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Depression models

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Depression models. / Matthews, K.; Stewart, C.

Encyclopedia of stress. ed. / George Fink. 2nd. ed. New York : Academic Press, 2007. p. 760-766.

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Harvard

Matthews, K & Stewart, C 2007, 'Depression models'. in G Fink (ed.), Encyclopedia of stress. 2nd edn, Academic Press, New York, pp. 760-766.

APA

Matthews, K., & Stewart, C. (2007). Depression models. In Fink, G. (Ed.), Encyclopedia of stress. (2nd ed.) (pp. 760-766). New York: Academic Press. doi: 10.1016/B978-012373947-6.00118-5

Vancouver

Matthews K, Stewart C. Depression models. In Fink G, editor, Encyclopedia of stress. 2nd ed. New York: Academic Press. 2007. p. 760-766.

Author

Matthews, K.; Stewart, C. / Depression models.

Encyclopedia of stress. ed. / George Fink. 2nd. ed. New York : Academic Press, 2007. p. 760-766.

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Bibtex - Download

@inbook{80cb1d1b534e4ac6b3c259045beaa5c5,
title = "Depression models",
publisher = "Academic Press",
author = "K. Matthews and C. Stewart",
note = "This article is a revision of the previous edition article by K Matthews, volume 1, pp 675–681, © 2000, Elsevier Inc.",
year = "2007",
editor = "George Fink",
edition = "2nd",
isbn = "9780123739476",
pages = "760-766",
booktitle = "Encyclopedia of stress",

}

RIS (suitable for import to EndNote) - Download

TY - CHAP

T1 - Depression models

A1 - Matthews,K.

A1 - Stewart,C.

AU - Matthews,K.

AU - Stewart,C.

PB - Academic Press

CY - New York

PY - 2007

Y1 - 2007

N2 - The brain pathologies that mediate the cognitive, motivational, and motor abnormalities of depressive disorders remain elusive. Similarly, the brain mechanisms that confer individual vulnerability to stress and those that precipitate and sustain clinical depression are poorly understood. One approach to these problems has been to try and model the complex neurobiological and behavioral alterations associated with human depression in laboratory animals. Thus, the term depression model refers to any experimental preparation that facilitates the study of human depression-related phenomena by comparing target behaviors and biological functions across species. Usually this involves the generation of behavioral or physiological changes in laboratory animals following an explicit intervention, such as the application of stress. It should be emphasized that such models of a complex disease state need not actually (and are in fact not likely to) produce the disease in the laboratory animal. It is sufficient that a depression model strive to reproduce one critical aspect of the disease process. Similarly, it is not essential that the phenomenon under study demonstrate a response to antidepressant drug administration (unless this is the purpose of the model) although this is often sought. This overview of depression models first addresses general theoretical considerations concerning the validity of the approach, followed by a review of candidate neural mechanisms through which stress might influence behavioral responses to reward. This is followed by a brief review of stress-based animal models of depression.

AB - The brain pathologies that mediate the cognitive, motivational, and motor abnormalities of depressive disorders remain elusive. Similarly, the brain mechanisms that confer individual vulnerability to stress and those that precipitate and sustain clinical depression are poorly understood. One approach to these problems has been to try and model the complex neurobiological and behavioral alterations associated with human depression in laboratory animals. Thus, the term depression model refers to any experimental preparation that facilitates the study of human depression-related phenomena by comparing target behaviors and biological functions across species. Usually this involves the generation of behavioral or physiological changes in laboratory animals following an explicit intervention, such as the application of stress. It should be emphasized that such models of a complex disease state need not actually (and are in fact not likely to) produce the disease in the laboratory animal. It is sufficient that a depression model strive to reproduce one critical aspect of the disease process. Similarly, it is not essential that the phenomenon under study demonstrate a response to antidepressant drug administration (unless this is the purpose of the model) although this is often sought. This overview of depression models first addresses general theoretical considerations concerning the validity of the approach, followed by a review of candidate neural mechanisms through which stress might influence behavioral responses to reward. This is followed by a brief review of stress-based animal models of depression.

U2 - 10.1016/B978-012373947-6.00118-5

DO - 10.1016/B978-012373947-6.00118-5

M1 - Entry for encyclopedia/dictionary

SN - 9780123739476

BT - Encyclopedia of stress

T2 - Encyclopedia of stress

A2 - Fink,George

ED - Fink,George

SP - 760

EP - 766

ER -

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