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Evolution of size and pattern in the social amoebas

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Evolution of size and pattern in the social amoebas. / Schaap, P.

In: BioEssays, Vol. 29, No. 7, 07.2007, p. 635-644.

Research output: Contribution to journalArticle

Harvard

Schaap, P 2007, 'Evolution of size and pattern in the social amoebas' BioEssays, vol 29, no. 7, pp. 635-644., 10.1002/bies.20599

APA

Schaap, P. (2007). Evolution of size and pattern in the social amoebas. BioEssays, 29(7), 635-644. 10.1002/bies.20599

Vancouver

Schaap P. Evolution of size and pattern in the social amoebas. BioEssays. 2007 Jul;29(7):635-644. Available from: 10.1002/bies.20599

Author

Schaap, P. / Evolution of size and pattern in the social amoebas.

In: BioEssays, Vol. 29, No. 7, 07.2007, p. 635-644.

Research output: Contribution to journalArticle

Bibtex - Download

@article{e23c88a76bca49788027158f01a0e8ff,
title = "Evolution of size and pattern in the social amoebas",
author = "P. Schaap",
year = "2007",
doi = "10.1002/bies.20599",
volume = "29",
number = "7",
pages = "635--644",
journal = "BioEssays",
issn = "0265-9247",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Evolution of size and pattern in the social amoebas

A1 - Schaap,P.

AU - Schaap,P.

PY - 2007/7

Y1 - 2007/7

N2 - A fundamental goal of biology is to understand how novel phenotypes evolved through changes in existing genes. The Dictyostelia or social amoebas represent a simple form of multicellularity, where starving cells aggregate to build fruiting structures. This review summarizes efforts to provide a framework for investigating the genetic changes that generated novel morphologies in the Dictyostelia. The foundation is a recently constructed molecular phylogeny of the Dictyostelia, which was used to examine trends in the evolution of novel forms and in the divergence of genes that shape these forms. There is a major trend towards the formation of large unbranched fruiting bodies, which is correlated with the use of cyclic AMP (cAMP) as a secreted signal to coordinate cell aggregation. The role of cAMP in aggregation arose through co-option of a pathway that originally acted to coordinate fruiting body formation. The genotypic changes that caused this innovation and the role of dynamic cAMP signaling in defining fruiting body size and pattern throughout social amoeba evolution are discussed. © 2007 Wiley Periodicals, Inc.

AB - A fundamental goal of biology is to understand how novel phenotypes evolved through changes in existing genes. The Dictyostelia or social amoebas represent a simple form of multicellularity, where starving cells aggregate to build fruiting structures. This review summarizes efforts to provide a framework for investigating the genetic changes that generated novel morphologies in the Dictyostelia. The foundation is a recently constructed molecular phylogeny of the Dictyostelia, which was used to examine trends in the evolution of novel forms and in the divergence of genes that shape these forms. There is a major trend towards the formation of large unbranched fruiting bodies, which is correlated with the use of cyclic AMP (cAMP) as a secreted signal to coordinate cell aggregation. The role of cAMP in aggregation arose through co-option of a pathway that originally acted to coordinate fruiting body formation. The genotypic changes that caused this innovation and the role of dynamic cAMP signaling in defining fruiting body size and pattern throughout social amoeba evolution are discussed. © 2007 Wiley Periodicals, Inc.

UR - http://www.scopus.com/inward/record.url?scp=34447320777&partnerID=8YFLogxK

U2 - 10.1002/bies.20599

DO - 10.1002/bies.20599

M1 - Article

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 7

VL - 29

SP - 635

EP - 644

ER -

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