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High-affinity fluorescent ligands for the 5-HT3 receptor

High-affinity fluorescent ligands for the 5-HT3 receptor

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Authors

  • Jonathan Simonin
  • Sanjeev Kumar V. Vernekar
  • Andrew J. Thompson
  • J. Daniel Hothersall
  • Christopher N. Connolly
  • Sarah C. R. Lummis
  • Martin Lochner

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Info

Original languageEnglish
Pages1151-1155
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Journal publication date2012
Volume22
Issue2
DOIs
StatePublished

Abstract

The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT3 receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR. (C) 2011 Elsevier Ltd. All rights reserved.

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