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Genetic loci influencing kidney function and chronic kidney disease

Genetic loci influencing kidney function and chronic kidney disease

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Authors

  • John C. Chambers
  • Weihua Zhang
  • Graham M. Lord
  • Pim van der Harst
  • Debbie A. Lawlor
  • Joban S. Sehmi
  • Daniel P. Gale
  • Mark N. Wass
  • Kourosh R. Ahmadi
  • Stephan J. L. Bakker
  • Jacqui Beckmann
  • Henk J. G. Bilo
  • Murielle Bochud
  • Morris J. Brown
  • Mark J. Caulfield
  • John M. C. Connell
  • H. Terence Cook
  • Ioana Cotlarciuc
  • George Davey Smith
  • Ranil de Silva
  • And 74 others
  • Guohong Deng
  • Olivier Devuyst
  • Lambert D. Dikkeschei
  • Nada Dimkovic
  • Mark Dockrell
  • Anna Dominiczak
  • Shah Ebrahim
  • Thomas Eggermann
  • Martin Farrall
  • Luigi Ferrucci
  • Jurgen Floege
  • Nita G. Forouhi
  • Ron T. Gansevoort
  • Xijin Han
  • Bo Hedblad
  • Jaap J. Homan van der Heide
  • Bouke G. Hepkema
  • Maria Hernandez-Fuentes
  • Elina Hypponen
  • Toby Johnson
  • Paul E. de Jong
  • Nanne Kleefstra
  • Vasiliki Lagou
  • Marta Lapsley
  • Yun Li
  • Ruth J. F. Loos
  • Jian'an Luan
  • Karin Luttropp
  • Celine Marechal
  • Olle Melander
  • Patricia B. Munroe
  • Louise Nordfors
  • Afshin Parsa
  • Leena Peltonen
  • Brenda W. Penninx
  • Esperanza Perucha
  • Anneli Pouta
  • Inga Prokopenko
  • Paul J. Roderick
  • Aimo Ruokonen
  • Nilesh J. Samani
  • Serena Sanna
  • Martin Schalling
  • David Schlessinger
  • Georg Schlieper
  • Marc A. J. Seelen
  • Alan R. Shuldiner
  • Marketa Sjogren
  • Johannes H. Smit
  • Harold Snieder
  • Nicole Soranzo
  • Timothy D. Spector
  • Peter Stenvinkel
  • Michael J. E. Sternberg
  • Ramasamyiyer Swaminathan
  • Toshiko Tanaka
  • Lielith J. Ubink-Veltmaat
  • Manuela Uda
  • Peter Vollenweider
  • Chris Wallace
  • Dawn Waterworth
  • Klaus Zerres
  • Gerard Waeber
  • Nicholas J. Wareham
  • Patrick H. Maxwell
  • Mark I. McCarthy
  • Marjo-Riitta Jarvelin
  • Vincent Mooser
  • Goncalo R. Abecasis
  • Liz Lightstone
  • James Scott
  • Gerjan Navis
  • Paul Elliott
  • Jaspal S. Kooner

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Info

Original languageEnglish
Pages373-375
Number of pages3
JournalNature Genetics
Journal publication dateMay 2010
Journal number5
Volume42
DOIs
StatePublished

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

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