Efficacy and cost of an exercise program for functionally impaired older patients with heart failure : a randomized controlled trial. / Witham, Miles D.; Fulton, Roberta L.; Greig, Carol A.; Johnston, Derek W.; Lang, Chim C.; van der Pol, Marjon; Boyers, Dwayne; Struthers, Allan D.; McMurdo, Marion E. T.
In: Circulation: Heart Failure, Vol. 5, No. 2, 2012, p. 209-216.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Efficacy and cost of an exercise program for functionally impaired older patients with heart failure
T2 - a randomized controlled trial
A1 - Witham,Miles D.
A1 - Fulton,Roberta L.
A1 - Greig,Carol A.
A1 - Johnston,Derek W.
A1 - Lang,Chim C.
A1 - van der Pol,Marjon
A1 - Boyers,Dwayne
A1 - Struthers,Allan D.
A1 - McMurdo,Marion E. T.
AU - Witham,Miles D.
AU - Fulton,Roberta L.
AU - Greig,Carol A.
AU - Johnston,Derek W.
AU - Lang,Chim C.
AU - van der Pol,Marjon
AU - Boyers,Dwayne
AU - Struthers,Allan D.
AU - McMurdo,Marion E. T.
PY - 2012
Y1 - 2012
N2 - <p>Background-Little is known about the optimum way to deliver exercise to older, functionally impaired patients with heart failure. We tested whether an exercise program tailored to the needs of these patients could improve exercise capacity and quality of life or reduce costs to the National Health Service.</p><p>Methods and Results-The study design was a parallel-group, single-blind, randomized controlled trial. Patients aged >= 70 years with symptomatic heart failure and left ventricular systolic dysfunction were randomized to either 24 weeks of exercise training or usual care. Six-minute walk distance was the primary outcome; markers of physical function, quality of life, health status, and daily activity were measured at baseline and 8 and 24 weeks. Carer strain and healthcare costs were also recorded. A total of 107 participants were randomized (mean age, 80 years; men, 72 [67%]). Six-minute walk distance did not improve compared to that of the control group at 8 weeks (-16.9 m; 95% CI, -41.8 to 7.9 m; P=0.18) or at 24 weeks (-5.3 m; 95% CI, -32.6 to 22.0 m; P=0.70). For secondary outcomes, only the sit-to-stand test improved significantly at 24 weeks (-6.4 s; 95% CI, -12.2 to 0.6 s; P=0.03); there was no difference in change for the Minnesota Living With Heart Failure score (0.1 points; 95% CI, -0.9 to 1.1 points; P=0.83) at 24 weeks. Carer strain did not decrease at 24 weeks (difference, -0.5 points; 95% CI, -8.3 to 7.3 points; P=0.80), and there was no difference in overall healthcare costs.</p><p>Conclusions-This exercise intervention did not improve exercise capacity or quality of life in older patients with heart failure and was not cost saving to the National Health Service.</p>
AB - <p>Background-Little is known about the optimum way to deliver exercise to older, functionally impaired patients with heart failure. We tested whether an exercise program tailored to the needs of these patients could improve exercise capacity and quality of life or reduce costs to the National Health Service.</p><p>Methods and Results-The study design was a parallel-group, single-blind, randomized controlled trial. Patients aged >= 70 years with symptomatic heart failure and left ventricular systolic dysfunction were randomized to either 24 weeks of exercise training or usual care. Six-minute walk distance was the primary outcome; markers of physical function, quality of life, health status, and daily activity were measured at baseline and 8 and 24 weeks. Carer strain and healthcare costs were also recorded. A total of 107 participants were randomized (mean age, 80 years; men, 72 [67%]). Six-minute walk distance did not improve compared to that of the control group at 8 weeks (-16.9 m; 95% CI, -41.8 to 7.9 m; P=0.18) or at 24 weeks (-5.3 m; 95% CI, -32.6 to 22.0 m; P=0.70). For secondary outcomes, only the sit-to-stand test improved significantly at 24 weeks (-6.4 s; 95% CI, -12.2 to 0.6 s; P=0.03); there was no difference in change for the Minnesota Living With Heart Failure score (0.1 points; 95% CI, -0.9 to 1.1 points; P=0.83) at 24 weeks. Carer strain did not decrease at 24 weeks (difference, -0.5 points; 95% CI, -8.3 to 7.3 points; P=0.80), and there was no difference in overall healthcare costs.</p><p>Conclusions-This exercise intervention did not improve exercise capacity or quality of life in older patients with heart failure and was not cost saving to the National Health Service.</p>
U2 - 10.1161/CIRCHEARTFAILURE.111.963132
DO - 10.1161/CIRCHEARTFAILURE.111.963132
M1 - Article
JO - Circulation: Heart Failure
JF - Circulation: Heart Failure
SN - 1941-3289
IS - 2
VL - 5
SP - 209
EP - 216
ER -