Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface. / Paxton, Jennifer Z.; Donnelly, Kenneth; Keatch, Robert P.; Baar, Keith; Grover, Liam M.
In: Annals of Biomedical Engineering, Vol. 38, No. 6, 06.2010, p. 2155-2166.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface
A1 - Paxton,Jennifer Z.
A1 - Donnelly,Kenneth
A1 - Keatch,Robert P.
A1 - Baar,Keith
A1 - Grover,Liam M.
AU - Paxton,Jennifer Z.
AU - Donnelly,Kenneth
AU - Keatch,Robert P.
AU - Baar,Keith
AU - Grover,Liam M.
PY - 2010/6
Y1 - 2010/6
N2 - <p>The interfaces between musculoskeletal tissues with contrasting moduli are morphologically and biochemically adapted to allow the transmission of force with minimal injury. Current methods of tissue engineering ligaments and tendons do not include the interface and this may limit the future clinical success of engineered musculoskeletal tissues. This study aimed to use solid brushite cement anchors to engineer intact ligaments from bone-to-bone, creating a functional musculoskeletal interface in vitro. We show here that modifying anchor shape and cement composition can alter both the longevity and the strength of an in vitro model of the bone-ligament interface: with values reaching 23 days and 21.6 kPa, respectively. These results validate the use of brushite bone cement to engineer the bone-ligament interface in vitro and raise the potential for future use in ligament replacement surgery.</p>
AB - <p>The interfaces between musculoskeletal tissues with contrasting moduli are morphologically and biochemically adapted to allow the transmission of force with minimal injury. Current methods of tissue engineering ligaments and tendons do not include the interface and this may limit the future clinical success of engineered musculoskeletal tissues. This study aimed to use solid brushite cement anchors to engineer intact ligaments from bone-to-bone, creating a functional musculoskeletal interface in vitro. We show here that modifying anchor shape and cement composition can alter both the longevity and the strength of an in vitro model of the bone-ligament interface: with values reaching 23 days and 21.6 kPa, respectively. These results validate the use of brushite bone cement to engineer the bone-ligament interface in vitro and raise the potential for future use in ligament replacement surgery.</p>
KW - Ligament
KW - Enthesis
KW - Regenerative medicine
KW - Brushite
KW - CALCIUM-PHOSPHATE CEMENT
KW - DONOR-SITE MORBIDITY
KW - BRUSHITE CEMENT
KW - RECONSTRUCTION
KW - HYDROXYAPATITE
KW - AUTOGRAFT
KW - SCAFFOLD
KW - PYROPHOSPHATE
KW - INTEGRATION
KW - CONSTRUCTS
U2 - 10.1007/s10439-010-0044-0
DO - 10.1007/s10439-010-0044-0
M1 - Article
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
SN - 0090-6964
IS - 6
VL - 38
SP - 2155
EP - 2166
ER -