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Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface

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Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface. / Paxton, Jennifer Z.; Donnelly, Kenneth; Keatch, Robert P.; Baar, Keith; Grover, Liam M.

In: Annals of Biomedical Engineering, Vol. 38, No. 6, 06.2010, p. 2155-2166.

Research output: Contribution to journalArticle

Harvard

Paxton, JZ, Donnelly, K, Keatch, RP, Baar, K & Grover, LM 2010, 'Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface' Annals of Biomedical Engineering, vol 38, no. 6, pp. 2155-2166.

APA

Paxton, J. Z., Donnelly, K., Keatch, R. P., Baar, K., & Grover, L. M. (2010). Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface. Annals of Biomedical Engineering, 38(6), 2155-2166doi: 10.1007/s10439-010-0044-0

Vancouver

Paxton JZ, Donnelly K, Keatch RP, Baar K, Grover LM. Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface. Annals of Biomedical Engineering. 2010 Jun;38(6):2155-2166.

Author

Paxton, Jennifer Z.; Donnelly, Kenneth; Keatch, Robert P.; Baar, Keith; Grover, Liam M. / Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface.

In: Annals of Biomedical Engineering, Vol. 38, No. 6, 06.2010, p. 2155-2166.

Research output: Contribution to journalArticle

Bibtex - Download

@article{4c5a8d3c501c4d488e24b167131f93c8,
title = "Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface",
author = "Paxton, {Jennifer Z.} and Kenneth Donnelly and Keatch, {Robert P.} and Keith Baar and Grover, {Liam M.}",
year = "2010",
volume = "38",
number = "6",
pages = "2155--2166",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface

A1 - Paxton,Jennifer Z.

A1 - Donnelly,Kenneth

A1 - Keatch,Robert P.

A1 - Baar,Keith

A1 - Grover,Liam M.

AU - Paxton,Jennifer Z.

AU - Donnelly,Kenneth

AU - Keatch,Robert P.

AU - Baar,Keith

AU - Grover,Liam M.

PY - 2010/6

Y1 - 2010/6

N2 - <p>The interfaces between musculoskeletal tissues with contrasting moduli are morphologically and biochemically adapted to allow the transmission of force with minimal injury. Current methods of tissue engineering ligaments and tendons do not include the interface and this may limit the future clinical success of engineered musculoskeletal tissues. This study aimed to use solid brushite cement anchors to engineer intact ligaments from bone-to-bone, creating a functional musculoskeletal interface in vitro. We show here that modifying anchor shape and cement composition can alter both the longevity and the strength of an in vitro model of the bone-ligament interface: with values reaching 23 days and 21.6 kPa, respectively. These results validate the use of brushite bone cement to engineer the bone-ligament interface in vitro and raise the potential for future use in ligament replacement surgery.</p>

AB - <p>The interfaces between musculoskeletal tissues with contrasting moduli are morphologically and biochemically adapted to allow the transmission of force with minimal injury. Current methods of tissue engineering ligaments and tendons do not include the interface and this may limit the future clinical success of engineered musculoskeletal tissues. This study aimed to use solid brushite cement anchors to engineer intact ligaments from bone-to-bone, creating a functional musculoskeletal interface in vitro. We show here that modifying anchor shape and cement composition can alter both the longevity and the strength of an in vitro model of the bone-ligament interface: with values reaching 23 days and 21.6 kPa, respectively. These results validate the use of brushite bone cement to engineer the bone-ligament interface in vitro and raise the potential for future use in ligament replacement surgery.</p>

KW - Ligament

KW - Enthesis

KW - Regenerative medicine

KW - Brushite

KW - CALCIUM-PHOSPHATE CEMENT

KW - DONOR-SITE MORBIDITY

KW - BRUSHITE CEMENT

KW - RECONSTRUCTION

KW - HYDROXYAPATITE

KW - AUTOGRAFT

KW - SCAFFOLD

KW - PYROPHOSPHATE

KW - INTEGRATION

KW - CONSTRUCTS

U2 - 10.1007/s10439-010-0044-0

DO - 10.1007/s10439-010-0044-0

M1 - Article

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - 6

VL - 38

SP - 2155

EP - 2166

ER -

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