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Glucosinolates and isothiocyanates in health and disease

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Glucosinolates and isothiocyanates in health and disease. / Dinkova-Kostova, Albena T.; Kostov, Rumen V.

In: Trends in Molecular Medicine, Vol. 18, No. 6, 2012, p. 337-347.

Research output: Contribution to journalArticle

Harvard

Dinkova-Kostova, AT & Kostov, RV 2012, 'Glucosinolates and isothiocyanates in health and disease' Trends in Molecular Medicine, vol 18, no. 6, pp. 337-347., 10.1016/j.molmed.2012.04.003

APA

Dinkova-Kostova, A. T., & Kostov, R. V. (2012). Glucosinolates and isothiocyanates in health and disease. Trends in Molecular Medicine, 18(6), 337-347. 10.1016/j.molmed.2012.04.003

Vancouver

Dinkova-Kostova AT, Kostov RV. Glucosinolates and isothiocyanates in health and disease. Trends in Molecular Medicine. 2012;18(6):337-347. Available from: 10.1016/j.molmed.2012.04.003

Author

Dinkova-Kostova, Albena T.; Kostov, Rumen V. / Glucosinolates and isothiocyanates in health and disease.

In: Trends in Molecular Medicine, Vol. 18, No. 6, 2012, p. 337-347.

Research output: Contribution to journalArticle

Bibtex - Download

@article{733255bd953648d6be2c5f405b253ed3,
title = "Glucosinolates and isothiocyanates in health and disease",
author = "Dinkova-Kostova, {Albena T.} and Kostov, {Rumen V.}",
year = "2012",
doi = "10.1016/j.molmed.2012.04.003",
volume = "18",
number = "6",
pages = "337--347",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Glucosinolates and isothiocyanates in health and disease

A1 - Dinkova-Kostova,Albena T.

A1 - Kostov,Rumen V.

AU - Dinkova-Kostova,Albena T.

AU - Kostov,Rumen V.

PY - 2012

Y1 - 2012

N2 - Glucosinolates and isothiocyanates have both been objects of research for more than half a century. Interest in these unique phytochemicals escalated following the discovery that sulforaphane, an isothiocyanate from broccoli, potently induces mammalian cytoprotective proteins through the Keap1-Nrf2-ARE pathway. In parallel with the advances in understanding the molecular regulation of this pathway and its critical role in protection against electrophiles and oxidants, there have been increased efforts toward translating this knowledge to improve human health and combat disease. This review focuses on the animal studies demonstrating the beneficial effects of glucosinolates and isothiocyanates in models of carcinogenesis, and cardiovascular and neurological diseases, as well as on the intervention studies of their safety, pharmacokinetics, and efficacy in humans. © 2012 Elsevier Ltd.

AB - Glucosinolates and isothiocyanates have both been objects of research for more than half a century. Interest in these unique phytochemicals escalated following the discovery that sulforaphane, an isothiocyanate from broccoli, potently induces mammalian cytoprotective proteins through the Keap1-Nrf2-ARE pathway. In parallel with the advances in understanding the molecular regulation of this pathway and its critical role in protection against electrophiles and oxidants, there have been increased efforts toward translating this knowledge to improve human health and combat disease. This review focuses on the animal studies demonstrating the beneficial effects of glucosinolates and isothiocyanates in models of carcinogenesis, and cardiovascular and neurological diseases, as well as on the intervention studies of their safety, pharmacokinetics, and efficacy in humans. © 2012 Elsevier Ltd.

UR - http://www.scopus.com/inward/record.url?scp=84861875282&partnerID=8YFLogxK

U2 - 10.1016/j.molmed.2012.04.003

DO - 10.1016/j.molmed.2012.04.003

M1 - Article

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 6

VL - 18

SP - 337

EP - 347

ER -

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