown experiments and site-directed mutagenesis, we show that Delta 160p53 is encoded by Delta 133p53 transcript using ATG160 as translational initiation site. This hypothesis is supported by endogenous expression of Delta 160p53 in U2OS, T47D and K562 cells, the latter ones carrying a premature stop codon that impairs p53 and Delta 133p53 protein expression but not the one of Delta 160p53. Overall, these results show that the Delta 133p53 transcript generates two different p53 isoforms, Delta 133p53 and Delta 160p53. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</p>

AB - <p>p53 gene expresses several protein isoforms modulating p53-mediated responses through regulation of gene expression. Here, we identify a novel p53 isoform, Delta 160p53, lacking the first 159 residues. By knockdown experiments and site-directed mutagenesis, we show that Delta 160p53 is encoded by Delta 133p53 transcript using ATG160 as translational initiation site. This hypothesis is supported by endogenous expression of Delta 160p53 in U2OS, T47D and K562 cells, the latter ones carrying a premature stop codon that impairs p53 and Delta 133p53 protein expression but not the one of Delta 160p53. Overall, these results show that the Delta 133p53 transcript generates two different p53 isoforms, Delta 133p53 and Delta 160p53. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</p>

KW - p53

KW - Tumour suppressor

KW - Delta 160p53

KW - Delta 133p53

KW - CELLS

KW - GENE

U2 - 10.1016/j.febslet.2010.10.005

DO - 10.1016/j.febslet.2010.10.005

M1 - Article

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 21

VL - 584

SP - 4463

EP - 4468

ER -

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