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Early treatment with prednisolone or acyclovir in Bell's palsy

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Early treatment with prednisolone or acyclovir in Bell's palsy. / Sullivan, Frank M.; Swan, Iain R. C.; Donnan, Peter T.; Morrison, Jillian M.; Smith, Blair; McKinstry, Brian; Davenport, Richard J.; Vale, Luke D.; Clarkson, Janet E.; Hammersley, Victoria; Hayavi, Sima; McAteer, Anne; Stewart, Ken; Daly, Fergus.

In: New England Journal of Medicine, Vol. 357, No. 16, 18.10.2007, p. 1598-1607.

Research output: Contribution to journalArticle

Harvard

Sullivan, FM, Swan, IRC, Donnan, PT, Morrison, JM, Smith, B, McKinstry, B, Davenport, RJ, Vale, LD, Clarkson, JE, Hammersley, V, Hayavi, S, McAteer, A, Stewart, K & Daly, F 2007, 'Early treatment with prednisolone or acyclovir in Bell's palsy' New England Journal of Medicine, vol 357, no. 16, pp. 1598-1607.

APA

Sullivan, F. M., Swan, I. R. C., Donnan, P. T., Morrison, J. M., Smith, B., McKinstry, B., Davenport, R. J., Vale, L. D., Clarkson, J. E., Hammersley, V., Hayavi, S., McAteer, A., Stewart, K., & Daly, F. (2007). Early treatment with prednisolone or acyclovir in Bell's palsy. New England Journal of Medicine, 357(16), 1598-1607doi: 10.1056/NEJMoa072006

Vancouver

Sullivan FM, Swan IRC, Donnan PT, Morrison JM, Smith B, McKinstry B et al. Early treatment with prednisolone or acyclovir in Bell's palsy. New England Journal of Medicine. 2007 Oct 18;357(16):1598-1607.

Author

Sullivan, Frank M.; Swan, Iain R. C.; Donnan, Peter T.; Morrison, Jillian M.; Smith, Blair; McKinstry, Brian; Davenport, Richard J.; Vale, Luke D.; Clarkson, Janet E.; Hammersley, Victoria; Hayavi, Sima; McAteer, Anne; Stewart, Ken; Daly, Fergus / Early treatment with prednisolone or acyclovir in Bell's palsy.

In: New England Journal of Medicine, Vol. 357, No. 16, 18.10.2007, p. 1598-1607.

Research output: Contribution to journalArticle

Bibtex - Download

@article{b7c00bcd746b4f1ca5c6d63edc959bf2,
title = "Early treatment with prednisolone or acyclovir in Bell's palsy",
author = "Sullivan, {Frank M.} and Swan, {Iain R. C.} and Donnan, {Peter T.} and Morrison, {Jillian M.} and Blair Smith and Brian McKinstry and Davenport, {Richard J.} and Vale, {Luke D.} and Clarkson, {Janet E.} and Victoria Hammersley and Sima Hayavi and Anne McAteer and Ken Stewart and Fergus Daly",
year = "2007",
volume = "357",
number = "16",
pages = "1598--1607",
journal = "New England Journal of Medicine",
issn = "0028-4793",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Early treatment with prednisolone or acyclovir in Bell's palsy

A1 - Sullivan,Frank M.

A1 - Swan,Iain R. C.

A1 - Donnan,Peter T.

A1 - Morrison,Jillian M.

A1 - Smith,Blair

A1 - McKinstry,Brian

A1 - Davenport,Richard J.

A1 - Vale,Luke D.

A1 - Clarkson,Janet E.

A1 - Hammersley,Victoria

A1 - Hayavi,Sima

A1 - McAteer,Anne

A1 - Stewart,Ken

A1 - Daly,Fergus

AU - Sullivan,Frank M.

AU - Swan,Iain R. C.

AU - Donnan,Peter T.

AU - Morrison,Jillian M.

AU - Smith,Blair

AU - McKinstry,Brian

AU - Davenport,Richard J.

AU - Vale,Luke D.

AU - Clarkson,Janet E.

AU - Hammersley,Victoria

AU - Hayavi,Sima

AU - McAteer,Anne

AU - Stewart,Ken

AU - Daly,Fergus

PY - 2007/10/18

Y1 - 2007/10/18

N2 - <p>Background</p><p>Corticosteroids and antiviral agents are widely used to treat the early stages of idiopathic facial paralysis (i.e., Bell's palsy), but their effectiveness is uncertain.</p><p>Methods</p><p>We conducted a double-blind, placebo-controlled, randomized, factorial trial involving patients with Bell's palsy who were recruited within 72 hours after the onset of symptoms. Patients were randomly assigned to receive 10 days of treatment with prednisolone, acyclovir, both agents, or placebo. The primary outcome was recovery of facial function, as rated on the House-Brackmann scale. Secondary outcomes included quality of life, appearance, and pain.</p><p>Results</p><p>Final outcomes were assessed for 496 of 551 patients who underwent randomization. At 3 months, the proportions of patients who had recovered facial function were 83.0% in the prednisolone group as compared with 63.6% among patients who did not receive prednisolone (P&lt;0.001) and 71.2% in the acyclovir group as compared with 75.7% among patients who did not receive acyclovir (adjusted P=0.50). After 9 months, these proportions were 94.4% for prednisolone and 81.6% for no prednisolone (P&lt;0.001) and 85.4% for acyclovir and 90.8% for no acyclovir (adjusted P=0.10). For patients treated with both drugs, the proportions were 79.7% at 3 months (P&lt;0.001) and 92.7% at 9 months (P&lt;0.001). There were no clinically significant differences between the treatment groups in secondary outcomes. There were no serious adverse events in any group.</p><p>Conclusions</p><p>In patients with Bell's palsy, early treatment with prednisolone significantly improves the chances of complete recovery at 3 and 9 months. There is no evidence of a benefit of acyclovir given alone or an additional benefit of acyclovir in combination with prednisolone.</p>

AB - <p>Background</p><p>Corticosteroids and antiviral agents are widely used to treat the early stages of idiopathic facial paralysis (i.e., Bell's palsy), but their effectiveness is uncertain.</p><p>Methods</p><p>We conducted a double-blind, placebo-controlled, randomized, factorial trial involving patients with Bell's palsy who were recruited within 72 hours after the onset of symptoms. Patients were randomly assigned to receive 10 days of treatment with prednisolone, acyclovir, both agents, or placebo. The primary outcome was recovery of facial function, as rated on the House-Brackmann scale. Secondary outcomes included quality of life, appearance, and pain.</p><p>Results</p><p>Final outcomes were assessed for 496 of 551 patients who underwent randomization. At 3 months, the proportions of patients who had recovered facial function were 83.0% in the prednisolone group as compared with 63.6% among patients who did not receive prednisolone (P&lt;0.001) and 71.2% in the acyclovir group as compared with 75.7% among patients who did not receive acyclovir (adjusted P=0.50). After 9 months, these proportions were 94.4% for prednisolone and 81.6% for no prednisolone (P&lt;0.001) and 85.4% for acyclovir and 90.8% for no acyclovir (adjusted P=0.10). For patients treated with both drugs, the proportions were 79.7% at 3 months (P&lt;0.001) and 92.7% at 9 months (P&lt;0.001). There were no clinically significant differences between the treatment groups in secondary outcomes. There were no serious adverse events in any group.</p><p>Conclusions</p><p>In patients with Bell's palsy, early treatment with prednisolone significantly improves the chances of complete recovery at 3 and 9 months. There is no evidence of a benefit of acyclovir given alone or an additional benefit of acyclovir in combination with prednisolone.</p>

UR - http://www.nejm.org/doi/full/10.1056/NEJMoa073204

U2 - 10.1056/NEJMoa072006

DO - 10.1056/NEJMoa072006

M1 - Article

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 16

VL - 357

SP - 1598

EP - 1607

ER -

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