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Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate

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Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate. / Elcombe, Clifford R.; Elcombe, Barbara M.; Foster, John R.; Chang, Shu-Ching; Ehresman, David J.; Noker, Patricia E.; Butenhoff, John L.

In: Toxicology, Vol. 293, No. 1-3, 11.03.2012, p. 30-40.

Research output: Contribution to journalArticle

Harvard

Elcombe, CR, Elcombe, BM, Foster, JR, Chang, S-C, Ehresman, DJ, Noker, PE & Butenhoff, JL 2012, 'Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate' Toxicology, vol 293, no. 1-3, pp. 30-40., 10.1016/j.tox.2011.12.015

APA

Elcombe, C. R., Elcombe, B. M., Foster, J. R., Chang, S-C., Ehresman, D. J., Noker, P. E., & Butenhoff, J. L. (2012). Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate. Toxicology, 293(1-3), 30-40. 10.1016/j.tox.2011.12.015

Vancouver

Elcombe CR, Elcombe BM, Foster JR, Chang S-C, Ehresman DJ, Noker PE et al. Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate. Toxicology. 2012 Mar 11;293(1-3):30-40. Available from: 10.1016/j.tox.2011.12.015

Author

Elcombe, Clifford R.; Elcombe, Barbara M.; Foster, John R.; Chang, Shu-Ching; Ehresman, David J.; Noker, Patricia E.; Butenhoff, John L. / Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate.

In: Toxicology, Vol. 293, No. 1-3, 11.03.2012, p. 30-40.

Research output: Contribution to journalArticle

Bibtex - Download

@article{c2030cfbb205461e9d426334a6076dfe,
title = "Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate",
author = "Elcombe, {Clifford R.} and Elcombe, {Barbara M.} and Foster, {John R.} and Shu-Ching Chang and Ehresman, {David J.} and Noker, {Patricia E.} and Butenhoff, {John L.}",
year = "2012",
doi = "10.1016/j.tox.2011.12.015",
volume = "293",
number = "1-3",
pages = "30--40",
journal = "Toxicology",
issn = "0300-483X",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate

A1 - Elcombe,Clifford R.

A1 - Elcombe,Barbara M.

A1 - Foster,John R.

A1 - Chang,Shu-Ching

A1 - Ehresman,David J.

A1 - Noker,Patricia E.

A1 - Butenhoff,John L.

AU - Elcombe,Clifford R.

AU - Elcombe,Barbara M.

AU - Foster,John R.

AU - Chang,Shu-Ching

AU - Ehresman,David J.

AU - Noker,Patricia E.

AU - Butenhoff,John L.

PY - 2012/3/11

Y1 - 2012/3/11

N2 - <p>In a prior 28-day dietary study in rats with 20 and 100 ppm K+PFOS, activation of PPAR alpha and CAR/PXR were concluded to be etiological factors in K+PFOS-induced hepatomegaly and hepatic tumorigenesis. The objective of this study was to evaluate persistence/resolution of K+PFOS-induced, liver-related effects in male Sprague Dawley rats following a 7-day dietary exposure to K+PFOS at 20 or 100 ppm. Groups of 10 rats per treatment were observed on recovery Day(s) 1, 28, 56, and 84 following treatment. Changes consistent with hepatic PPAR alpha and CAR/PXR activation noted on recovery Day 1 included: increased liver weight; decreased plasma cholesterol, alanine aminotransferase, and triglycerides; decreased liver DNA concentration and increased hepatocellular cytosolic CYP450 concentration; increased liver activity of acyl CoA oxidase, CYP4A, CYP2B. and CYP3A; increased liver proliferative index and decreased liver apoptotic index; decreased hepatocellular glycogen-induced vacuoles; increased centrilobular hepatocellular hypertrophy. Most effects resolved to control levels during recovery. Effects on plasma cholesterol, hepatocellular cytosolic CYP450 concentrations, liver apoptotic index, CYP3A, and centrilobular hepatocellular hypertrophy persisted through the end of the recovery period. Thyroid parameters (histology, apoptosis, and proliferation) were unaffected at all time points. Mean serum PFOS concentrations on recovery Day 1 were 39 and 140 mu g/mL (20 ppm and 100 ppm K+PFOS, respectively), decreasing to 4 and 26 mu g/mL by recovery Day 84. Thus, hepatic effects in male rats resulting from K+PFOS-induced activation of PPAR alpha and CAR/PXR resolved slowly or were still present after 84-days following a 7-day dietary treatment, consistent with the slow elimination rate of PFOS. (c) 2012 Elsevier Ireland Ltd. All rights reserved.</p>

AB - <p>In a prior 28-day dietary study in rats with 20 and 100 ppm K+PFOS, activation of PPAR alpha and CAR/PXR were concluded to be etiological factors in K+PFOS-induced hepatomegaly and hepatic tumorigenesis. The objective of this study was to evaluate persistence/resolution of K+PFOS-induced, liver-related effects in male Sprague Dawley rats following a 7-day dietary exposure to K+PFOS at 20 or 100 ppm. Groups of 10 rats per treatment were observed on recovery Day(s) 1, 28, 56, and 84 following treatment. Changes consistent with hepatic PPAR alpha and CAR/PXR activation noted on recovery Day 1 included: increased liver weight; decreased plasma cholesterol, alanine aminotransferase, and triglycerides; decreased liver DNA concentration and increased hepatocellular cytosolic CYP450 concentration; increased liver activity of acyl CoA oxidase, CYP4A, CYP2B. and CYP3A; increased liver proliferative index and decreased liver apoptotic index; decreased hepatocellular glycogen-induced vacuoles; increased centrilobular hepatocellular hypertrophy. Most effects resolved to control levels during recovery. Effects on plasma cholesterol, hepatocellular cytosolic CYP450 concentrations, liver apoptotic index, CYP3A, and centrilobular hepatocellular hypertrophy persisted through the end of the recovery period. Thyroid parameters (histology, apoptosis, and proliferation) were unaffected at all time points. Mean serum PFOS concentrations on recovery Day 1 were 39 and 140 mu g/mL (20 ppm and 100 ppm K+PFOS, respectively), decreasing to 4 and 26 mu g/mL by recovery Day 84. Thus, hepatic effects in male rats resulting from K+PFOS-induced activation of PPAR alpha and CAR/PXR resolved slowly or were still present after 84-days following a 7-day dietary treatment, consistent with the slow elimination rate of PFOS. (c) 2012 Elsevier Ireland Ltd. All rights reserved.</p>

U2 - 10.1016/j.tox.2011.12.015

DO - 10.1016/j.tox.2011.12.015

M1 - Article

JO - Toxicology

JF - Toxicology

SN - 0300-483X

IS - 1-3

VL - 293

SP - 30

EP - 40

ER -

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