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Germ cell apoptosis and DNA damage responses

Germ cell apoptosis and DNA damage responses

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  • Aymeric Bailly
  • Anton Gartner

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Original languageEnglish
Title of host publicationGerm Cell Development in C. elegans
EditorsTim Schedl
Place of publicationNew York
Publication date2013
Number of pages28
ISBN (Electronic)9781461440154
ISBN (Print)9781461440147

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


In the past 12 years, since the first description of C. elegans germ cell apoptosis, this area of research rapidly expanded. It became evident that multiple genetic pathways lead to the apoptotic demise of germ cells. We are only beginning to understand how these pathways that all require the CED-9/Bcl-2, Apaf-1/CED-4 and CED-3 caspase core apoptosis components are regulated. Physiological apoptosis, which likely accounts for the elimination of more than 50% of all germ cells, even in unperturbed conditions, is likely to be required to maintain tissue homeostasis. The best-studied pathways lead to DNA damage-induced germ cell apoptosis in response to a variety of genotoxic stimuli. This apoptosis appears to be regulated similar to DNA damage-induced apoptosis in the mouse germ line and converges on p53 family transcription factors. DNA damage response pathways not only lead to apoptosis induction, but also directly affect DNA repair, and a transient cell cycle arrest of mitotic germ cells. Finally, distinct pathways activate germ cell apoptosis in response to defects in meiotic recombination and meiotic chromosome pairing. © 2013 Springer Science+Business Media New York.

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