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Human box C/D snoRNA processing conservation across multiple cell types

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Human box C/D snoRNA processing conservation across multiple cell types. / Scott, Michelle S.; Ono, Motoharu; Yamada, Kayo; Endo, Akinori; Barton, Geoffrey J.; Lamond, Angus I.

In: Nucleic Acids Research, Vol. 40, No. 8, 04.2012, p. 3676-3688.

Research output: Contribution to journalArticle

Harvard

Scott, MS, Ono, M, Yamada, K, Endo, A, Barton, GJ & Lamond, AI 2012, 'Human box C/D snoRNA processing conservation across multiple cell types' Nucleic Acids Research, vol 40, no. 8, pp. 3676-3688.

APA

Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J., & Lamond, A. I. (2012). Human box C/D snoRNA processing conservation across multiple cell types. Nucleic Acids Research, 40(8), 3676-3688doi: 10.1093/nar/gkr1233

Vancouver

Scott MS, Ono M, Yamada K, Endo A, Barton GJ, Lamond AI. Human box C/D snoRNA processing conservation across multiple cell types. Nucleic Acids Research. 2012 Apr;40(8):3676-3688.

Author

Scott, Michelle S.; Ono, Motoharu; Yamada, Kayo; Endo, Akinori; Barton, Geoffrey J.; Lamond, Angus I. / Human box C/D snoRNA processing conservation across multiple cell types.

In: Nucleic Acids Research, Vol. 40, No. 8, 04.2012, p. 3676-3688.

Research output: Contribution to journalArticle

Bibtex - Download

@article{21e09b97c6024780b9ec057759363461,
title = "Human box C/D snoRNA processing conservation across multiple cell types",
author = "Scott, {Michelle S.} and Motoharu Ono and Kayo Yamada and Akinori Endo and Barton, {Geoffrey J.} and Lamond, {Angus I.}",
year = "2012",
volume = "40",
number = "8",
pages = "3676--3688",
journal = "Nucleic Acids Research",
issn = "0305-1048",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Human box C/D snoRNA processing conservation across multiple cell types

A1 - Scott,Michelle S.

A1 - Ono,Motoharu

A1 - Yamada,Kayo

A1 - Endo,Akinori

A1 - Barton,Geoffrey J.

A1 - Lamond,Angus I.

AU - Scott,Michelle S.

AU - Ono,Motoharu

AU - Yamada,Kayo

AU - Endo,Akinori

AU - Barton,Geoffrey J.

AU - Lamond,Angus I.

PY - 2012/4

Y1 - 2012/4

N2 - <p>Small nucleolar RNAs (snoRNAs) function mainly as guides for the post-transcriptional modification of ribosomal RNAs (rRNAs). In recent years, several studies have identified a wealth of small fragments (&lt; 35 nt) derived from snoRNAs (termed sdRNAs) that stably accumulate in the cell, some of which may regulate splicing or translation. A comparison of human small RNA deep sequencing data sets reveals that box C/D sdRNA accumulation patterns are conserved across multiple cell types although the ratio of the abundance of different sdRNAs from a given snoRNA varies. sdRNA profiles of many snoRNAs are specific and resemble the cleavage profiles of miRNAs. Many do not show characteristics of general RNA degradation, as seen for the accumulation of small fragments derived from snRNA or rRNA. While 53% of the sdRNAs contain an snoRNA box C motif and boxes D and D' are also common in sdRNAs (54%), relatively few (12%) contain a full snoRNA guide region. One box C/D snoRNA, HBII-180C, was analysed in greater detail, revealing the presence of C' box-containing sdRNAs complementary to several pre-messenger RNAs (pre-mRNAs) including FGFR3. Functional analyses demonstrated that this region of HBII-180C can influence the alternative splicing of FGFR3 pre-mRNA, supporting a role for some snoRNAs in the regulation of splicing.</p>

AB - <p>Small nucleolar RNAs (snoRNAs) function mainly as guides for the post-transcriptional modification of ribosomal RNAs (rRNAs). In recent years, several studies have identified a wealth of small fragments (&lt; 35 nt) derived from snoRNAs (termed sdRNAs) that stably accumulate in the cell, some of which may regulate splicing or translation. A comparison of human small RNA deep sequencing data sets reveals that box C/D sdRNA accumulation patterns are conserved across multiple cell types although the ratio of the abundance of different sdRNAs from a given snoRNA varies. sdRNA profiles of many snoRNAs are specific and resemble the cleavage profiles of miRNAs. Many do not show characteristics of general RNA degradation, as seen for the accumulation of small fragments derived from snRNA or rRNA. While 53% of the sdRNAs contain an snoRNA box C motif and boxes D and D' are also common in sdRNAs (54%), relatively few (12%) contain a full snoRNA guide region. One box C/D snoRNA, HBII-180C, was analysed in greater detail, revealing the presence of C' box-containing sdRNAs complementary to several pre-messenger RNAs (pre-mRNAs) including FGFR3. Functional analyses demonstrated that this region of HBII-180C can influence the alternative splicing of FGFR3 pre-mRNA, supporting a role for some snoRNAs in the regulation of splicing.</p>

U2 - 10.1093/nar/gkr1233

DO - 10.1093/nar/gkr1233

M1 - Article

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 8

VL - 40

SP - 3676

EP - 3688

ER -

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