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Germ cell apoptosis and DNA damage responses

Germ cell apoptosis and DNA damage responses

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Authors

  • Aymeric Bailly
  • Anton Gartner

Research units

Info

Original languageEnglish
Title of host publicationGerm Cell Development in C. elegans
EditorsTim Schedl
Place of publicationNew York
PublisherSpringer
Publication date2013
Pages249-276
Number of pages28
Volume757
ISBN (Electronic)9781461440154
ISBN (Print)9781461440147
DOIs
StatePublished

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer
Volume757
ISSN (Print)0065-2598

Abstract

In the past 12 years, since the first description of C. elegans germ cell apoptosis, this area of research rapidly expanded. It became evident that multiple genetic pathways lead to the apoptotic demise of germ cells. We are only beginning to understand how these pathways that all require the CED-9/Bcl-2, Apaf-1/CED-4 and CED-3 caspase core apoptosis components are regulated. Physiological apoptosis, which likely accounts for the elimination of more than 50% of all germ cells, even in unperturbed conditions, is likely to be required to maintain tissue homeostasis. The best-studied pathways lead to DNA damage-induced germ cell apoptosis in response to a variety of genotoxic stimuli. This apoptosis appears to be regulated similar to DNA damage-induced apoptosis in the mouse germ line and converges on p53 family transcription factors. DNA damage response pathways not only lead to apoptosis induction, but also directly affect DNA repair, and a transient cell cycle arrest of mitotic germ cells. Finally, distinct pathways activate germ cell apoptosis in response to defects in meiotic recombination and meiotic chromosome pairing. © 2013 Springer Science+Business Media New York.

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