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Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

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Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. / Bellenguez, Celine; Bevan, Steve; Gschwendtner, Andreas; Spencer, Chris C. A.; Burgess, Annette I.; Pirinen, Matti; Jackson, Caroline A.; Traylor, Matthew; Strange, Amy; Su, Zhan; Band, Gavin; Syme, Paul D.; Malik, Rainer; Pera, Joanna; Norrving, Bo; Lemmens, Robin; Freeman, Colin; Schanz, Renata; James, Tom; Poole, Deborah; Murphy, Lee; Segal, Helen; Cortellini, Lynelle; Cheng, Yu-Ching; Woo, Daniel; Nalls, Michael A.; Müller-Myhsok, Bertram; Meisinger, Christa; Seedorf, Udo; Ross-Adams, Helen; Boonen, Steven; Wloch-Kopec, Dorota; Valant, Valerie; Slark, Julia; Furie, Karen; Delavaran, Hossein; Langford, Cordelia; Deloukas, Panos; Edkins, Sarah; Hunt, Sarah; Gray, Emma; Dronov, Serge; Peltonen, Leena; Gretarsdottir, Solveig; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Stefansson, Kari; Boncoraglio, Giorgio B.; Parati, Eugenio A.; Attia, John; Holliday, Elizabeth; Levi, Chris; Franzosi, Maria-Grazia; Goel, Anuj; Helgadottir, Anna; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz; Mathew, Christopher G.; Palmer, Colin N. A.; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Wood, Nicholas W.; Worrall, Bradford B.; Kittner, Steven J.; Mitchell, Braxton D.; Kissela, Brett; Meschia, James F.; Thijs, Vincent; Lindgren, Arne; Macleod, Mary Joan; Slowik, Agnieszka; Walters, Matthew; Rosand, Jonathan; Sharma, Pankaj; Farrall, Martin; Sudlow, Cathie L. M.; Rothwell, Peter M.; Dichgans, Martin; Donnelly, Peter; Markus, Hugh S.; WTCCC2, ISGC.

In: Nature Genetics, Vol. 44, No. 3, 03.2012, p. 328-U141.

Research output: Contribution to journalArticle

Harvard

Bellenguez, C, Bevan, S, Gschwendtner, A, Spencer, CCA, Burgess, AI, Pirinen, M, Jackson, CA, Traylor, M, Strange, A, Su, Z, Band, G, Syme, PD, Malik, R, Pera, J, Norrving, B, Lemmens, R, Freeman, C, Schanz, R, James, T, Poole, D, Murphy, L, Segal, H, Cortellini, L, Cheng, Y-C, Woo, D, Nalls, MA, Müller-Myhsok, B, Meisinger, C, Seedorf, U, Ross-Adams, H, Boonen, S, Wloch-Kopec, D, Valant, V, Slark, J, Furie, K, Delavaran, H, Langford, C, Deloukas, P, Edkins, S, Hunt, S, Gray, E, Dronov, S, Peltonen, L, Gretarsdottir, S, Thorleifsson, G, Thorsteinsdottir, U, Stefansson, K, Boncoraglio, GB, Parati, EA, Attia, J, Holliday, E, Levi, C, Franzosi, M-G, Goel, A, Helgadottir, A, Blackwell, JM, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Duncanson, A, Jankowski, J, Mathew, CG, Palmer, CNA, Plomin, R, Rautanen, A, Sawcer, SJ, Trembath, RC, Viswanathan, AC, Wood, NW, Worrall, BB, Kittner, SJ, Mitchell, BD, Kissela, B, Meschia, JF, Thijs, V, Lindgren, A, Macleod, MJ, Slowik, A, Walters, M, Rosand, J, Sharma, P, Farrall, M, Sudlow, CLM, Rothwell, PM, Dichgans, M, Donnelly, P, Markus, HS & WTCCC2, ISGC 2012, 'Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke' Nature Genetics, vol 44, no. 3, pp. 328-U141., 10.1038/ng.1081

APA

Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, C. C. A., Burgess, A. I., Pirinen, M., ... WTCCC2, ISGC (2012). Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nature Genetics, 44(3), 328-U141. 10.1038/ng.1081

Vancouver

Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M et al. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nature Genetics. 2012 Mar;44(3):328-U141. Available from: 10.1038/ng.1081

Author

Bellenguez, Celine; Bevan, Steve; Gschwendtner, Andreas; Spencer, Chris C. A.; Burgess, Annette I.; Pirinen, Matti; Jackson, Caroline A.; Traylor, Matthew; Strange, Amy; Su, Zhan; Band, Gavin; Syme, Paul D.; Malik, Rainer; Pera, Joanna; Norrving, Bo; Lemmens, Robin; Freeman, Colin; Schanz, Renata; James, Tom; Poole, Deborah; Murphy, Lee; Segal, Helen; Cortellini, Lynelle; Cheng, Yu-Ching; Woo, Daniel; Nalls, Michael A.; Müller-Myhsok, Bertram; Meisinger, Christa; Seedorf, Udo; Ross-Adams, Helen; Boonen, Steven; Wloch-Kopec, Dorota; Valant, Valerie; Slark, Julia; Furie, Karen; Delavaran, Hossein; Langford, Cordelia; Deloukas, Panos; Edkins, Sarah; Hunt, Sarah; Gray, Emma; Dronov, Serge; Peltonen, Leena; Gretarsdottir, Solveig; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Stefansson, Kari; Boncoraglio, Giorgio B.; Parati, Eugenio A.; Attia, John; Holliday, Elizabeth; Levi, Chris; Franzosi, Maria-Grazia; Goel, Anuj; Helgadottir, Anna; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz; Mathew, Christopher G.; Palmer, Colin N. A.; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Wood, Nicholas W.; Worrall, Bradford B.; Kittner, Steven J.; Mitchell, Braxton D.; Kissela, Brett; Meschia, James F.; Thijs, Vincent; Lindgren, Arne; Macleod, Mary Joan; Slowik, Agnieszka; Walters, Matthew; Rosand, Jonathan; Sharma, Pankaj; Farrall, Martin; Sudlow, Cathie L. M.; Rothwell, Peter M.; Dichgans, Martin; Donnelly, Peter; Markus, Hugh S.; WTCCC2, ISGC / Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.

In: Nature Genetics, Vol. 44, No. 3, 03.2012, p. 328-U141.

Research output: Contribution to journalArticle

Bibtex - Download

@article{566d7d9a1091472c8b47d05b392af375,
title = "Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke",
author = "Celine Bellenguez and Steve Bevan and Andreas Gschwendtner and Spencer, {Chris C. A.} and Burgess, {Annette I.} and Matti Pirinen and Jackson, {Caroline A.} and Matthew Traylor and Amy Strange and Zhan Su and Gavin Band and Syme, {Paul D.} and Rainer Malik and Joanna Pera and Bo Norrving and Robin Lemmens and Colin Freeman and Renata Schanz and Tom James and Deborah Poole and Lee Murphy and Helen Segal and Lynelle Cortellini and Yu-Ching Cheng and Daniel Woo and Nalls, {Michael A.} and Bertram Müller-Myhsok and Christa Meisinger and Udo Seedorf and Helen Ross-Adams and Steven Boonen and Dorota Wloch-Kopec and Valerie Valant and Julia Slark and Karen Furie and Hossein Delavaran and Cordelia Langford and Panos Deloukas and Sarah Edkins and Sarah Hunt and Emma Gray and Serge Dronov and Leena Peltonen and Solveig Gretarsdottir and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Kari Stefansson and Boncoraglio, {Giorgio B.} and Parati, {Eugenio A.} and John Attia and Elizabeth Holliday and Chris Levi and Maria-Grazia Franzosi and Anuj Goel and Anna Helgadottir and Blackwell, {Jenefer M.} and Elvira Bramon and Brown, {Matthew A.} and Casas, {Juan P.} and Aiden Corvin and Audrey Duncanson and Janusz Jankowski and Mathew, {Christopher G.} and Palmer, {Colin N. A.} and Robert Plomin and Anna Rautanen and Sawcer, {Stephen J.} and Trembath, {Richard C.} and Viswanathan, {Ananth C.} and Wood, {Nicholas W.} and Worrall, {Bradford B.} and Kittner, {Steven J.} and Mitchell, {Braxton D.} and Brett Kissela and Meschia, {James F.} and Vincent Thijs and Arne Lindgren and Macleod, {Mary Joan} and Agnieszka Slowik and Matthew Walters and Jonathan Rosand and Pankaj Sharma and Martin Farrall and Sudlow, {Cathie L. M.} and Rothwell, {Peter M.} and Martin Dichgans and Peter Donnelly and Markus, {Hugh S.} and {WTCCC2, ISGC}",
year = "2012",
doi = "10.1038/ng.1081",
volume = "44",
number = "3",
pages = "328--U141",
journal = "Nature Genetics",
issn = "1061-4036",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

A1 - Bellenguez,Celine

A1 - Bevan,Steve

A1 - Gschwendtner,Andreas

A1 - Spencer,Chris C. A.

A1 - Burgess,Annette I.

A1 - Pirinen,Matti

A1 - Jackson,Caroline A.

A1 - Traylor,Matthew

A1 - Strange,Amy

A1 - Su,Zhan

A1 - Band,Gavin

A1 - Syme,Paul D.

A1 - Malik,Rainer

A1 - Pera,Joanna

A1 - Norrving,Bo

A1 - Lemmens,Robin

A1 - Freeman,Colin

A1 - Schanz,Renata

A1 - James,Tom

A1 - Poole,Deborah

A1 - Murphy,Lee

A1 - Segal,Helen

A1 - Cortellini,Lynelle

A1 - Cheng,Yu-Ching

A1 - Woo,Daniel

A1 - Nalls,Michael A.

A1 - Müller-Myhsok,Bertram

A1 - Meisinger,Christa

A1 - Seedorf,Udo

A1 - Ross-Adams,Helen

A1 - Boonen,Steven

A1 - Wloch-Kopec,Dorota

A1 - Valant,Valerie

A1 - Slark,Julia

A1 - Furie,Karen

A1 - Delavaran,Hossein

A1 - Langford,Cordelia

A1 - Deloukas,Panos

A1 - Edkins,Sarah

A1 - Hunt,Sarah

A1 - Gray,Emma

A1 - Dronov,Serge

A1 - Peltonen,Leena

A1 - Gretarsdottir,Solveig

A1 - Thorleifsson,Gudmar

A1 - Thorsteinsdottir,Unnur

A1 - Stefansson,Kari

A1 - Boncoraglio,Giorgio B.

A1 - Parati,Eugenio A.

A1 - Attia,John

A1 - Holliday,Elizabeth

A1 - Levi,Chris

A1 - Franzosi,Maria-Grazia

A1 - Goel,Anuj

A1 - Helgadottir,Anna

A1 - Blackwell,Jenefer M.

A1 - Bramon,Elvira

A1 - Brown,Matthew A.

A1 - Casas,Juan P.

A1 - Corvin,Aiden

A1 - Duncanson,Audrey

A1 - Jankowski,Janusz

A1 - Mathew,Christopher G.

A1 - Palmer,Colin N. A.

A1 - Plomin,Robert

A1 - Rautanen,Anna

A1 - Sawcer,Stephen J.

A1 - Trembath,Richard C.

A1 - Viswanathan,Ananth C.

A1 - Wood,Nicholas W.

A1 - Worrall,Bradford B.

A1 - Kittner,Steven J.

A1 - Mitchell,Braxton D.

A1 - Kissela,Brett

A1 - Meschia,James F.

A1 - Thijs,Vincent

A1 - Lindgren,Arne

A1 - Macleod,Mary Joan

A1 - Slowik,Agnieszka

A1 - Walters,Matthew

A1 - Rosand,Jonathan

A1 - Sharma,Pankaj

A1 - Farrall,Martin

A1 - Sudlow,Cathie L. M.

A1 - Rothwell,Peter M.

A1 - Dichgans,Martin

A1 - Donnelly,Peter

A1 - Markus,Hugh S.

A1 - WTCCC2, ISGC

AU - Bellenguez,Celine

AU - Bevan,Steve

AU - Gschwendtner,Andreas

AU - Spencer,Chris C. A.

AU - Burgess,Annette I.

AU - Pirinen,Matti

AU - Jackson,Caroline A.

AU - Traylor,Matthew

AU - Strange,Amy

AU - Su,Zhan

AU - Band,Gavin

AU - Syme,Paul D.

AU - Malik,Rainer

AU - Pera,Joanna

AU - Norrving,Bo

AU - Lemmens,Robin

AU - Freeman,Colin

AU - Schanz,Renata

AU - James,Tom

AU - Poole,Deborah

AU - Murphy,Lee

AU - Segal,Helen

AU - Cortellini,Lynelle

AU - Cheng,Yu-Ching

AU - Woo,Daniel

AU - Nalls,Michael A.

AU - Müller-Myhsok,Bertram

AU - Meisinger,Christa

AU - Seedorf,Udo

AU - Ross-Adams,Helen

AU - Boonen,Steven

AU - Wloch-Kopec,Dorota

AU - Valant,Valerie

AU - Slark,Julia

AU - Furie,Karen

AU - Delavaran,Hossein

AU - Langford,Cordelia

AU - Deloukas,Panos

AU - Edkins,Sarah

AU - Hunt,Sarah

AU - Gray,Emma

AU - Dronov,Serge

AU - Peltonen,Leena

AU - Gretarsdottir,Solveig

AU - Thorleifsson,Gudmar

AU - Thorsteinsdottir,Unnur

AU - Stefansson,Kari

AU - Boncoraglio,Giorgio B.

AU - Parati,Eugenio A.

AU - Attia,John

AU - Holliday,Elizabeth

AU - Levi,Chris

AU - Franzosi,Maria-Grazia

AU - Goel,Anuj

AU - Helgadottir,Anna

AU - Blackwell,Jenefer M.

AU - Bramon,Elvira

AU - Brown,Matthew A.

AU - Casas,Juan P.

AU - Corvin,Aiden

AU - Duncanson,Audrey

AU - Jankowski,Janusz

AU - Mathew,Christopher G.

AU - Palmer,Colin N. A.

AU - Plomin,Robert

AU - Rautanen,Anna

AU - Sawcer,Stephen J.

AU - Trembath,Richard C.

AU - Viswanathan,Ananth C.

AU - Wood,Nicholas W.

AU - Worrall,Bradford B.

AU - Kittner,Steven J.

AU - Mitchell,Braxton D.

AU - Kissela,Brett

AU - Meschia,James F.

AU - Thijs,Vincent

AU - Lindgren,Arne

AU - Macleod,Mary Joan

AU - Slowik,Agnieszka

AU - Walters,Matthew

AU - Rosand,Jonathan

AU - Sharma,Pankaj

AU - Farrall,Martin

AU - Sudlow,Cathie L. M.

AU - Rothwell,Peter M.

AU - Dichgans,Martin

AU - Donnelly,Peter

AU - Markus,Hugh S.

AU - WTCCC2, ISGC

PY - 2012/3

Y1 - 2012/3

N2 - <p>Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.</p>

AB - <p>Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.</p>

U2 - 10.1038/ng.1081

DO - 10.1038/ng.1081

M1 - Article

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 3

VL - 44

SP - 328-U141

ER -

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