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Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas

Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas

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Authors

  • Timothy J Burton
  • Isla S Mackenzie
  • Kottekkattu Balan
  • Brendan Koo
  • Nick Bird
  • Dmitri V Soloviev
  • Elena A B Azizan
  • Franklin Aigbirhio
  • Mark Gurnell
  • Morris J Brown

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Info

Original languageEnglish
Pages100-9
Number of pages10
JournalJournal of Clinical Endocrinology & Metabolism
Journal publication date2012
Journal number1
Volume97
DOIs
StatePublished

Abstract

Identification of unilateral aldosterone-producing (Conn's) adenomas has traditionally required lateralization by the invasive and technically difficult procedure of adrenal vein sampling (AVS). (11)C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas.

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