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Engineered biocompatible nanoparticles for in vivo imaging applications

Engineered biocompatible nanoparticles for in vivo imaging applications

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Authors

  • Shu Chen
  • Lijun Wang
  • Suzanne L. Duce
  • Stuart Brown
  • Stephen Lee
  • Andreas Melzer
  • Alfred Cuschieri
  • Pascal Andre

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Info

Original languageEnglish
Pages15022-15029
Number of pages8
JournalJournal of the American Chemical Society
Journal publication date27 Oct 2010
Volume132
Issue42
DOIs
StatePublished

Abstract

Iron-platinum alloy nanoparticles (FePt NPs) are extremely promising candidates for the next generation of contrast agents for magnetic resonance (MR) diagnostic imaging and MR-guided interventions, including hyperthermic ablation of solid cancers. FePt has high Curie temperature, saturation magnetic moment, magneto-crystalline anisotropy, and chemical stability. We describe the synthesis and characterization of a family of biocompatible FePt NPs suitable for biomedical applications, showing and discussing that FePt NPs can exhibit low cytotoxicity. The importance of engineering the interface of strongly magnetic NPs using a coating allowing free aqueous permeation is demonstrated to be an essential parameter in the design of new generations of diagnostic and therapeutic MRI contrast agents. We report effective cell internalization of FePt NPs and demonstrate that they can be used for cellular imaging and in vivo MRI applications. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging.

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