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Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy

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Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy. / Smith, Gillian; Weidlich, Simone; Dawe, Robert S.; Ibbotson, Sally H.

In: Pharmacogenetics and Genomics, Vol. 21, No. 4, 04.2011, p. 217-224.

Research output: Contribution to journalArticle

Harvard

Smith, G, Weidlich, S, Dawe, RS & Ibbotson, SH 2011, 'Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy' Pharmacogenetics and Genomics, vol 21, no. 4, pp. 217-224., 10.1097/FPC.0b013e32833efb36

APA

Smith, G., Weidlich, S., Dawe, R. S., & Ibbotson, S. H. (2011). Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy. Pharmacogenetics and Genomics, 21(4), 217-224. 10.1097/FPC.0b013e32833efb36

Vancouver

Smith G, Weidlich S, Dawe RS, Ibbotson SH. Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy. Pharmacogenetics and Genomics. 2011 Apr;21(4):217-224. Available from: 10.1097/FPC.0b013e32833efb36

Author

Smith, Gillian; Weidlich, Simone; Dawe, Robert S.; Ibbotson, Sally H. / Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy.

In: Pharmacogenetics and Genomics, Vol. 21, No. 4, 04.2011, p. 217-224.

Research output: Contribution to journalArticle

Bibtex - Download

@article{f4ca8b52ea2341468a676cae80d74499,
title = "Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy",
keywords = "erythema, genotype, GSTM1, GSTT1, MC1R, phototherapy, polymorphism, TL-01, ultraviolet radiation, NONMELANOMA SKIN-CANCER, ULTRAVIOLET-B PHOTOTHERAPY, CUTANEOUS MALIGNANT-MELANOMA, RENAL-TRANSPLANT RECIPIENTS, POLYMERASE-CHAIN-REACTION, CHRONIC PLAQUE PSORIASIS, BASAL-CELL CARCINOMAS, GENE POLYMORPHISMS, DNA-DAMAGE, MELANOCORTIN-1 RECEPTOR",
author = "Gillian Smith and Simone Weidlich and Dawe, {Robert S.} and Ibbotson, {Sally H.}",
year = "2011",
doi = "10.1097/FPC.0b013e32833efb36",
volume = "21",
number = "4",
pages = "217--224",
journal = "Pharmacogenetics and Genomics",
issn = "1744-6872",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy

A1 - Smith,Gillian

A1 - Weidlich,Simone

A1 - Dawe,Robert S.

A1 - Ibbotson,Sally H.

AU - Smith,Gillian

AU - Weidlich,Simone

AU - Dawe,Robert S.

AU - Ibbotson,Sally H.

PY - 2011/4

Y1 - 2011/4

N2 - <p>Objectives Although a majority of psoriasis patients respond to treatment with narrow band ultraviolet B radiation (TL-01) phototherapy, it is currently not possible to predict erythemal sensitivity, or to identify treatment responders. A variety of antioxidant enzymes, including the polymorphic glutathione S-transferase GSTM1 and GSTT1 genes, protect the cell from UVR-induced oxidative challenge. GSTM1 and GSTT1 are deleted in approximately 50 and 20% of the Caucasian population, respectively, and GST null genotype has been associated with increased sunburn sensitivity and reduced minimal erythemal dose (MED) after broadband UVR exposure in healthy volunteers and with susceptibility to skin cancer. Another polymorphic determinant of UVR sensitivity is the melanocortin 1 receptor (MC1R), which protects cells from UVR-induced apoptosis and photodamage. Our aim was therefore to investigate whether GST or MC1R genotype influenced erythemal sensitivity to narrow band (TL-01) ultraviolet B radiation phototherapy in patients with psoriasis.</p><p>Methods We used TaqMan quantitative gene copy and allelic discrimination assays to determine GST and MC1R genotypes, and looked for possible associations between genotype and threshold erythemal sensitivity (MED) and treatment outcomes in patients with psoriasis (n=256).</p><p>Results We showed that GSTM1 genotype, but not GSTT1 or MC1R genotype influences erythemal sensitivity to TL-01 phototherapy, with a significantly lower MED observed in GSTM1 null individuals [chi(2)(2 d.f.) = 8.862, P = 0.012]. None of the genotypes studied were associated with TL-01 treatment outcomes or relapse rates.</p><p>Conclusion GSTM1 genotype may have clinical utility in the prediction of photosensitivity and/or in identifying patients at increased risk of treatment-related side effects. Pharmacogenetics and Genomics 21: 217-224 (C) 2011 Wolters Kluwer Health | Lippincott Williams &amp; Wilkins.</p>

AB - <p>Objectives Although a majority of psoriasis patients respond to treatment with narrow band ultraviolet B radiation (TL-01) phototherapy, it is currently not possible to predict erythemal sensitivity, or to identify treatment responders. A variety of antioxidant enzymes, including the polymorphic glutathione S-transferase GSTM1 and GSTT1 genes, protect the cell from UVR-induced oxidative challenge. GSTM1 and GSTT1 are deleted in approximately 50 and 20% of the Caucasian population, respectively, and GST null genotype has been associated with increased sunburn sensitivity and reduced minimal erythemal dose (MED) after broadband UVR exposure in healthy volunteers and with susceptibility to skin cancer. Another polymorphic determinant of UVR sensitivity is the melanocortin 1 receptor (MC1R), which protects cells from UVR-induced apoptosis and photodamage. Our aim was therefore to investigate whether GST or MC1R genotype influenced erythemal sensitivity to narrow band (TL-01) ultraviolet B radiation phototherapy in patients with psoriasis.</p><p>Methods We used TaqMan quantitative gene copy and allelic discrimination assays to determine GST and MC1R genotypes, and looked for possible associations between genotype and threshold erythemal sensitivity (MED) and treatment outcomes in patients with psoriasis (n=256).</p><p>Results We showed that GSTM1 genotype, but not GSTT1 or MC1R genotype influences erythemal sensitivity to TL-01 phototherapy, with a significantly lower MED observed in GSTM1 null individuals [chi(2)(2 d.f.) = 8.862, P = 0.012]. None of the genotypes studied were associated with TL-01 treatment outcomes or relapse rates.</p><p>Conclusion GSTM1 genotype may have clinical utility in the prediction of photosensitivity and/or in identifying patients at increased risk of treatment-related side effects. Pharmacogenetics and Genomics 21: 217-224 (C) 2011 Wolters Kluwer Health | Lippincott Williams &amp; Wilkins.</p>

KW - erythema

KW - genotype

KW - GSTM1

KW - GSTT1

KW - MC1R

KW - phototherapy

KW - polymorphism

KW - TL-01

KW - ultraviolet radiation

KW - NONMELANOMA SKIN-CANCER

KW - ULTRAVIOLET-B PHOTOTHERAPY

KW - CUTANEOUS MALIGNANT-MELANOMA

KW - RENAL-TRANSPLANT RECIPIENTS

KW - POLYMERASE-CHAIN-REACTION

KW - CHRONIC PLAQUE PSORIASIS

KW - BASAL-CELL CARCINOMAS

KW - GENE POLYMORPHISMS

KW - DNA-DAMAGE

KW - MELANOCORTIN-1 RECEPTOR

U2 - 10.1097/FPC.0b013e32833efb36

DO - 10.1097/FPC.0b013e32833efb36

M1 - Article

JO - Pharmacogenetics and Genomics

JF - Pharmacogenetics and Genomics

SN - 1744-6872

IS - 4

VL - 21

SP - 217

EP - 224

ER -

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