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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. / Ehret, Georg B.; Munroe, Patricia B.; Rice, Kenneth M.; Bochud, Murielle; Johnson, Andrew D.; Chasman, Daniel I.; Smith, Albert V.; Tobin, Martin D.; Verwoert, Germaine C.; Hwang, Shih-Jen; Pihur, Vasyl; Vollenweider, Peter; O'Reilly, Paul F.; Amin, Najaf; Bragg-Gresham, Jennifer L.; Teumer, Alexander; Glazer, Nicole L.; Launer, Lenore; Zhao, Jing Hua; Aulchenko, Yurii; Heath, Simon; Sober, Siim; Parsa, Afshin; Luan, Jian'an; Arora, Pankaj; Dehghan, Abbas; Zhang, Feng; Lucas, Gavin; Hicks, Andrew A.; Jackson, Anne U.; Peden, John F.; Tanaka, Toshiko; Wild, Sarah H.; Rudan, Igor; Igl, Wilmar; Milaneschi, Yuri; Parker, Alex N.; Fava, Cristiano; Chambers, John C.; Fox, Ervin R.; Kumari, Meena; Go, Min Jin; van der Harst, Pim; Kao, Wen Hong Linda; Sjogren, Marketa; Vinay, D. G.; Alexander, Myriam; Tabara, Yasuharu; Shaw-Hawkins, Sue; Whincup, Peter H.; Liu, Yongmei; Shi, Gang; Kuusisto, Johanna; Tayo, Bamidele; Seielstad, Mark; Sim, Xueling; Khanh-Dung Hoang Nguyen, [No Value]; Lehtimaki, Terho; Matullo, Giuseppe; Wu, Ying; Gaunt, Tom R.; Onland-Moret, N. Charlotte; Cooper, Matthew N.; Platou, Carl G. P.; Org, Elin; Hardy, Rebecca; Dahgam, Santosh; Palmen, Jutta; Vitart, Veronique; Braund, Peter S.; Kuznetsova, Tatiana; Uiterwaal, Cuno S. P. M.; Adeyemo, Adebowale; Palmas, Walter; Campbell, Harry; Ludwig, Barbara; Tomaszewski, Maciej; Tzoulaki, Ioanna; Palmer, Nicholette D.; Aspelund, Thor; Garcia, Melissa; Chang, Yen-Pei C.; O'Connell, Jeffrey R.; Steinle, Nanette I.; Grobbee, Diederick E.; Arking, Dan E.; Kardia, Sharon L.; Morrison, Alanna C.; Hernandez, Dena; Najjar, Samer; McArdle, Wendy L.; Hadley, David; Brown, Morris J.; Connell, John M.; Hingorani, Aroon D.; Day, Ian N. M.; Lawlor, Debbie A.; Beilby, John P.; Lawrence, Robert W.; Clarke, Robert; Hopewell, Jemma C.; Ongen, Halit; Dreisbach, Albert W.; Li, Yali; Young, J. Hunter; Bis, Joshua C.; Kahonen, Mika; Viikari, Jorma; Adair, Linda S.; Lee, Nanette R.; Chen, Ming-Huei; Olden, Matthias; Pattaro, Cristian; Bolton, Judith A. Hoffman; Köttgen, Anna; Bergmann, Sven; Mooser, Vincent; Chaturvedi, Nish; Frayling, Timothy M.; Islam, Muhammad; Jafar, Tazeen H.; Erdmann, Jeanette; Kulkarni, Smita R.; Bornstein, Stefan R.; Graessler, Juergen; Groop, Leif; Voight, Benjamin F.; Kettunen, Johannes; Howard, Philip; Taylor, Andrew; Guarrera, Simonetta; Ricceri, Fulvio; Emilsson, Valur; Plump, Andrew; Barroso, Ine S.; Khaw, Kay-Tee; Weder, Alan B.; Hunt, Steven C.; Sun, Yan V.; Bergman, Richard N.; Collins, Francis S.; Bonnycastle, Lori L.; Scott, Laura J.; Stringham, Heather M.; Peltonen, Leena; Perola, Markus; Vartiainen, Erkki; Brand, Stefan-Martin; Staessen, Jan A.; Wang, Thomas J.; Burton, Paul R.; Artigas, Maria Soler; Dong, Yanbin; Snieder, Harold; Wang, Xiaoling; Zhu, Haidong; Lohman, Kurt K.; Rudock, Megan E.; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Doumatey, Ayo; Shriner, Daniel; Veldre, Gudrun; Viigimaa, Margus; Kinra, Sanjay; Prabhakaran, Dorairaj; Tripathy, Vikal; Langefeld, Carl D.; Rosengren, Annika; Thelle, Dag S.; Corsi, Anna Maria; Singleton, Andrew; Forrester, Terrence; Hilton, Gina; McKenzie, Colin A.; Salako, Tunde; Iwai, Naoharu; Kita, Yoshikuni; Ogihara, Toshio; Ohkubo, Takayoshi; Okamura, Tomonori; Ueshima, Hirotsugu; Umemura, Satoshi; Eyheramendy, Susana; Meitinger, Thomas; Wichmann, H. -Erich; Cho, Yoon Shin; Kim, Hyung-Lae; Lee, Jong-Young; Scott, James; Sehmi, Joban S.; Zhang, Weihua; Hedblad, Bo; Nilsson, Peter; Smith, George Davey; Wong, Andrew; Narisu, Narisu; Stancakova, Alena; Raffel, Leslie J.; Yao, Jie; Kathiresan, Sekar; O'Donnell, Christopher J.; Schwartz, Stephen M.; Ikram, M. Arfan; Longstreth, W. T.; Mosley, Thomas H.; Seshadri, Sudha; Shrine, Nick R. G.; Wain, Louise V.; Morken, Mario A.; Swift, Amy J.; Laitinen, Jaana; Prokopenko, Inga; Zitting, Paavo; Cooper, Jackie A.; Humphries, Steve E.; Danesh, John; Rasheed, Asif; Goel, Anuj; Hamsten, Anders; Watkins, Hugh; Bakker, Stephan J. L.; van Gilst, Wiek H.; Janipalli, Charles S.; Mani, K. Radha; Yajnik, Chittaranjan S.; Hofman, Albert; Mattace-Raso, Francesco U. S.; Oostra, Ben A.; Demirkan, Ayse; Isaacs, Aaron; Rivadeneira, Fernando; Lakatta, Edward G.; Orru, Marco; Scuteri, Angelo; Ala-Korpela, Mika; Kangas, Antti J.; Lyytikainen, Leo-Pekka; Soininen, Pasi; Tukiainen, Taru; Wurtz, Peter; Ong, Rick Twee-Hee; Doerr, Marcus; Kroemer, Heyo K.; Voelker, Uwe; Voelzke, Henry; Galan, Pilar; Hercberg, Serge; Lathrop, Mark; Zelenika, Diana; Deloukas, Panos; Mangino, Massimo; Spector, Tim D.; Zhai, Guangju; Meschia, James F.; Nalls, Michael A.; Sharma, Pankaj; Terzic, Janos; Kumar, M. V. Kranthi; Denniff, Matthew; Zukowska-Szczechowska, Ewa; Wagenknecht, Lynne E.; Fowkes, F. Gerald R.; Charchar, Fadi J.; Schwarz, Peter E. H.; Hayward, Caroline; Guo, Xiuqing; Rotimi, Charles; Bots, Michiel L.; Brand, Eva; Samani, Nilesh J.; Polasek, Ozren; Talmud, Philippa J.; Nyberg, Fredrik; Kuh, Diana; Laan, Maris; Hveem, Kristian; Palmer, Lyle J.; van der Schouw, Yvonne T.; Casas, Juan P.; Mohlke, Karen L.; Vineis, Paolo; Raitakari, Olli; Ganesh, Santhi K.; Wong, Tien Y.; Tai, E. Shyong; Cooper, Richard S.; Laakso, Markku; Rao, Dabeeru C.; Harris, Tamara B.; Morris, Richard W.; Dominiczak, Anna F.; Kivimaki, Mika; Marmot, Michael G.; Miki, Tetsuro; Saleheen, Danish; Chandak, Giriraj R.; Coresh, Josef; Navis, Gerjan; Salomaa, Veikko; Han, Bok-Ghee; Zhu, Xiaofeng; Kooner, Jaspal S.; Melander, Olle; Ridker, Paul M.; Bandinelli, Stefania; Gyllensten, Ulf B.; Wright, Alan F.; Wilson, James F.; Ferrucci, Luigi; Farrall, Martin; Tuomilehto, Jaakko; Pramstaller, Peter P.; Elosua, Roberto; Soranzo, Nicole; Sijbrands, Eric J. G.; Altshuler, David; Loos, Ruth J. F.; Shuldiner, Alan R.; Gieger, Christian; Meneton, Pierre; Uitterlinden, Andre G.; Wareham, Nicholas J.; Gudnason, Vilmundur; Rotter, Jerome I.; Rettig, Rainer; Uda, Manuela; Strachan, David P.; Witteman, Jacqueline C. M.; Hartikainen, Anna-Liisa; Beckmann, Jacques S.; Boerwinkle, Eric; Vasan, Ramachandran S.; Boehnke, Michael; Larson, Martin G.; Jarvelin, Marjo-Riitta; Psaty, Bruce M.; Abecasis, Goncalo R.; Chakravarti, Aravinda; Elliott, Paul; van Duijn, Cornelia M.; Newton-Cheh, Christopher; Levy, Daniel; Caulfield, Mark J.; Johnson, Toby; CARDIoGRAM Consortium, KidneyGen Consortium, EchoGen Consortium, CKDGen Consortium, Int Consortium Blood Pressure Geno, CHARGE-HF Consortium.

In: Nature, Vol. 478, No. 7367, 06.10.2011, p. 103-109.

Research output: Contribution to journalArticle

Harvard

Ehret, GB, Munroe, PB, Rice, KM, Bochud, M, Johnson, AD, Chasman, DI, Smith, AV, Tobin, MD, Verwoert, GC, Hwang, S-J, Pihur, V, Vollenweider, P, O'Reilly, PF, Amin, N, Bragg-Gresham, JL, Teumer, A, Glazer, NL, Launer, L, Zhao, JH, Aulchenko, Y, Heath, S, Sober, S, Parsa, A, Luan, J, Arora, P, Dehghan, A, Zhang, F, Lucas, G, Hicks, AA, Jackson, AU, Peden, JF, Tanaka, T, Wild, SH, Rudan, I, Igl, W, Milaneschi, Y, Parker, AN, Fava, C, Chambers, JC, Fox, ER, Kumari, M, Go, MJ, van der Harst, P, Kao, WHL, Sjogren, M, Vinay, DG, Alexander, M, Tabara, Y, Shaw-Hawkins, S, Whincup, PH, Liu, Y, Shi, G, Kuusisto, J, Tayo, B, Seielstad, M, Sim, X, Khanh-Dung Hoang Nguyen, NV, Lehtimaki, T, Matullo, G, Wu, Y, Gaunt, TR, Onland-Moret, NC, Cooper, MN, Platou, CGP, Org, E, Hardy, R, Dahgam, S, Palmen, J, Vitart, V, Braund, PS, Kuznetsova, T, Uiterwaal, CSPM, Adeyemo, A, Palmas, W, Campbell, H, Ludwig, B, Tomaszewski, M, Tzoulaki, I, Palmer, ND, Aspelund, T, Garcia, M, Chang, Y-PC, O'Connell, JR, Steinle, NI, Grobbee, DE, Arking, DE, Kardia, SL, Morrison, AC, Hernandez, D, Najjar, S, McArdle, WL, Hadley, D, Brown, MJ, Connell, JM, Hingorani, AD, Day, INM, Lawlor, DA, Beilby, JP, Lawrence, RW, Clarke, R, Hopewell, JC, Ongen, H, Dreisbach, AW, Li, Y, Young, JH, Bis, JC, Kahonen, M, Viikari, J, Adair, LS, Lee, NR, Chen, M-H, Olden, M, Pattaro, C, Bolton, JAH, Köttgen, A, Bergmann, S, Mooser, V, Chaturvedi, N, Frayling, TM, Islam, M, Jafar, TH, Erdmann, J, Kulkarni, SR, Bornstein, SR, Graessler, J, Groop, L, Voight, BF, Kettunen, J, Howard, P, Taylor, A, Guarrera, S, Ricceri, F, Emilsson, V, Plump, A, Barroso, IS, Khaw, K-T, Weder, AB, Hunt, SC, Sun, YV, Bergman, RN, Collins, FS, Bonnycastle, LL, Scott, LJ, Stringham, HM, Peltonen, L, Perola, M, Vartiainen, E, Brand, S-M, Staessen, JA, Wang, TJ, Burton, PR, Artigas, MS, Dong, Y, Snieder, H, Wang, X, Zhu, H, Lohman, KK, Rudock, ME, Heckbert, SR, Smith, NL, Wiggins, KL, Doumatey, A, Shriner, D, Veldre, G, Viigimaa, M, Kinra, S, Prabhakaran, D, Tripathy, V, Langefeld, CD, Rosengren, A, Thelle, DS, Corsi, AM, Singleton, A, Forrester, T, Hilton, G, McKenzie, CA, Salako, T, Iwai, N, Kita, Y, Ogihara, T, Ohkubo, T, Okamura, T, Ueshima, H, Umemura, S, Eyheramendy, S, Meitinger, T, Wichmann, H-E, Cho, YS, Kim, H-L, Lee, J-Y, Scott, J, Sehmi, JS, Zhang, W, Hedblad, B, Nilsson, P, Smith, GD, Wong, A, Narisu, N, Stancakova, A, Raffel, LJ, Yao, J, Kathiresan, S, O'Donnell, CJ, Schwartz, SM, Ikram, MA, Longstreth, WT, Mosley, TH, Seshadri, S, Shrine, NRG, Wain, LV, Morken, MA, Swift, AJ, Laitinen, J, Prokopenko, I, Zitting, P, Cooper, JA, Humphries, SE, Danesh, J, Rasheed, A, Goel, A, Hamsten, A, Watkins, H, Bakker, SJL, van Gilst, WH, Janipalli, CS, Mani, KR, Yajnik, CS, Hofman, A, Mattace-Raso, FUS, Oostra, BA, Demirkan, A, Isaacs, A, Rivadeneira, F, Lakatta, EG, Orru, M, Scuteri, A, Ala-Korpela, M, Kangas, AJ, Lyytikainen, L-P, Soininen, P, Tukiainen, T, Wurtz, P, Ong, RT-H, Doerr, M, Kroemer, HK, Voelker, U, Voelzke, H, Galan, P, Hercberg, S, Lathrop, M, Zelenika, D, Deloukas, P, Mangino, M, Spector, TD, Zhai, G, Meschia, JF, Nalls, MA, Sharma, P, Terzic, J, Kumar, MVK, Denniff, M, Zukowska-Szczechowska, E, Wagenknecht, LE, Fowkes, FGR, Charchar, FJ, Schwarz, PEH, Hayward, C, Guo, X, Rotimi, C, Bots, ML, Brand, E, Samani, NJ, Polasek, O, Talmud, PJ, Nyberg, F, Kuh, D, Laan, M, Hveem, K, Palmer, LJ, van der Schouw, YT, Casas, JP, Mohlke, KL, Vineis, P, Raitakari, O, Ganesh, SK, Wong, TY, Tai, ES, Cooper, RS, Laakso, M, Rao, DC, Harris, TB, Morris, RW, Dominiczak, AF, Kivimaki, M, Marmot, MG, Miki, T, Saleheen, D, Chandak, GR, Coresh, J, Navis, G, Salomaa, V, Han, B-G, Zhu, X, Kooner, JS, Melander, O, Ridker, PM, Bandinelli, S, Gyllensten, UB, Wright, AF, Wilson, JF, Ferrucci, L, Farrall, M, Tuomilehto, J, Pramstaller, PP, Elosua, R, Soranzo, N, Sijbrands, EJG, Altshuler, D, Loos, RJF, Shuldiner, AR, Gieger, C, Meneton, P, Uitterlinden, AG, Wareham, NJ, Gudnason, V, Rotter, JI, Rettig, R, Uda, M, Strachan, DP, Witteman, JCM, Hartikainen, A-L, Beckmann, JS, Boerwinkle, E, Vasan, RS, Boehnke, M, Larson, MG, Jarvelin, M-R, Psaty, BM, Abecasis, GR, Chakravarti, A, Elliott, P, van Duijn, CM, Newton-Cheh, C, Levy, D, Caulfield, MJ, Johnson, T & CARDIoGRAM Consortium, KidneyGen Consortium, EchoGen Consortium, CKDGen Consortium, Int Consortium Blood Pressure Geno, CHARGE-HF Consortium 2011, 'Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk' Nature, vol 478, no. 7367, pp. 103-109., 10.1038/nature10405

APA

Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., ... CARDIoGRAM Consortium, KidneyGen Consortium, EchoGen Consortium, CKDGen Consortium, Int Consortium Blood Pressure Geno, CHARGE-HF Consortium (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), 103-109. 10.1038/nature10405

Vancouver

Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Oct 6;478(7367):103-109. Available from: 10.1038/nature10405

Author

Ehret, Georg B.; Munroe, Patricia B.; Rice, Kenneth M.; Bochud, Murielle; Johnson, Andrew D.; Chasman, Daniel I.; Smith, Albert V.; Tobin, Martin D.; Verwoert, Germaine C.; Hwang, Shih-Jen; Pihur, Vasyl; Vollenweider, Peter; O'Reilly, Paul F.; Amin, Najaf; Bragg-Gresham, Jennifer L.; Teumer, Alexander; Glazer, Nicole L.; Launer, Lenore; Zhao, Jing Hua; Aulchenko, Yurii; Heath, Simon; Sober, Siim; Parsa, Afshin; Luan, Jian'an; Arora, Pankaj; Dehghan, Abbas; Zhang, Feng; Lucas, Gavin; Hicks, Andrew A.; Jackson, Anne U.; Peden, John F.; Tanaka, Toshiko; Wild, Sarah H.; Rudan, Igor; Igl, Wilmar; Milaneschi, Yuri; Parker, Alex N.; Fava, Cristiano; Chambers, John C.; Fox, Ervin R.; Kumari, Meena; Go, Min Jin; van der Harst, Pim; Kao, Wen Hong Linda; Sjogren, Marketa; Vinay, D. G.; Alexander, Myriam; Tabara, Yasuharu; Shaw-Hawkins, Sue; Whincup, Peter H.; Liu, Yongmei; Shi, Gang; Kuusisto, Johanna; Tayo, Bamidele; Seielstad, Mark; Sim, Xueling; Khanh-Dung Hoang Nguyen, [No Value]; Lehtimaki, Terho; Matullo, Giuseppe; Wu, Ying; Gaunt, Tom R.; Onland-Moret, N. Charlotte; Cooper, Matthew N.; Platou, Carl G. P.; Org, Elin; Hardy, Rebecca; Dahgam, Santosh; Palmen, Jutta; Vitart, Veronique; Braund, Peter S.; Kuznetsova, Tatiana; Uiterwaal, Cuno S. P. M.; Adeyemo, Adebowale; Palmas, Walter; Campbell, Harry; Ludwig, Barbara; Tomaszewski, Maciej; Tzoulaki, Ioanna; Palmer, Nicholette D.; Aspelund, Thor; Garcia, Melissa; Chang, Yen-Pei C.; O'Connell, Jeffrey R.; Steinle, Nanette I.; Grobbee, Diederick E.; Arking, Dan E.; Kardia, Sharon L.; Morrison, Alanna C.; Hernandez, Dena; Najjar, Samer; McArdle, Wendy L.; Hadley, David; Brown, Morris J.; Connell, John M.; Hingorani, Aroon D.; Day, Ian N. M.; Lawlor, Debbie A.; Beilby, John P.; Lawrence, Robert W.; Clarke, Robert; Hopewell, Jemma C.; Ongen, Halit; Dreisbach, Albert W.; Li, Yali; Young, J. Hunter; Bis, Joshua C.; Kahonen, Mika; Viikari, Jorma; Adair, Linda S.; Lee, Nanette R.; Chen, Ming-Huei; Olden, Matthias; Pattaro, Cristian; Bolton, Judith A. Hoffman; Köttgen, Anna; Bergmann, Sven; Mooser, Vincent; Chaturvedi, Nish; Frayling, Timothy M.; Islam, Muhammad; Jafar, Tazeen H.; Erdmann, Jeanette; Kulkarni, Smita R.; Bornstein, Stefan R.; Graessler, Juergen; Groop, Leif; Voight, Benjamin F.; Kettunen, Johannes; Howard, Philip; Taylor, Andrew; Guarrera, Simonetta; Ricceri, Fulvio; Emilsson, Valur; Plump, Andrew; Barroso, Ine S.; Khaw, Kay-Tee; Weder, Alan B.; Hunt, Steven C.; Sun, Yan V.; Bergman, Richard N.; Collins, Francis S.; Bonnycastle, Lori L.; Scott, Laura J.; Stringham, Heather M.; Peltonen, Leena; Perola, Markus; Vartiainen, Erkki; Brand, Stefan-Martin; Staessen, Jan A.; Wang, Thomas J.; Burton, Paul R.; Artigas, Maria Soler; Dong, Yanbin; Snieder, Harold; Wang, Xiaoling; Zhu, Haidong; Lohman, Kurt K.; Rudock, Megan E.; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Doumatey, Ayo; Shriner, Daniel; Veldre, Gudrun; Viigimaa, Margus; Kinra, Sanjay; Prabhakaran, Dorairaj; Tripathy, Vikal; Langefeld, Carl D.; Rosengren, Annika; Thelle, Dag S.; Corsi, Anna Maria; Singleton, Andrew; Forrester, Terrence; Hilton, Gina; McKenzie, Colin A.; Salako, Tunde; Iwai, Naoharu; Kita, Yoshikuni; Ogihara, Toshio; Ohkubo, Takayoshi; Okamura, Tomonori; Ueshima, Hirotsugu; Umemura, Satoshi; Eyheramendy, Susana; Meitinger, Thomas; Wichmann, H. -Erich; Cho, Yoon Shin; Kim, Hyung-Lae; Lee, Jong-Young; Scott, James; Sehmi, Joban S.; Zhang, Weihua; Hedblad, Bo; Nilsson, Peter; Smith, George Davey; Wong, Andrew; Narisu, Narisu; Stancakova, Alena; Raffel, Leslie J.; Yao, Jie; Kathiresan, Sekar; O'Donnell, Christopher J.; Schwartz, Stephen M.; Ikram, M. Arfan; Longstreth, W. T.; Mosley, Thomas H.; Seshadri, Sudha; Shrine, Nick R. G.; Wain, Louise V.; Morken, Mario A.; Swift, Amy J.; Laitinen, Jaana; Prokopenko, Inga; Zitting, Paavo; Cooper, Jackie A.; Humphries, Steve E.; Danesh, John; Rasheed, Asif; Goel, Anuj; Hamsten, Anders; Watkins, Hugh; Bakker, Stephan J. L.; van Gilst, Wiek H.; Janipalli, Charles S.; Mani, K. Radha; Yajnik, Chittaranjan S.; Hofman, Albert; Mattace-Raso, Francesco U. S.; Oostra, Ben A.; Demirkan, Ayse; Isaacs, Aaron; Rivadeneira, Fernando; Lakatta, Edward G.; Orru, Marco; Scuteri, Angelo; Ala-Korpela, Mika; Kangas, Antti J.; Lyytikainen, Leo-Pekka; Soininen, Pasi; Tukiainen, Taru; Wurtz, Peter; Ong, Rick Twee-Hee; Doerr, Marcus; Kroemer, Heyo K.; Voelker, Uwe; Voelzke, Henry; Galan, Pilar; Hercberg, Serge; Lathrop, Mark; Zelenika, Diana; Deloukas, Panos; Mangino, Massimo; Spector, Tim D.; Zhai, Guangju; Meschia, James F.; Nalls, Michael A.; Sharma, Pankaj; Terzic, Janos; Kumar, M. V. Kranthi; Denniff, Matthew; Zukowska-Szczechowska, Ewa; Wagenknecht, Lynne E.; Fowkes, F. Gerald R.; Charchar, Fadi J.; Schwarz, Peter E. H.; Hayward, Caroline; Guo, Xiuqing; Rotimi, Charles; Bots, Michiel L.; Brand, Eva; Samani, Nilesh J.; Polasek, Ozren; Talmud, Philippa J.; Nyberg, Fredrik; Kuh, Diana; Laan, Maris; Hveem, Kristian; Palmer, Lyle J.; van der Schouw, Yvonne T.; Casas, Juan P.; Mohlke, Karen L.; Vineis, Paolo; Raitakari, Olli; Ganesh, Santhi K.; Wong, Tien Y.; Tai, E. Shyong; Cooper, Richard S.; Laakso, Markku; Rao, Dabeeru C.; Harris, Tamara B.; Morris, Richard W.; Dominiczak, Anna F.; Kivimaki, Mika; Marmot, Michael G.; Miki, Tetsuro; Saleheen, Danish; Chandak, Giriraj R.; Coresh, Josef; Navis, Gerjan; Salomaa, Veikko; Han, Bok-Ghee; Zhu, Xiaofeng; Kooner, Jaspal S.; Melander, Olle; Ridker, Paul M.; Bandinelli, Stefania; Gyllensten, Ulf B.; Wright, Alan F.; Wilson, James F.; Ferrucci, Luigi; Farrall, Martin; Tuomilehto, Jaakko; Pramstaller, Peter P.; Elosua, Roberto; Soranzo, Nicole; Sijbrands, Eric J. G.; Altshuler, David; Loos, Ruth J. F.; Shuldiner, Alan R.; Gieger, Christian; Meneton, Pierre; Uitterlinden, Andre G.; Wareham, Nicholas J.; Gudnason, Vilmundur; Rotter, Jerome I.; Rettig, Rainer; Uda, Manuela; Strachan, David P.; Witteman, Jacqueline C. M.; Hartikainen, Anna-Liisa; Beckmann, Jacques S.; Boerwinkle, Eric; Vasan, Ramachandran S.; Boehnke, Michael; Larson, Martin G.; Jarvelin, Marjo-Riitta; Psaty, Bruce M.; Abecasis, Goncalo R.; Chakravarti, Aravinda; Elliott, Paul; van Duijn, Cornelia M.; Newton-Cheh, Christopher; Levy, Daniel; Caulfield, Mark J.; Johnson, Toby; CARDIoGRAM Consortium, KidneyGen Consortium, EchoGen Consortium, CKDGen Consortium, Int Consortium Blood Pressure Geno, CHARGE-HF Consortium / Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

In: Nature, Vol. 478, No. 7367, 06.10.2011, p. 103-109.

Research output: Contribution to journalArticle

Bibtex - Download

@article{3b2377c47ebe4c2387aa8f667ed4455b,
title = "Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk",
keywords = "GENOME-WIDE ASSOCIATION, COMMON VARIANTS, HYPERTENSION, METAANALYSIS, LOCI, POPULATION, RELEVANCE, RECEPTOR, CLONING, HEALTH",
author = "Ehret, {Georg B.} and Munroe, {Patricia B.} and Rice, {Kenneth M.} and Murielle Bochud and Johnson, {Andrew D.} and Chasman, {Daniel I.} and Smith, {Albert V.} and Tobin, {Martin D.} and Verwoert, {Germaine C.} and Shih-Jen Hwang and Vasyl Pihur and Peter Vollenweider and O'Reilly, {Paul F.} and Najaf Amin and Bragg-Gresham, {Jennifer L.} and Alexander Teumer and Glazer, {Nicole L.} and Lenore Launer and Zhao, {Jing Hua} and Yurii Aulchenko and Simon Heath and Siim Sober and Afshin Parsa and Jian'an Luan and Pankaj Arora and Abbas Dehghan and Feng Zhang and Gavin Lucas and Hicks, {Andrew A.} and Jackson, {Anne U.} and Peden, {John F.} and Toshiko Tanaka and Wild, {Sarah H.} and Igor Rudan and Wilmar Igl and Yuri Milaneschi and Parker, {Alex N.} and Cristiano Fava and Chambers, {John C.} and Fox, {Ervin R.} and Meena Kumari and Go, {Min Jin} and {van der Harst}, Pim and Kao, {Wen Hong Linda} and Marketa Sjogren and Vinay, {D. G.} and Myriam Alexander and Yasuharu Tabara and Sue Shaw-Hawkins and Whincup, {Peter H.} and Yongmei Liu and Gang Shi and Johanna Kuusisto and Bamidele Tayo and Mark Seielstad and Xueling Sim and {Khanh-Dung Hoang Nguyen}, {[No Value]} and Terho Lehtimaki and Giuseppe Matullo and Ying Wu and Gaunt, {Tom R.} and Onland-Moret, {N. Charlotte} and Cooper, {Matthew N.} and Platou, {Carl G. P.} and Elin Org and Rebecca Hardy and Santosh Dahgam and Jutta Palmen and Veronique Vitart and Braund, {Peter S.} and Tatiana Kuznetsova and Uiterwaal, {Cuno S. P. M.} and Adebowale Adeyemo and Walter Palmas and Harry Campbell and Barbara Ludwig and Maciej Tomaszewski and Ioanna Tzoulaki and Palmer, {Nicholette D.} and Thor Aspelund and Melissa Garcia and Chang, {Yen-Pei C.} and O'Connell, {Jeffrey R.} and Steinle, {Nanette I.} and Grobbee, {Diederick E.} and Arking, {Dan E.} and Kardia, {Sharon L.} and Morrison, {Alanna C.} and Dena Hernandez and Samer Najjar and McArdle, {Wendy L.} and David Hadley and Brown, {Morris J.} and Connell, {John M.} and Hingorani, {Aroon D.} and Day, {Ian N. M.} and Lawlor, {Debbie A.} and Beilby, {John P.} and Lawrence, {Robert W.} and Robert Clarke and Hopewell, {Jemma C.} and Halit Ongen and Dreisbach, {Albert W.} and Yali Li and Young, {J. Hunter} and Bis, {Joshua C.} and Mika Kahonen and Jorma Viikari and Adair, {Linda S.} and Lee, {Nanette R.} and Ming-Huei Chen and Matthias Olden and Cristian Pattaro and Bolton, {Judith A. Hoffman} and Anna Köttgen and Sven Bergmann and Vincent Mooser and Nish Chaturvedi and Frayling, {Timothy M.} and Muhammad Islam and Jafar, {Tazeen H.} and Jeanette Erdmann and Kulkarni, {Smita R.} and Bornstein, {Stefan R.} and Juergen Graessler and Leif Groop and Voight, {Benjamin F.} and Johannes Kettunen and Philip Howard and Andrew Taylor and Simonetta Guarrera and Fulvio Ricceri and Valur Emilsson and Andrew Plump and Barroso, {Ine S.} and Kay-Tee Khaw and Weder, {Alan B.} and Hunt, {Steven C.} and Sun, {Yan V.} and Bergman, {Richard N.} and Collins, {Francis S.} and Bonnycastle, {Lori L.} and Scott, {Laura J.} and Stringham, {Heather M.} and Leena Peltonen and Markus Perola and Erkki Vartiainen and Stefan-Martin Brand and Staessen, {Jan A.} and Wang, {Thomas J.} and Burton, {Paul R.} and Artigas, {Maria Soler} and Yanbin Dong and Harold Snieder and Xiaoling Wang and Haidong Zhu and Lohman, {Kurt K.} and Rudock, {Megan E.} and Heckbert, {Susan R.} and Smith, {Nicholas L.} and Wiggins, {Kerri L.} and Ayo Doumatey and Daniel Shriner and Gudrun Veldre and Margus Viigimaa and Sanjay Kinra and Dorairaj Prabhakaran and Vikal Tripathy and Langefeld, {Carl D.} and Annika Rosengren and Thelle, {Dag S.} and Corsi, {Anna Maria} and Andrew Singleton and Terrence Forrester and Gina Hilton and McKenzie, {Colin A.} and Tunde Salako and Naoharu Iwai and Yoshikuni Kita and Toshio Ogihara and Takayoshi Ohkubo and Tomonori Okamura and Hirotsugu Ueshima and Satoshi Umemura and Susana Eyheramendy and Thomas Meitinger and Wichmann, {H. -Erich} and Cho, {Yoon Shin} and Hyung-Lae Kim and Jong-Young Lee and James Scott and Sehmi, {Joban S.} and Weihua Zhang and Bo Hedblad and Peter Nilsson and Smith, {George Davey} and Andrew Wong and Narisu Narisu and Alena Stancakova and Raffel, {Leslie J.} and Jie Yao and Sekar Kathiresan and O'Donnell, {Christopher J.} and Schwartz, {Stephen M.} and Ikram, {M. Arfan} and Longstreth, {W. T.} and Mosley, {Thomas H.} and Sudha Seshadri and Shrine, {Nick R. G.} and Wain, {Louise V.} and Morken, {Mario A.} and Swift, {Amy J.} and Jaana Laitinen and Inga Prokopenko and Paavo Zitting and Cooper, {Jackie A.} and Humphries, {Steve E.} and John Danesh and Asif Rasheed and Anuj Goel and Anders Hamsten and Hugh Watkins and Bakker, {Stephan J. L.} and {van Gilst}, {Wiek H.} and Janipalli, {Charles S.} and Mani, {K. Radha} and Yajnik, {Chittaranjan S.} and Albert Hofman and Mattace-Raso, {Francesco U. S.} and Oostra, {Ben A.} and Ayse Demirkan and Aaron Isaacs and Fernando Rivadeneira and Lakatta, {Edward G.} and Marco Orru and Angelo Scuteri and Mika Ala-Korpela and Kangas, {Antti J.} and Leo-Pekka Lyytikainen and Pasi Soininen and Taru Tukiainen and Peter Wurtz and Ong, {Rick Twee-Hee} and Marcus Doerr and Kroemer, {Heyo K.} and Uwe Voelker and Henry Voelzke and Pilar Galan and Serge Hercberg and Mark Lathrop and Diana Zelenika and Panos Deloukas and Massimo Mangino and Spector, {Tim D.} and Guangju Zhai and Meschia, {James F.} and Nalls, {Michael A.} and Pankaj Sharma and Janos Terzic and Kumar, {M. V. Kranthi} and Matthew Denniff and Ewa Zukowska-Szczechowska and Wagenknecht, {Lynne E.} and Fowkes, {F. Gerald R.} and Charchar, {Fadi J.} and Schwarz, {Peter E. H.} and Caroline Hayward and Xiuqing Guo and Charles Rotimi and Bots, {Michiel L.} and Eva Brand and Samani, {Nilesh J.} and Ozren Polasek and Talmud, {Philippa J.} and Fredrik Nyberg and Diana Kuh and Maris Laan and Kristian Hveem and Palmer, {Lyle J.} and {van der Schouw}, {Yvonne T.} and Casas, {Juan P.} and Mohlke, {Karen L.} and Paolo Vineis and Olli Raitakari and Ganesh, {Santhi K.} and Wong, {Tien Y.} and Tai, {E. Shyong} and Cooper, {Richard S.} and Markku Laakso and Rao, {Dabeeru C.} and Harris, {Tamara B.} and Morris, {Richard W.} and Dominiczak, {Anna F.} and Mika Kivimaki and Marmot, {Michael G.} and Tetsuro Miki and Danish Saleheen and Chandak, {Giriraj R.} and Josef Coresh and Gerjan Navis and Veikko Salomaa and Bok-Ghee Han and Xiaofeng Zhu and Kooner, {Jaspal S.} and Olle Melander and Ridker, {Paul M.} and Stefania Bandinelli and Gyllensten, {Ulf B.} and Wright, {Alan F.} and Wilson, {James F.} and Luigi Ferrucci and Martin Farrall and Jaakko Tuomilehto and Pramstaller, {Peter P.} and Roberto Elosua and Nicole Soranzo and Sijbrands, {Eric J. G.} and David Altshuler and Loos, {Ruth J. F.} and Shuldiner, {Alan R.} and Christian Gieger and Pierre Meneton and Uitterlinden, {Andre G.} and Wareham, {Nicholas J.} and Vilmundur Gudnason and Rotter, {Jerome I.} and Rainer Rettig and Manuela Uda and Strachan, {David P.} and Witteman, {Jacqueline C. M.} and Anna-Liisa Hartikainen and Beckmann, {Jacques S.} and Eric Boerwinkle and Vasan, {Ramachandran S.} and Michael Boehnke and Larson, {Martin G.} and Marjo-Riitta Jarvelin and Psaty, {Bruce M.} and Abecasis, {Goncalo R.} and Aravinda Chakravarti and Paul Elliott and {van Duijn}, {Cornelia M.} and Christopher Newton-Cheh and Daniel Levy and Caulfield, {Mark J.} and Toby Johnson and {CARDIoGRAM Consortium, KidneyGen Consortium, EchoGen Consortium, CKDGen Consortium, Int Consortium Blood Pressure Geno, CHARGE-HF Consortium}",
year = "2011",
month = "10",
doi = "10.1038/nature10405",
volume = "478",
pages = "103--109",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7367",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

AU - Ehret,Georg B.

AU - Munroe,Patricia B.

AU - Rice,Kenneth M.

AU - Bochud,Murielle

AU - Johnson,Andrew D.

AU - Chasman,Daniel I.

AU - Smith,Albert V.

AU - Tobin,Martin D.

AU - Verwoert,Germaine C.

AU - Hwang,Shih-Jen

AU - Pihur,Vasyl

AU - Vollenweider,Peter

AU - O'Reilly,Paul F.

AU - Amin,Najaf

AU - Bragg-Gresham,Jennifer L.

AU - Teumer,Alexander

AU - Glazer,Nicole L.

AU - Launer,Lenore

AU - Zhao,Jing Hua

AU - Aulchenko,Yurii

AU - Heath,Simon

AU - Sober,Siim

AU - Parsa,Afshin

AU - Luan,Jian'an

AU - Arora,Pankaj

AU - Dehghan,Abbas

AU - Zhang,Feng

AU - Lucas,Gavin

AU - Hicks,Andrew A.

AU - Jackson,Anne U.

AU - Peden,John F.

AU - Tanaka,Toshiko

AU - Wild,Sarah H.

AU - Rudan,Igor

AU - Igl,Wilmar

AU - Milaneschi,Yuri

AU - Parker,Alex N.

AU - Fava,Cristiano

AU - Chambers,John C.

AU - Fox,Ervin R.

AU - Kumari,Meena

AU - Go,Min Jin

AU - van der Harst,Pim

AU - Kao,Wen Hong Linda

AU - Sjogren,Marketa

AU - Vinay,D. G.

AU - Alexander,Myriam

AU - Tabara,Yasuharu

AU - Shaw-Hawkins,Sue

AU - Whincup,Peter H.

AU - Liu,Yongmei

AU - Shi,Gang

AU - Kuusisto,Johanna

AU - Tayo,Bamidele

AU - Seielstad,Mark

AU - Sim,Xueling

AU - Khanh-Dung Hoang Nguyen,[No Value]

AU - Lehtimaki,Terho

AU - Matullo,Giuseppe

AU - Wu,Ying

AU - Gaunt,Tom R.

AU - Onland-Moret,N. Charlotte

AU - Cooper,Matthew N.

AU - Platou,Carl G. P.

AU - Org,Elin

AU - Hardy,Rebecca

AU - Dahgam,Santosh

AU - Palmen,Jutta

AU - Vitart,Veronique

AU - Braund,Peter S.

AU - Kuznetsova,Tatiana

AU - Uiterwaal,Cuno S. P. M.

AU - Adeyemo,Adebowale

AU - Palmas,Walter

AU - Campbell,Harry

AU - Ludwig,Barbara

AU - Tomaszewski,Maciej

AU - Tzoulaki,Ioanna

AU - Palmer,Nicholette D.

AU - Aspelund,Thor

AU - Garcia,Melissa

AU - Chang,Yen-Pei C.

AU - O'Connell,Jeffrey R.

AU - Steinle,Nanette I.

AU - Grobbee,Diederick E.

AU - Arking,Dan E.

AU - Kardia,Sharon L.

AU - Morrison,Alanna C.

AU - Hernandez,Dena

AU - Najjar,Samer

AU - McArdle,Wendy L.

AU - Hadley,David

AU - Brown,Morris J.

AU - Connell,John M.

AU - Hingorani,Aroon D.

AU - Day,Ian N. M.

AU - Lawlor,Debbie A.

AU - Beilby,John P.

AU - Lawrence,Robert W.

AU - Clarke,Robert

AU - Hopewell,Jemma C.

AU - Ongen,Halit

AU - Dreisbach,Albert W.

AU - Li,Yali

AU - Young,J. Hunter

AU - Bis,Joshua C.

AU - Kahonen,Mika

AU - Viikari,Jorma

AU - Adair,Linda S.

AU - Lee,Nanette R.

AU - Chen,Ming-Huei

AU - Olden,Matthias

AU - Pattaro,Cristian

AU - Bolton,Judith A. Hoffman

AU - Köttgen,Anna

AU - Bergmann,Sven

AU - Mooser,Vincent

AU - Chaturvedi,Nish

AU - Frayling,Timothy M.

AU - Islam,Muhammad

AU - Jafar,Tazeen H.

AU - Erdmann,Jeanette

AU - Kulkarni,Smita R.

AU - Bornstein,Stefan R.

AU - Graessler,Juergen

AU - Groop,Leif

AU - Voight,Benjamin F.

AU - Kettunen,Johannes

AU - Howard,Philip

AU - Taylor,Andrew

AU - Guarrera,Simonetta

AU - Ricceri,Fulvio

AU - Emilsson,Valur

AU - Plump,Andrew

AU - Barroso,Ine S.

AU - Khaw,Kay-Tee

AU - Weder,Alan B.

AU - Hunt,Steven C.

AU - Sun,Yan V.

AU - Bergman,Richard N.

AU - Collins,Francis S.

AU - Bonnycastle,Lori L.

AU - Scott,Laura J.

AU - Stringham,Heather M.

AU - Peltonen,Leena

AU - Perola,Markus

AU - Vartiainen,Erkki

AU - Brand,Stefan-Martin

AU - Staessen,Jan A.

AU - Wang,Thomas J.

AU - Burton,Paul R.

AU - Artigas,Maria Soler

AU - Dong,Yanbin

AU - Snieder,Harold

AU - Wang,Xiaoling

AU - Zhu,Haidong

AU - Lohman,Kurt K.

AU - Rudock,Megan E.

AU - Heckbert,Susan R.

AU - Smith,Nicholas L.

AU - Wiggins,Kerri L.

AU - Doumatey,Ayo

AU - Shriner,Daniel

AU - Veldre,Gudrun

AU - Viigimaa,Margus

AU - Kinra,Sanjay

AU - Prabhakaran,Dorairaj

AU - Tripathy,Vikal

AU - Langefeld,Carl D.

AU - Rosengren,Annika

AU - Thelle,Dag S.

AU - Corsi,Anna Maria

AU - Singleton,Andrew

AU - Forrester,Terrence

AU - Hilton,Gina

AU - McKenzie,Colin A.

AU - Salako,Tunde

AU - Iwai,Naoharu

AU - Kita,Yoshikuni

AU - Ogihara,Toshio

AU - Ohkubo,Takayoshi

AU - Okamura,Tomonori

AU - Ueshima,Hirotsugu

AU - Umemura,Satoshi

AU - Eyheramendy,Susana

AU - Meitinger,Thomas

AU - Wichmann,H. -Erich

AU - Cho,Yoon Shin

AU - Kim,Hyung-Lae

AU - Lee,Jong-Young

AU - Scott,James

AU - Sehmi,Joban S.

AU - Zhang,Weihua

AU - Hedblad,Bo

AU - Nilsson,Peter

AU - Smith,George Davey

AU - Wong,Andrew

AU - Narisu,Narisu

AU - Stancakova,Alena

AU - Raffel,Leslie J.

AU - Yao,Jie

AU - Kathiresan,Sekar

AU - O'Donnell,Christopher J.

AU - Schwartz,Stephen M.

AU - Ikram,M. Arfan

AU - Longstreth,W. T.

AU - Mosley,Thomas H.

AU - Seshadri,Sudha

AU - Shrine,Nick R. G.

AU - Wain,Louise V.

AU - Morken,Mario A.

AU - Swift,Amy J.

AU - Laitinen,Jaana

AU - Prokopenko,Inga

AU - Zitting,Paavo

AU - Cooper,Jackie A.

AU - Humphries,Steve E.

AU - Danesh,John

AU - Rasheed,Asif

AU - Goel,Anuj

AU - Hamsten,Anders

AU - Watkins,Hugh

AU - Bakker,Stephan J. L.

AU - van Gilst,Wiek H.

AU - Janipalli,Charles S.

AU - Mani,K. Radha

AU - Yajnik,Chittaranjan S.

AU - Hofman,Albert

AU - Mattace-Raso,Francesco U. S.

AU - Oostra,Ben A.

AU - Demirkan,Ayse

AU - Isaacs,Aaron

AU - Rivadeneira,Fernando

AU - Lakatta,Edward G.

AU - Orru,Marco

AU - Scuteri,Angelo

AU - Ala-Korpela,Mika

AU - Kangas,Antti J.

AU - Lyytikainen,Leo-Pekka

AU - Soininen,Pasi

AU - Tukiainen,Taru

AU - Wurtz,Peter

AU - Ong,Rick Twee-Hee

AU - Doerr,Marcus

AU - Kroemer,Heyo K.

AU - Voelker,Uwe

AU - Voelzke,Henry

AU - Galan,Pilar

AU - Hercberg,Serge

AU - Lathrop,Mark

AU - Zelenika,Diana

AU - Deloukas,Panos

AU - Mangino,Massimo

AU - Spector,Tim D.

AU - Zhai,Guangju

AU - Meschia,James F.

AU - Nalls,Michael A.

AU - Sharma,Pankaj

AU - Terzic,Janos

AU - Kumar,M. V. Kranthi

AU - Denniff,Matthew

AU - Zukowska-Szczechowska,Ewa

AU - Wagenknecht,Lynne E.

AU - Fowkes,F. Gerald R.

AU - Charchar,Fadi J.

AU - Schwarz,Peter E. H.

AU - Hayward,Caroline

AU - Guo,Xiuqing

AU - Rotimi,Charles

AU - Bots,Michiel L.

AU - Brand,Eva

AU - Samani,Nilesh J.

AU - Polasek,Ozren

AU - Talmud,Philippa J.

AU - Nyberg,Fredrik

AU - Kuh,Diana

AU - Laan,Maris

AU - Hveem,Kristian

AU - Palmer,Lyle J.

AU - van der Schouw,Yvonne T.

AU - Casas,Juan P.

AU - Mohlke,Karen L.

AU - Vineis,Paolo

AU - Raitakari,Olli

AU - Ganesh,Santhi K.

AU - Wong,Tien Y.

AU - Tai,E. Shyong

AU - Cooper,Richard S.

AU - Laakso,Markku

AU - Rao,Dabeeru C.

AU - Harris,Tamara B.

AU - Morris,Richard W.

AU - Dominiczak,Anna F.

AU - Kivimaki,Mika

AU - Marmot,Michael G.

AU - Miki,Tetsuro

AU - Saleheen,Danish

AU - Chandak,Giriraj R.

AU - Coresh,Josef

AU - Navis,Gerjan

AU - Salomaa,Veikko

AU - Han,Bok-Ghee

AU - Zhu,Xiaofeng

AU - Kooner,Jaspal S.

AU - Melander,Olle

AU - Ridker,Paul M.

AU - Bandinelli,Stefania

AU - Gyllensten,Ulf B.

AU - Wright,Alan F.

AU - Wilson,James F.

AU - Ferrucci,Luigi

AU - Farrall,Martin

AU - Tuomilehto,Jaakko

AU - Pramstaller,Peter P.

AU - Elosua,Roberto

AU - Soranzo,Nicole

AU - Sijbrands,Eric J. G.

AU - Altshuler,David

AU - Loos,Ruth J. F.

AU - Shuldiner,Alan R.

AU - Gieger,Christian

AU - Meneton,Pierre

AU - Uitterlinden,Andre G.

AU - Wareham,Nicholas J.

AU - Gudnason,Vilmundur

AU - Rotter,Jerome I.

AU - Rettig,Rainer

AU - Uda,Manuela

AU - Strachan,David P.

AU - Witteman,Jacqueline C. M.

AU - Hartikainen,Anna-Liisa

AU - Beckmann,Jacques S.

AU - Boerwinkle,Eric

AU - Vasan,Ramachandran S.

AU - Boehnke,Michael

AU - Larson,Martin G.

AU - Jarvelin,Marjo-Riitta

AU - Psaty,Bruce M.

AU - Abecasis,Goncalo R.

AU - Chakravarti,Aravinda

AU - Elliott,Paul

AU - van Duijn,Cornelia M.

AU - Newton-Cheh,Christopher

AU - Levy,Daniel

AU - Caulfield,Mark J.

AU - Johnson,Toby

AU - CARDIoGRAM Consortium, KidneyGen Consortium, EchoGen Consortium, CKDGen Consortium, Int Consortium Blood Pressure Geno, CHARGE-HF Consortium

PY - 2011/10/6

Y1 - 2011/10/6

N2 - <p>Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (&gt;= 140 mm Hg systolic blood pressure or &gt;= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.</p>

AB - <p>Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (&gt;= 140 mm Hg systolic blood pressure or &gt;= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.</p>

KW - GENOME-WIDE ASSOCIATION

KW - COMMON VARIANTS

KW - HYPERTENSION

KW - METAANALYSIS

KW - LOCI

KW - POPULATION

KW - RELEVANCE

KW - RECEPTOR

KW - CLONING

KW - HEALTH

U2 - 10.1038/nature10405

DO - 10.1038/nature10405

M3 - Article

VL - 478

SP - 103

EP - 109

JO - Nature

T2 - Nature

JF - Nature

SN - 0028-0836

IS - 7367

ER -

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