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Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression

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Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression. / McIntosh, Andrew M.; Simen, Arthur A.; Evans, Kathryn L.; Hall, Jeremy; MacIntyre, Donald J.; Blackwood, Douglas; Morris, Andrew D.; Smith, Blair H.; Dominiczak, Anna; Porteous, David; Deary, Ian J.; Thomson, Pippa A.

In: Frontiers in Genetics, Vol. 3, 00116, 2012.

Research output: Contribution to journalArticle

Harvard

McIntosh, AM, Simen, AA, Evans, KL, Hall, J, MacIntyre, DJ, Blackwood, D, Morris, AD, Smith, BH, Dominiczak, A, Porteous, D, Deary, IJ & Thomson, PA 2012, 'Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression' Frontiers in Genetics, vol 3, 00116., 10.3389/fgene.2012.00116

APA

McIntosh, A. M., Simen, A. A., Evans, K. L., Hall, J., MacIntyre, D. J., Blackwood, D., ... Thomson, P. A. (2012). Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression. Frontiers in Genetics, 3, [00116]. 10.3389/fgene.2012.00116

Vancouver

McIntosh AM, Simen AA, Evans KL, Hall J, MacIntyre DJ, Blackwood D et al. Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression. Frontiers in Genetics. 2012;3. 00116. Available from: 10.3389/fgene.2012.00116

Author

McIntosh, Andrew M.; Simen, Arthur A.; Evans, Kathryn L.; Hall, Jeremy; MacIntyre, Donald J.; Blackwood, Douglas; Morris, Andrew D.; Smith, Blair H.; Dominiczak, Anna; Porteous, David; Deary, Ian J.; Thomson, Pippa A. / Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression.

In: Frontiers in Genetics, Vol. 3, 00116, 2012.

Research output: Contribution to journalArticle

Bibtex - Download

@article{595fe2459d8c4c5c970216a4853139e7,
title = "Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression",
keywords = "Stress, Depression, HCN channel, Genetics, Association, Cognition, Neuroticism",
author = "McIntosh, {Andrew M.} and Simen, {Arthur A.} and Evans, {Kathryn L.} and Jeremy Hall and MacIntyre, {Donald J.} and Douglas Blackwood and Morris, {Andrew D.} and Smith, {Blair H.} and Anna Dominiczak and David Porteous and Deary, {Ian J.} and Thomson, {Pippa A.}",
note = "Copyright 2013 Elsevier B.V., All rights reserved.",
year = "2012",
doi = "10.3389/fgene.2012.00116",
volume = "3",
journal = "Frontiers in Genetics",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression

A1 - McIntosh,Andrew M.

A1 - Simen,Arthur A.

A1 - Evans,Kathryn L.

A1 - Hall,Jeremy

A1 - MacIntyre,Donald J.

A1 - Blackwood,Douglas

A1 - Morris,Andrew D.

A1 - Smith,Blair H.

A1 - Dominiczak,Anna

A1 - Porteous,David

A1 - Deary,Ian J.

A1 - Thomson,Pippa A.

AU - McIntosh,Andrew M.

AU - Simen,Arthur A.

AU - Evans,Kathryn L.

AU - Hall,Jeremy

AU - MacIntyre,Donald J.

AU - Blackwood,Douglas

AU - Morris,Andrew D.

AU - Smith,Blair H.

AU - Dominiczak,Anna

AU - Porteous,David

AU - Deary,Ian J.

AU - Thomson,Pippa A.

PY - 2012

Y1 - 2012

N2 - Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.

AB - Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.

KW - Stress

KW - Depression

KW - HCN channel

KW - Genetics

KW - Association

KW - Cognition

KW - Neuroticism

UR - http://www.scopus.com/inward/record.url?scp=84876069081&partnerID=8YFLogxK

U2 - 10.3389/fgene.2012.00116

DO - 10.3389/fgene.2012.00116

M1 - Article

JO - Frontiers in Genetics

JF - Frontiers in Genetics

VL - 3

ER -

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