Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression. / McIntosh, Andrew M.; Simen, Arthur A.; Evans, Kathryn L.; Hall, Jeremy; MacIntyre, Donald J.; Blackwood, Douglas; Morris, Andrew D.; Smith, Blair H.; Dominiczak, Anna; Porteous, David; Deary, Ian J.; Thomson, Pippa A.
In: Frontiers in Genetics, Vol. 3, 2012, 00116.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression
A1 - McIntosh,Andrew M.
A1 - Simen,Arthur A.
A1 - Evans,Kathryn L.
A1 - Hall,Jeremy
A1 - MacIntyre,Donald J.
A1 - Blackwood,Douglas
A1 - Morris,Andrew D.
A1 - Smith,Blair H.
A1 - Dominiczak,Anna
A1 - Porteous,David
A1 - Deary,Ian J.
A1 - Thomson,Pippa A.
AU - McIntosh,Andrew M.
AU - Simen,Arthur A.
AU - Evans,Kathryn L.
AU - Hall,Jeremy
AU - MacIntyre,Donald J.
AU - Blackwood,Douglas
AU - Morris,Andrew D.
AU - Smith,Blair H.
AU - Dominiczak,Anna
AU - Porteous,David
AU - Deary,Ian J.
AU - Thomson,Pippa A.
PY - 2012
Y1 - 2012
N2 - Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.
AB - Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.
KW - Stress
KW - Depression
KW - HCN channel
KW - Genetics
KW - Association
KW - Cognition
KW - Neuroticism
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84876069081&md5=46383670e2b685e6cc7f4d168f6b6e57
U2 - 10.3389/fgene.2012.00116
DO - 10.3389/fgene.2012.00116
M1 - Article
JO - Frontiers in Genetics
JF - Frontiers in Genetics
VL - 3
ER -