Discovery - University of Dundee - Online Publications

Library & Learning Centre

From cannabis to the endocannabinoid system

Standard

From cannabis to the endocannabinoid system : refocussing attention on potential clinical benefits. / Youssef, F.F.; Irving, A.J.

In: West Indian Medical Journal, Vol. 61, No. 3, 2012.

Research output: Contribution to journalArticle

Harvard

Youssef, FF & Irving, AJ 2012, 'From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits' West Indian Medical Journal, vol 61, no. 3.

APA

Youssef, F. F., & Irving, A. J. (2012). From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits. West Indian Medical Journal, 61(3).

Vancouver

Youssef FF, Irving AJ. From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits. West Indian Medical Journal. 2012;61(3).

Author

Youssef, F.F.; Irving, A.J. / From cannabis to the endocannabinoid system : refocussing attention on potential clinical benefits.

In: West Indian Medical Journal, Vol. 61, No. 3, 2012.

Research output: Contribution to journalArticle

Bibtex - Download

@article{69a23391900b4465891c7773f5484728,
title = "From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits",
author = "F.F. Youssef and A.J. Irving",
year = "2012",
volume = "61",
number = "3",
journal = "West Indian Medical Journal",
issn = "0043-3144",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - From cannabis to the endocannabinoid system

T2 - refocussing attention on potential clinical benefits

A1 - Youssef,F.F.

A1 - Irving,A.J.

AU - Youssef,F.F.

AU - Irving,A.J.

PY - 2012

Y1 - 2012

N2 - Cannabis sativa is one of the oldest herbal remedies known to man. Over the past four thousand years, it has been used for the treatment of numerous diseases but due to its psychoactive properties its current medicinal usage is highly restricted. In this review, we seek to highlight advances made over the last forty years in the understanding of the mechanisms responsible for the effects of cannabis on the human body and how these can potentially be utilized in clinical practice. During this time, the primary active ingredients in cannabis have been isolated, specific cannabinoid receptors have been discovered and at least five endogenous cannabinoid neurotransmitters (endocannabinoids) have been identified. Together, these form the framework of a complex endocannabinoid signalling system that has widespread distribution in the body and plays a role in regulating numerous physiological processes within the body. Cannabinoid ligands are therefore thought to display considerable therapeutic potential and the drive to develop compounds that can be targeted to specific neuronal systems at low enough doses so as to eliminate cognitive side effects remains the 'holy grail' of endocannabinoid research.

AB - Cannabis sativa is one of the oldest herbal remedies known to man. Over the past four thousand years, it has been used for the treatment of numerous diseases but due to its psychoactive properties its current medicinal usage is highly restricted. In this review, we seek to highlight advances made over the last forty years in the understanding of the mechanisms responsible for the effects of cannabis on the human body and how these can potentially be utilized in clinical practice. During this time, the primary active ingredients in cannabis have been isolated, specific cannabinoid receptors have been discovered and at least five endogenous cannabinoid neurotransmitters (endocannabinoids) have been identified. Together, these form the framework of a complex endocannabinoid signalling system that has widespread distribution in the body and plays a role in regulating numerous physiological processes within the body. Cannabinoid ligands are therefore thought to display considerable therapeutic potential and the drive to develop compounds that can be targeted to specific neuronal systems at low enough doses so as to eliminate cognitive side effects remains the 'holy grail' of endocannabinoid research.

UR - http://www.scopus.com/inward/record.url?scp=84866000242&partnerID=8YFLogxK

M1 - Article

JO - West Indian Medical Journal

JF - West Indian Medical Journal

SN - 0043-3144

IS - 3

VL - 61

ER -

Library & Learning Centre

Contact | Accessibility | Policy