Do men develop type 2 diabetes at lower body mass indices than women?. / Logue, J.; Walker, J. J.; Colhoun, H. M.; Leese, G. P.; Lindsay, R. S.; McKnight, J. A.; Morris, A. D.; Pearson, D. W.; Petrie, J. R.; Philip, S.; Wild, S. H.; Sattar, N.; Scottish Diabetes Research Network Epidemiology Group.
In: Diabetologia, Vol. 54, No. 12, 12.2011, p. 3003-3006.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Do men develop type 2 diabetes at lower body mass indices than women?
A1 - Logue,J.
A1 - Walker,J. J.
A1 - Colhoun,H. M.
A1 - Leese,G. P.
A1 - Lindsay,R. S.
A1 - McKnight,J. A.
A1 - Morris,A. D.
A1 - Pearson,D. W.
A1 - Petrie,J. R.
A1 - Philip,S.
A1 - Wild,S. H.
A1 - Sattar,N.
A1 - Scottish Diabetes Research Network Epidemiology Group
AU - Logue,J.
AU - Walker,J. J.
AU - Colhoun,H. M.
AU - Leese,G. P.
AU - Lindsay,R. S.
AU - McKnight,J. A.
AU - Morris,A. D.
AU - Pearson,D. W.
AU - Petrie,J. R.
AU - Philip,S.
AU - Wild,S. H.
AU - Sattar,N.
AU - Scottish Diabetes Research Network Epidemiology Group
PY - 2011/12
Y1 - 2011/12
N2 - <p>Aims/hypothesis To describe the associations between age, sex and BMI at diagnosis of type 2 diabetes, and test the hypothesis that men are diagnosed with diabetes at lower average BMI than women of similar age.</p><p>Methods Linear regression was used to estimate and compare the relationship between age and BMI at diagnosis among 51,920 men and 43,137 women included in a population-based diabetes register in Scotland for whom an index BMI measurement was taken within 1 year of diabetes diagnosis. We also examined HbA(1c) values by sex within the same timescale.</p><p>Results Mean BMI closest to date of diagnosis of type 2 diabetes mellitus was 31.83 kg/m(2) (SD 5.13) in men and 33.69 kg/m(2) (SD 6.43) in women. The inverse relationship between age and BMI at diagnosis of type 2 diabetes mellitus was significantly steeper in women than in men (slope estimate in men -0.12 kg/m(2) per year [95% CI -0.13, -0.12] women -0.18 kg/m(2) per year [95% CI -0.18, -0.17], p<0.0001 for formal test of interaction). Mean BMI difference was most marked at younger ages and narrowed with advancing age. However, HbA(1c) levels within 1 year of diagnoses were broadly similar in men and women.</p><p>Conclusions/interpretation Men are diagnosed with type 2 diabetes at lower BMI than women across the age range. This observation may help explain why type 2 diabetes is more common among middle-aged men in populations of European extraction. Whether the same pattern is also observed in other ethnic groups requires confirmation.</p>
AB - <p>Aims/hypothesis To describe the associations between age, sex and BMI at diagnosis of type 2 diabetes, and test the hypothesis that men are diagnosed with diabetes at lower average BMI than women of similar age.</p><p>Methods Linear regression was used to estimate and compare the relationship between age and BMI at diagnosis among 51,920 men and 43,137 women included in a population-based diabetes register in Scotland for whom an index BMI measurement was taken within 1 year of diabetes diagnosis. We also examined HbA(1c) values by sex within the same timescale.</p><p>Results Mean BMI closest to date of diagnosis of type 2 diabetes mellitus was 31.83 kg/m(2) (SD 5.13) in men and 33.69 kg/m(2) (SD 6.43) in women. The inverse relationship between age and BMI at diagnosis of type 2 diabetes mellitus was significantly steeper in women than in men (slope estimate in men -0.12 kg/m(2) per year [95% CI -0.13, -0.12] women -0.18 kg/m(2) per year [95% CI -0.18, -0.17], p<0.0001 for formal test of interaction). Mean BMI difference was most marked at younger ages and narrowed with advancing age. However, HbA(1c) levels within 1 year of diagnoses were broadly similar in men and women.</p><p>Conclusions/interpretation Men are diagnosed with type 2 diabetes at lower BMI than women across the age range. This observation may help explain why type 2 diabetes is more common among middle-aged men in populations of European extraction. Whether the same pattern is also observed in other ethnic groups requires confirmation.</p>
KW - Body mass index
KW - Diagnosis
KW - Insulin resistance
KW - Sex
KW - Vascular disease
KW - Population
KW - Risk
U2 - 10.1007/s00125-011-2313-3
DO - 10.1007/s00125-011-2313-3
M1 - Article
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 12
VL - 54
SP - 3003
EP - 3006
ER -