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Do HPV-negative cervical carcinomas exist? - revisited

Do HPV-negative cervical carcinomas exist? - revisited

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  • C. Simon Herrington

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Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalJournal of Pathology
Issue number1
StatePublished - 1999


There has been considerable debate regarding the existence of HPV-negative cervical carcinoma. In this issue of the journal, using well-controlled methodology, Walboomers et al. demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV-negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening. Copyright (C) 1999 John Wiley & Sons, Ltd.


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