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Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder

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Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder. / Perrin, Jennifer S.; Merz, Susanne; Bennett, Daniel M.; Currie, James; Steele, Douglas J.; Reid, Ian C.; Schwarzbauer, Christian.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 14, 03.04.2012, p. 5464-5468.

Research output: Contribution to journalArticle

Harvard

Perrin, JS, Merz, S, Bennett, DM, Currie, J, Steele, DJ, Reid, IC & Schwarzbauer, C 2012, 'Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder' Proceedings of the National Academy of Sciences of the United States of America, vol 109, no. 14, pp. 5464-5468., 10.1073/pnas.1117206109

APA

Perrin, J. S., Merz, S., Bennett, D. M., Currie, J., Steele, D. J., Reid, I. C., & Schwarzbauer, C. (2012). Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder. Proceedings of the National Academy of Sciences of the United States of America, 109(14), 5464-5468. 10.1073/pnas.1117206109

Vancouver

Perrin JS, Merz S, Bennett DM, Currie J, Steele DJ, Reid IC et al. Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder. Proceedings of the National Academy of Sciences of the United States of America. 2012 Apr 3;109(14):5464-5468. Available from: 10.1073/pnas.1117206109

Author

Perrin, Jennifer S.; Merz, Susanne; Bennett, Daniel M.; Currie, James; Steele, Douglas J.; Reid, Ian C.; Schwarzbauer, Christian / Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 14, 03.04.2012, p. 5464-5468.

Research output: Contribution to journalArticle

Bibtex - Download

@article{3e4da05c801443f3b90113fcd53c0636,
title = "Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder",
author = "Perrin, {Jennifer S.} and Susanne Merz and Bennett, {Daniel M.} and James Currie and Steele, {Douglas J.} and Reid, {Ian C.} and Christian Schwarzbauer",
year = "2012",
doi = "10.1073/pnas.1117206109",
volume = "109",
number = "14",
pages = "5464--5468",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder

A1 - Perrin,Jennifer S.

A1 - Merz,Susanne

A1 - Bennett,Daniel M.

A1 - Currie,James

A1 - Steele,Douglas J.

A1 - Reid,Ian C.

A1 - Schwarzbauer,Christian

AU - Perrin,Jennifer S.

AU - Merz,Susanne

AU - Bennett,Daniel M.

AU - Currie,James

AU - Steele,Douglas J.

AU - Reid,Ian C.

AU - Schwarzbauer,Christian

PY - 2012/4/3

Y1 - 2012/4/3

N2 - <p>To date, electroconvulsive therapy (ECT) is the most potent treatment in severe depression. Although ECT has been successfully applied in clinical practice for over 70 years, the underlying mechanisms of action remain unclear. We used functional MRI and a unique data-driven analysis approach to examine functional connectivity in the brain before and after ECT treatment. Our results show that ECT has lasting effects on the functional architecture of the brain. A comparison of pre- and posttreatment functional connectivity data in a group of nine patients revealed a significant cluster of voxels in and around the left dorsolateral prefrontal cortical region (Brodmann areas 44, 45, and 46), where the average global functional connectivity was considerably decreased after ECT treatment (P &lt; 0.05, family-wise error-corrected). This decrease in functional connectivity was accompanied by a significant improvement (P &lt; 0.001) in depressive symptoms; the patients' mean scores on the Montgomery Asberg Depression Rating Scale pre- and posttreatment were 36.4 (SD = 4.9) and 10.7 (SD = 9.6), respectively. The findings reported here add weight to the emerging "hyperconnectivity hypothesis" in depression and support the proposal that increased connectivity may constitute both a bio-marker for mood disorder and a potential therapeutic target.</p>

AB - <p>To date, electroconvulsive therapy (ECT) is the most potent treatment in severe depression. Although ECT has been successfully applied in clinical practice for over 70 years, the underlying mechanisms of action remain unclear. We used functional MRI and a unique data-driven analysis approach to examine functional connectivity in the brain before and after ECT treatment. Our results show that ECT has lasting effects on the functional architecture of the brain. A comparison of pre- and posttreatment functional connectivity data in a group of nine patients revealed a significant cluster of voxels in and around the left dorsolateral prefrontal cortical region (Brodmann areas 44, 45, and 46), where the average global functional connectivity was considerably decreased after ECT treatment (P &lt; 0.05, family-wise error-corrected). This decrease in functional connectivity was accompanied by a significant improvement (P &lt; 0.001) in depressive symptoms; the patients' mean scores on the Montgomery Asberg Depression Rating Scale pre- and posttreatment were 36.4 (SD = 4.9) and 10.7 (SD = 9.6), respectively. The findings reported here add weight to the emerging "hyperconnectivity hypothesis" in depression and support the proposal that increased connectivity may constitute both a bio-marker for mood disorder and a potential therapeutic target.</p>

U2 - 10.1073/pnas.1117206109

DO - 10.1073/pnas.1117206109

M1 - Article

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 14

VL - 109

SP - 5464

EP - 5468

ER -

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