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Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography

Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography

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Original languageEnglish
Article number126003
Number of pages9
JournalJournal of Biomedical Optics
Journal publication date28 Nov 2011
Volume16
Issue12
DOIs
StatePublished

Abstract

A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography system, which detects the changes in the optical path length of the sample induced by the temperature increase. The model is theoretically derived and the coefficients are empirically determined using solid homogeneous gel phantoms. The model is validated by reconstructing the concentration of a photothermal compound in thick single and double layer solid phantoms.

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