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Effects of hydrocortisone on acute β-adrenoceptor blocker and histamine induced bronchoconstriction

Effects of hydrocortisone on acute β-adrenoceptor blocker and histamine induced bronchoconstriction

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Original languageEnglish
Pages (from-to)717-726
Number of pages10
JournalBritish Journal of Clinical Pharmacology
Volume73
Issue number5
DOIs
StatePublished - May 2012

Abstract

ß-adrenoceptor blockers are avoided in asthma due to concerns of bronchoconstriction. We investigated the safety of acute exposure to propranolol in asthmatics, sequentially challenged with histamine to mimic an asthma exacerbation and evaluated the role of intravenous hydrocortisone in potentiating salbutamol reversibility.

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