Discovery - University of Dundee - Online Publications

Library & Learning Centre

High frequency of complex TP53 mutations in CNS metastases from breast cancer

Standard

High frequency of complex TP53 mutations in CNS metastases from breast cancer. / Lo Nigro, C.; Vivenza, D.; Monteverde, M.; Lattanzio, L.; Gojis, O.; Garrone, O.; Comino, A.; Merlano, M.; Quinlan, P.R.; Syed, N.; Purdie, C. A. ; Thompson, A.; Palmieri, C.; Crook, T.

In: British Journal of Cancer, Vol. 106, No. 2, 17.01.2012, p. 397-404.

Research output: Contribution to journalArticle

Harvard

Lo Nigro, C, Vivenza, D, Monteverde, M, Lattanzio, L, Gojis, O, Garrone, O, Comino, A, Merlano, M, Quinlan, PR, Syed, N, Purdie, CA, Thompson, A, Palmieri, C & Crook, T 2012, 'High frequency of complex TP53 mutations in CNS metastases from breast cancer' British Journal of Cancer, vol 106, no. 2, pp. 397-404., 10.1038/bjc.2011.464

APA

Lo Nigro, C., Vivenza, D., Monteverde, M., Lattanzio, L., Gojis, O., Garrone, O., ... Crook, T. (2012). High frequency of complex TP53 mutations in CNS metastases from breast cancer. British Journal of Cancer, 106(2), 397-404. 10.1038/bjc.2011.464

Vancouver

Lo Nigro C, Vivenza D, Monteverde M, Lattanzio L, Gojis O, Garrone O et al. High frequency of complex TP53 mutations in CNS metastases from breast cancer. British Journal of Cancer. 2012 Jan 17;106(2):397-404. Available from: 10.1038/bjc.2011.464

Author

Lo Nigro, C.; Vivenza, D.; Monteverde, M.; Lattanzio, L.; Gojis, O.; Garrone, O.; Comino, A.; Merlano, M.; Quinlan, P.R.; Syed, N.; Purdie, C. A. ; Thompson, A.; Palmieri, C.; Crook, T. / High frequency of complex TP53 mutations in CNS metastases from breast cancer.

In: British Journal of Cancer, Vol. 106, No. 2, 17.01.2012, p. 397-404.

Research output: Contribution to journalArticle

Bibtex - Download

@article{b17deaec9b544513af9282021f2e50ad,
title = "High frequency of complex TP53 mutations in CNS metastases from breast cancer",
keywords = "breast cancer, CNS metastasis, p53, triple-negative breast cancer, P53 MUTATIONS, TUMORS, PROGNOSIS, GENES, BRAIN",
author = "{Lo Nigro}, C. and D. Vivenza and M. Monteverde and L. Lattanzio and O. Gojis and O. Garrone and A. Comino and M. Merlano and P.R. Quinlan and N. Syed and Purdie, {C. A.} and A. Thompson and C. Palmieri and T. Crook",
year = "2012",
doi = "10.1038/bjc.2011.464",
volume = "106",
number = "2",
pages = "397--404",
journal = "British Journal of Cancer",
issn = "0007-0920",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - High frequency of complex TP53 mutations in CNS metastases from breast cancer

A1 - Lo Nigro,C.

A1 - Vivenza,D.

A1 - Monteverde,M.

A1 - Lattanzio,L.

A1 - Gojis,O.

A1 - Garrone,O.

A1 - Comino,A.

A1 - Merlano,M.

A1 - Quinlan,P.R.

A1 - Syed,N.

A1 - Purdie,C. A.

A1 - Thompson,A.

A1 - Palmieri,C.

A1 - Crook,T.

AU - Lo Nigro,C.

AU - Vivenza,D.

AU - Monteverde,M.

AU - Lattanzio,L.

AU - Gojis,O.

AU - Garrone,O.

AU - Comino,A.

AU - Merlano,M.

AU - Quinlan,P.R.

AU - Syed,N.

AU - Purdie,C. A.

AU - Thompson,A.

AU - Palmieri,C.

AU - Crook,T.

PY - 2012/1/17

Y1 - 2012/1/17

N2 - <p>BACKGROUND: Brain metastasis from breast cancer is usually associated with a poor prognosis and early death. Alteration of p53 may contribute to malignant progression by abrogation of apoptosis induced by oncogene activation and by acquisition of gain-of-function properties, which promote tumour aggression. Mutation in TP53 occurs at high frequency in carcinomas of the lung and gastrointestinal tract, but is much less frequent, at 25%, in primary breast cancer. The frequency of TP53 alteration in the central nervous system (CNS) metastatic breast cancer is not known.</p><p>METHODS: In all, 23 cases of histologically confirmed CNS metastatic breast cancer were identified and the coding sequence of TP53 determined. TP53 was also sequenced in two control series of primary breast carcinomas from independent clinical centres.</p><p>RESULTS: We demonstrate a strikingly high frequency of TP53 mutation in the CNS metastatic lesions with an over-representation of complex mutations (non-sense/deletions/insertions). Complex mutations occur in metastatic lesions in both triple-negative breast cancer and hormone receptor/HER2-positive cases. Analysis of paired primary carcinomas and brain metastatic lesions revealed evidence for both clonal selection and generation of new mutations (missense and complex) in progression from a primary breast carcinoma to brain metastasis.</p><p>CONCLUSION: Mutation in TP53 is the most common genetic alteration reported during metastasis to the brain in breast cancer. British Journal of Cancer (2012) 106, 397-404. doi:10.1038/bjc.2011.464 www.bjcancer.com Published online 20 December 2011 (C) 2012 Cancer Research UK</p>

AB - <p>BACKGROUND: Brain metastasis from breast cancer is usually associated with a poor prognosis and early death. Alteration of p53 may contribute to malignant progression by abrogation of apoptosis induced by oncogene activation and by acquisition of gain-of-function properties, which promote tumour aggression. Mutation in TP53 occurs at high frequency in carcinomas of the lung and gastrointestinal tract, but is much less frequent, at 25%, in primary breast cancer. The frequency of TP53 alteration in the central nervous system (CNS) metastatic breast cancer is not known.</p><p>METHODS: In all, 23 cases of histologically confirmed CNS metastatic breast cancer were identified and the coding sequence of TP53 determined. TP53 was also sequenced in two control series of primary breast carcinomas from independent clinical centres.</p><p>RESULTS: We demonstrate a strikingly high frequency of TP53 mutation in the CNS metastatic lesions with an over-representation of complex mutations (non-sense/deletions/insertions). Complex mutations occur in metastatic lesions in both triple-negative breast cancer and hormone receptor/HER2-positive cases. Analysis of paired primary carcinomas and brain metastatic lesions revealed evidence for both clonal selection and generation of new mutations (missense and complex) in progression from a primary breast carcinoma to brain metastasis.</p><p>CONCLUSION: Mutation in TP53 is the most common genetic alteration reported during metastasis to the brain in breast cancer. British Journal of Cancer (2012) 106, 397-404. doi:10.1038/bjc.2011.464 www.bjcancer.com Published online 20 December 2011 (C) 2012 Cancer Research UK</p>

KW - breast cancer

KW - CNS metastasis

KW - p53

KW - triple-negative breast cancer

KW - P53 MUTATIONS

KW - TUMORS

KW - PROGNOSIS

KW - GENES

KW - BRAIN

U2 - 10.1038/bjc.2011.464

DO - 10.1038/bjc.2011.464

M1 - Article

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 2

VL - 106

SP - 397

EP - 404

ER -

Documents

Library & Learning Centre

Contact | Accessibility | Policy