Discovery - University of Dundee - Online Publications

Library & Learning Centre

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Research output: Contribution to journalArticle

View graph of relations

Authors

  • Maria Soler Artigas
  • Daan W. Loth
  • Louise V. Wain
  • Sina A. Gharib
  • Ma'en Obeidat
  • Wenbo Tang
  • Guangju Zhai
  • Jing Hua Zhao
  • Albert Vernon Smith
  • Jennifer E. Huffman
  • Eva Albrecht
  • Catherine M. Jackson
  • David M. Evans
  • Gemma Cadby
  • Myriam Fornage
  • Ani Manichaikul
  • Lorna M. Lopez
  • Toby Johnson
  • Melinda C. Aldrich
  • Thor Aspelund
  • And 150 others
  • Ines Barroso
  • Harry Campbell
  • Patricia A. Cassano
  • David J. Couper
  • Gudny Eiriksdottir
  • Nora Franceschini
  • Melissa Garcia
  • Christian Gieger
  • Gauti Kjartan Gislason
  • Ivica Grkovic
  • Christopher J. Hammond
  • Dana B. Hancock
  • Tamara B. Harris
  • Adaikalavan Ramasamy
  • Susan R. Heckbert
  • Markku Heliovaara
  • Georg Homuth
  • Pirro G. Hysi
  • Alan L. James
  • Stipan Jankovic
  • Bonnie R. Joubert
  • Stefan Karrasch
  • Norman Klopp
  • Beate Koch
  • Stephen B. Kritchevsky
  • Lenore J. Launer
  • Yongmei Liu
  • Laura R. Loehr
  • Kurt Lohman
  • Ruth J. F. Loos
  • Thomas Lumley
  • Khalid A. Al Balushi
  • Wei Q. Ang
  • R. Graham Barr
  • John Beilby
  • John D. Blakey
  • Mladen Boban
  • Vesna Boraska
  • Jonas Brisman
  • John R. Britton
  • Guy G. Brusselle
  • Cyrus Cooper
  • Ivan Curjuric
  • Santosh Dahgam
  • Ian J. Deary
  • Shah Ebrahim
  • Mark Eijgelsheim
  • Clyde Francks
  • Darya Gaysina
  • Raquel Granell
  • Xiangjun Gu
  • John L. Hankinson
  • Rebecca Hardy
  • Sarah E. Harris
  • John Henderson
  • Amanda Henry
  • Aroon D. Hingorani
  • Albert Hofman
  • Patrick G. Holt
  • Jennie Hui
  • Michael L. Hunter
  • Medea Imboden
  • Karen A. Jameson
  • Shona M. Kerr
  • Ivana Kolcic
  • Florian Kronenberg
  • Jason Z. Liu
  • Jonathan Marchini
  • Tricia McKeever
  • Andrew D. Morris
  • Anna-Carin Olin
  • David J. Porteous
  • Dirkje S. Postma
  • Stephen S. Rich
  • Susan M. Ring
  • Fernando Rivadeneira
  • Thierry Rochat
  • Avan Aihie Sayer
  • Ian Sayers
  • Peter D. Sly
  • George Davey Smith
  • Akshay Sood
  • John M. Starr
  • Andre G. Uitterlinden
  • Judith M. Vonk
  • S. Goya Wannamethee
  • Peter H. Whincup
  • Cisca Wijmenga
  • O. Dale Williams
  • Andrew Wong
  • Massimo Mangino
  • Kristin D. Marciante
  • Wendy L. McArdle
  • Bernd Meibohm
  • Alanna C. Morrison
  • Kari E. North
  • Ernst Omenaas
  • Lyle J. Palmer
  • Kirsi H. Pietilainen
  • Isabelle Pin
  • Ozren Polasek
  • Anneli Pouta
  • Bruce M. Psaty
  • Anna-Liisa Hartikainen
  • Taina Rantanen
  • Samuli Ripatti
  • Jerome I. Rotter
  • Igor Rudan
  • Alicja R. Rudnicka
  • Holger Schulz
  • So-Youn Shin
  • Tim D. Spector
  • Ida Surakka
  • Veronique Vitart
  • Henry Voelzke
  • Nicholas J. Wareham
  • Nicole M. Warrington
  • H-Erich Wichmann
  • Sarah H. Wild
  • Jemma B. Wilk
  • Matthias Wjst
  • Alan F. Wright
  • Lina Zgaga
  • Tatijana Zemunik
  • Craig E. Pennell
  • Fredrik Nyberg
  • Diana Kuh
  • John W. Holloway
  • H. Marike Boezen
  • Debbie A. Lawlor
  • Richard W. Morris
  • Nicole Probst-Hensch
  • Jaakko Kaprio
  • James F. Wilson
  • Caroline Hayward
  • Mika Kahonen
  • Joachim Heinrich
  • Arthur W. Musk
  • Deborah L. Jarvis
  • Sven Glaeser
  • Marjo-Riitta Jarvelin
  • Bruno H. Ch Stricker
  • Paul Elliott
  • George T. O'Connor
  • David P. Strachan
  • Stephanie J. London
  • Ian P. Hall
  • Vilmundur Gudnason
  • Martin D. Tobin
  • GIANT Consortium, Int Lung Canc Consortium

Research units

Info

Original languageEnglish
Pages1082-U70
Number of pages11
JournalNature Genetics
Journal publication dateNov 2011
Journal number11
Volume43
DOIs
StatePublished

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Documents

Library & Learning Centre

Contact | Accessibility | Policy