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Heritability of chronic pain in 2195 extended families

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Heritability of chronic pain in 2195 extended families. / Hocking, L J (Lead / Corresponding author); Morris, A D; Dominiczak, A F; Porteous, D J; Smith, B H (Lead / Corresponding author); Generation Scotland.

In: European Journal of Pain, Vol. 16, No. 7, 08.2012, p. 1053-1063.

Research output: Contribution to journalArticle

Harvard

Hocking, LJ, Morris, AD, Dominiczak, AF, Porteous, DJ, Smith, BH & Generation Scotland 2012, 'Heritability of chronic pain in 2195 extended families' European Journal of Pain, vol 16, no. 7, pp. 1053-1063.

APA

Hocking, L. J., Morris, A. D., Dominiczak, A. F., Porteous, D. J., Smith, B. H., & Generation Scotland (2012). Heritability of chronic pain in 2195 extended families. European Journal of Pain, 16(7), 1053-1063doi: 10.1002/j.1532-2149.2011.00095.x

Vancouver

Hocking LJ, Morris AD, Dominiczak AF, Porteous DJ, Smith BH, Generation Scotland. Heritability of chronic pain in 2195 extended families. European Journal of Pain. 2012 Aug;16(7):1053-1063.

Author

Hocking, L J (Lead / Corresponding author); Morris, A D; Dominiczak, A F; Porteous, D J; Smith, B H (Lead / Corresponding author); Generation Scotland / Heritability of chronic pain in 2195 extended families.

In: European Journal of Pain, Vol. 16, No. 7, 08.2012, p. 1053-1063.

Research output: Contribution to journalArticle

Bibtex - Download

@article{5d3fa13339f741b0b55a007f54284e62,
title = "Heritability of chronic pain in 2195 extended families",
author = "Hocking, {L J} and Morris, {A D} and Dominiczak, {A F} and Porteous, {D J} and Smith, {B H} and {Generation Scotland}",
year = "2012",
volume = "16",
number = "7",
pages = "1053--1063",
journal = "European Journal of Pain",
issn = "1090-3801",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Heritability of chronic pain in 2195 extended families

A1 - Hocking,L J

A1 - Morris,A D

A1 - Dominiczak,A F

A1 - Porteous,D J

A1 - Smith,B H

A1 - Generation Scotland

AU - Hocking,L J

AU - Morris,A D

AU - Dominiczak,A F

AU - Porteous,D J

AU - Smith,B H

AU - Generation Scotland

PY - 2012/8

Y1 - 2012/8

N2 - Chronic pain is pathological, persisting beyond normal tissue healing time. Previous work has suggested ~50% variation in chronic pain development is heritable. No data are currently available on the heritability of pain categorized using the Chronic Pain Grade (CPG). Furthermore, few existing studies have accounted for potential confounders that may themselves be under genetic control or indeed 'heritable' non-genetic traits. This study aimed to determine the relative contributions of genetic, measured and shared environmental and lifestyle factors to chronic pain. Chronic pain status was determined and CPG measured in participants from Generation Scotland: the Scottish Family Health Study, a large cohort of well-characterized, extended families from throughout Scotland, UK. Heritability estimates (h (2) ) for 'any chronic pain' and 'severe' chronic pain (CPG 3 or 4) were generated using SOLAR software, with and without adjustment for shared household effects and measured covariates age, body mass index, gender, household income, occupation and physical activity. Data were available for 7644 individuals in 2195 extended families. Without adjustment, h (2) for 'any chronic pain' was 29% [standard errors (SE) 6%; p?

AB - Chronic pain is pathological, persisting beyond normal tissue healing time. Previous work has suggested ~50% variation in chronic pain development is heritable. No data are currently available on the heritability of pain categorized using the Chronic Pain Grade (CPG). Furthermore, few existing studies have accounted for potential confounders that may themselves be under genetic control or indeed 'heritable' non-genetic traits. This study aimed to determine the relative contributions of genetic, measured and shared environmental and lifestyle factors to chronic pain. Chronic pain status was determined and CPG measured in participants from Generation Scotland: the Scottish Family Health Study, a large cohort of well-characterized, extended families from throughout Scotland, UK. Heritability estimates (h (2) ) for 'any chronic pain' and 'severe' chronic pain (CPG 3 or 4) were generated using SOLAR software, with and without adjustment for shared household effects and measured covariates age, body mass index, gender, household income, occupation and physical activity. Data were available for 7644 individuals in 2195 extended families. Without adjustment, h (2) for 'any chronic pain' was 29% [standard errors (SE) 6%; p?

U2 - 10.1002/j.1532-2149.2011.00095.x

DO - 10.1002/j.1532-2149.2011.00095.x

M1 - Article

JO - European Journal of Pain

JF - European Journal of Pain

SN - 1090-3801

IS - 7

VL - 16

SP - 1053

EP - 1063

ER -

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