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Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

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Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex. / Munoz, Ivan M.; Macartney, Thomas; Sanchez-Pulido, Luis; Ponting, Chris P.; Rocha, Sonia; Rouse, John.

In: Journal of Biological Chemistry, Vol. 287, No. 39, 21.09.2012, p. 32346-53.

Research output: Contribution to journalArticle

Harvard

Munoz, IM, Macartney, T, Sanchez-Pulido, L, Ponting, CP, Rocha, S & Rouse, J 2012, 'Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex' Journal of Biological Chemistry, vol 287, no. 39, pp. 32346-53., 10.1074/jbc.M112.382499

APA

Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S., & Rouse, J. (2012). Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex. Journal of Biological Chemistry, 287(39), 32346-53. 10.1074/jbc.M112.382499

Vancouver

Munoz IM, Macartney T, Sanchez-Pulido L, Ponting CP, Rocha S, Rouse J. Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex. Journal of Biological Chemistry. 2012 Sep 21;287(39):32346-53. Available from: 10.1074/jbc.M112.382499

Author

Munoz, Ivan M.; Macartney, Thomas; Sanchez-Pulido, Luis; Ponting, Chris P.; Rocha, Sonia; Rouse, John / Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex.

In: Journal of Biological Chemistry, Vol. 287, No. 39, 21.09.2012, p. 32346-53.

Research output: Contribution to journalArticle

Bibtex - Download

@article{3e2cfcc428f94d3bb70ae1108620c789,
title = "Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex",
author = "Munoz, {Ivan M.} and Thomas Macartney and Luis Sanchez-Pulido and Ponting, {Chris P.} and Sonia Rocha and John Rouse",
year = "2012",
doi = "10.1074/jbc.M112.382499",
volume = "287",
number = "39",
pages = "32346--53",
journal = "Journal of Biological Chemistry",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

A1 - Munoz,Ivan M.

A1 - Macartney,Thomas

A1 - Sanchez-Pulido,Luis

A1 - Ponting,Chris P.

A1 - Rocha,Sonia

A1 - Rouse,John

AU - Munoz,Ivan M.

AU - Macartney,Thomas

AU - Sanchez-Pulido,Luis

AU - Ponting,Chris P.

AU - Rocha,Sonia

AU - Rouse,John

PY - 2012/9/21

Y1 - 2012/9/21

N2 - The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcription. Here we describe family with sequence similarity 60A (FAM60A), a cell cycle-regulated protein that binds to the SIN3-HDAC complex. FAM60A expression peaks during G(1) and S phases of the cell cycle in U2OS cells, in a manner similar to the G(1) regulator cyclin D1, which is a known target of SIN3-HDAC. In this light we found that FAM60A binds to SIN3-HDAC-regulated promoters such as cyclin D1 in G(1) and S phases. Cells depleted of FAM60A show increased histone acetylation at the cyclin D1 promoter and elevated levels of cyclin D1 mRNA and protein. Furthermore, depletion of FAM60A altered the periodic association of HDAC1 with the cyclin D1 promoter, increased cyclin D1 expression at all cell cycle phases, and caused premature S phase entry. The data in this study introduce FAM60A as a novel regulator of SIN3-HDAC function and gene expression.

AB - The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcription. Here we describe family with sequence similarity 60A (FAM60A), a cell cycle-regulated protein that binds to the SIN3-HDAC complex. FAM60A expression peaks during G(1) and S phases of the cell cycle in U2OS cells, in a manner similar to the G(1) regulator cyclin D1, which is a known target of SIN3-HDAC. In this light we found that FAM60A binds to SIN3-HDAC-regulated promoters such as cyclin D1 in G(1) and S phases. Cells depleted of FAM60A show increased histone acetylation at the cyclin D1 promoter and elevated levels of cyclin D1 mRNA and protein. Furthermore, depletion of FAM60A altered the periodic association of HDAC1 with the cyclin D1 promoter, increased cyclin D1 expression at all cell cycle phases, and caused premature S phase entry. The data in this study introduce FAM60A as a novel regulator of SIN3-HDAC function and gene expression.

U2 - 10.1074/jbc.M112.382499

DO - 10.1074/jbc.M112.382499

M1 - Article

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 39

VL - 287

SP - 32346

EP - 32353

ER -

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