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Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci

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Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. / Ludwig, Kerstin U.; Mangold, Elisabeth (Lead / Corresponding author); Herms, Stefan; Nowak, Stefanie; Reutter, Heiko; Paul, Anna; Becker, Jessica; Herberz, Ruth; AlChawa, Taofik; Nasser, Entessar; Boehmer, Anne C.; Mattheisen, Manuel; Alblas, Margrieta A.; Barth, Sandra; Kluck, Nadine; Lauster, Carola; Braumann, Bert; Reich, Rudolf H.; Hemprich, Alexander; Poetzsch, Simone; Blaumeiser, Bettina; Daratsianos, Nikolaos; Kreusch, Thomas; Murray, Jeffrey C.; Marazita, Mary L.; Ruczinski, Ingo; Scott, Alan F.; Beaty, Terri H.; Kramer, Franz-Josef; Wienker, Thomas F.; Steegers-Theunissen, Regine P.; Rubini, Michele; Mossey, Peter A.; Hoffmann, Per; Lange, Christoph; Cichon, Sven; Propping, Peter; Knapp, Michael; Noethen, Markus M.

In: Nature Genetics, Vol. 44, No. 9, 09.2012, p. 968-971.

Research output: Contribution to journalArticle

Harvard

Ludwig, KU, Mangold, E, Herms, S, Nowak, S, Reutter, H, Paul, A, Becker, J, Herberz, R, AlChawa, T, Nasser, E, Boehmer, AC, Mattheisen, M, Alblas, MA, Barth, S, Kluck, N, Lauster, C, Braumann, B, Reich, RH, Hemprich, A, Poetzsch, S, Blaumeiser, B, Daratsianos, N, Kreusch, T, Murray, JC, Marazita, ML, Ruczinski, I, Scott, AF, Beaty, TH, Kramer, F-J, Wienker, TF, Steegers-Theunissen, RP, Rubini, M, Mossey, PA, Hoffmann, P, Lange, C, Cichon, S, Propping, P, Knapp, M & Noethen, MM 2012, 'Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci' Nature Genetics, vol 44, no. 9, pp. 968-971.

APA

Ludwig, K. U., Mangold, E., Herms, S., Nowak, S., Reutter, H., Paul, A., Becker, J., Herberz, R., AlChawa, T., Nasser, E., Boehmer, A. C., Mattheisen, M., Alblas, M. A., Barth, S., Kluck, N., Lauster, C., Braumann, B., Reich, R. H., Hemprich, A., Poetzsch, S., Blaumeiser, B., Daratsianos, N., Kreusch, T., Murray, J. C., Marazita, M. L., Ruczinski, I., Scott, A. F., Beaty, T. H., Kramer, F-J., Wienker, T. F., Steegers-Theunissen, R. P., Rubini, M., Mossey, P. A., Hoffmann, P., Lange, C., Cichon, S., Propping, P., Knapp, M., & Noethen, M. M. (2012). Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nature Genetics, 44(9), 968-971doi: 10.1038/ng.2360

Vancouver

Ludwig KU, Mangold E, Herms S, Nowak S, Reutter H, Paul A et al. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nature Genetics. 2012 Sep;44(9):968-971.

Author

Ludwig, Kerstin U.; Mangold, Elisabeth (Lead / Corresponding author); Herms, Stefan; Nowak, Stefanie; Reutter, Heiko; Paul, Anna; Becker, Jessica; Herberz, Ruth; AlChawa, Taofik; Nasser, Entessar; Boehmer, Anne C.; Mattheisen, Manuel; Alblas, Margrieta A.; Barth, Sandra; Kluck, Nadine; Lauster, Carola; Braumann, Bert; Reich, Rudolf H.; Hemprich, Alexander; Poetzsch, Simone; Blaumeiser, Bettina; Daratsianos, Nikolaos; Kreusch, Thomas; Murray, Jeffrey C.; Marazita, Mary L.; Ruczinski, Ingo; Scott, Alan F.; Beaty, Terri H.; Kramer, Franz-Josef; Wienker, Thomas F.; Steegers-Theunissen, Regine P.; Rubini, Michele; Mossey, Peter A.; Hoffmann, Per; Lange, Christoph; Cichon, Sven; Propping, Peter; Knapp, Michael; Noethen, Markus M. / Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.

In: Nature Genetics, Vol. 44, No. 9, 09.2012, p. 968-971.

Research output: Contribution to journalArticle

Bibtex - Download

@article{f2521f1bcbb849ab9580322ba8ad586d,
title = "Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci",
author = "Ludwig, {Kerstin U.} and Elisabeth Mangold and Stefan Herms and Stefanie Nowak and Heiko Reutter and Anna Paul and Jessica Becker and Ruth Herberz and Taofik AlChawa and Entessar Nasser and Boehmer, {Anne C.} and Manuel Mattheisen and Alblas, {Margrieta A.} and Sandra Barth and Nadine Kluck and Carola Lauster and Bert Braumann and Reich, {Rudolf H.} and Alexander Hemprich and Simone Poetzsch and Bettina Blaumeiser and Nikolaos Daratsianos and Thomas Kreusch and Murray, {Jeffrey C.} and Marazita, {Mary L.} and Ingo Ruczinski and Scott, {Alan F.} and Beaty, {Terri H.} and Franz-Josef Kramer and Wienker, {Thomas F.} and Steegers-Theunissen, {Regine P.} and Michele Rubini and Mossey, {Peter A.} and Per Hoffmann and Christoph Lange and Sven Cichon and Peter Propping and Michael Knapp and Noethen, {Markus M.}",
year = "2012",
volume = "44",
number = "9",
pages = "968--971",
journal = "Nature Genetics",
issn = "1061-4036",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci

A1 - Ludwig,Kerstin U.

A1 - Mangold,Elisabeth

A1 - Herms,Stefan

A1 - Nowak,Stefanie

A1 - Reutter,Heiko

A1 - Paul,Anna

A1 - Becker,Jessica

A1 - Herberz,Ruth

A1 - AlChawa,Taofik

A1 - Nasser,Entessar

A1 - Boehmer,Anne C.

A1 - Mattheisen,Manuel

A1 - Alblas,Margrieta A.

A1 - Barth,Sandra

A1 - Kluck,Nadine

A1 - Lauster,Carola

A1 - Braumann,Bert

A1 - Reich,Rudolf H.

A1 - Hemprich,Alexander

A1 - Poetzsch,Simone

A1 - Blaumeiser,Bettina

A1 - Daratsianos,Nikolaos

A1 - Kreusch,Thomas

A1 - Murray,Jeffrey C.

A1 - Marazita,Mary L.

A1 - Ruczinski,Ingo

A1 - Scott,Alan F.

A1 - Beaty,Terri H.

A1 - Kramer,Franz-Josef

A1 - Wienker,Thomas F.

A1 - Steegers-Theunissen,Regine P.

A1 - Rubini,Michele

A1 - Mossey,Peter A.

A1 - Hoffmann,Per

A1 - Lange,Christoph

A1 - Cichon,Sven

A1 - Propping,Peter

A1 - Knapp,Michael

A1 - Noethen,Markus M.

AU - Ludwig,Kerstin U.

AU - Mangold,Elisabeth

AU - Herms,Stefan

AU - Nowak,Stefanie

AU - Reutter,Heiko

AU - Paul,Anna

AU - Becker,Jessica

AU - Herberz,Ruth

AU - AlChawa,Taofik

AU - Nasser,Entessar

AU - Boehmer,Anne C.

AU - Mattheisen,Manuel

AU - Alblas,Margrieta A.

AU - Barth,Sandra

AU - Kluck,Nadine

AU - Lauster,Carola

AU - Braumann,Bert

AU - Reich,Rudolf H.

AU - Hemprich,Alexander

AU - Poetzsch,Simone

AU - Blaumeiser,Bettina

AU - Daratsianos,Nikolaos

AU - Kreusch,Thomas

AU - Murray,Jeffrey C.

AU - Marazita,Mary L.

AU - Ruczinski,Ingo

AU - Scott,Alan F.

AU - Beaty,Terri H.

AU - Kramer,Franz-Josef

AU - Wienker,Thomas F.

AU - Steegers-Theunissen,Regine P.

AU - Rubini,Michele

AU - Mossey,Peter A.

AU - Hoffmann,Per

AU - Lange,Christoph

AU - Cichon,Sven

AU - Propping,Peter

AU - Knapp,Michael

AU - Noethen,Markus M.

PY - 2012/9

Y1 - 2012/9

N2 - <p>We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft palate (NSCL/P) using data from the two largest genome-wide association studies published to date. We confirmed associations with all previously identified loci and identified six additional susceptibility regions (1p36, 2p21, 3p11.1, 8q21.3, 13q31.1 and 15q22). Analysis of phenotypic variability identified the first specific genetic risk factor for NSCLP (nonsyndromic cleft lip plus palate) (rs8001641; P-NSCLP = 6.51 x 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16).</p>

AB - <p>We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft palate (NSCL/P) using data from the two largest genome-wide association studies published to date. We confirmed associations with all previously identified loci and identified six additional susceptibility regions (1p36, 2p21, 3p11.1, 8q21.3, 13q31.1 and 15q22). Analysis of phenotypic variability identified the first specific genetic risk factor for NSCLP (nonsyndromic cleft lip plus palate) (rs8001641; P-NSCLP = 6.51 x 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16).</p>

UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84864469869&md5=cd72c9b55453962017e8cd267d6a0226

U2 - 10.1038/ng.2360

DO - 10.1038/ng.2360

M1 - Article

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

VL - 44

SP - 968

EP - 971

ER -

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