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Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application

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Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application. / Hoskins, Clare; Min, Yue; Gueorguieva, Mariana; McDougall, Craig; Volovick, Alexander; Prentice, Paul; Wang, Zhigang; Melzer, Andreas; Cuschieri, Alfred; Wang, Lijun.

In: Journal of nanobiotechnology, Vol. 10, 27, 25.06.2012.

Research output: Contribution to journalArticle

Harvard

Hoskins, C, Min, Y, Gueorguieva, M, McDougall, C, Volovick, A, Prentice, P, Wang, Z, Melzer, A, Cuschieri, A & Wang, L 2012, 'Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application' Journal of nanobiotechnology, vol 10, 27., 10.1186/1477-3155-10-27

APA

Hoskins, C., Min, Y., Gueorguieva, M., McDougall, C., Volovick, A., Prentice, P., ... Wang, L. (2012). Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application. Journal of nanobiotechnology, 10, [27]. 10.1186/1477-3155-10-27

Vancouver

Hoskins C, Min Y, Gueorguieva M, McDougall C, Volovick A, Prentice P et al. Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application. Journal of nanobiotechnology. 2012 Jun 25;10. 27. Available from: 10.1186/1477-3155-10-27

Author

Hoskins, Clare; Min, Yue; Gueorguieva, Mariana; McDougall, Craig; Volovick, Alexander; Prentice, Paul; Wang, Zhigang; Melzer, Andreas; Cuschieri, Alfred; Wang, Lijun / Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application.

In: Journal of nanobiotechnology, Vol. 10, 27, 25.06.2012.

Research output: Contribution to journalArticle

Bibtex - Download

@article{fe6b2dcfad24401da269df74727a293f,
title = "Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application",
keywords = "Magnetic nanoparticles, Gold nano-shells, Magnetic resonance imaging, Surface plasmon resonance, Multifunctional nanoparticles",
author = "Clare Hoskins and Yue Min and Mariana Gueorguieva and Craig McDougall and Alexander Volovick and Paul Prentice and Zhigang Wang and Andreas Melzer and Alfred Cuschieri and Lijun Wang",
year = "2012",
doi = "10.1186/1477-3155-10-27",
volume = "10",
journal = "Journal of nanobiotechnology",
issn = "1477-3155",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application

A1 - Hoskins,Clare

A1 - Min,Yue

A1 - Gueorguieva,Mariana

A1 - McDougall,Craig

A1 - Volovick,Alexander

A1 - Prentice,Paul

A1 - Wang,Zhigang

A1 - Melzer,Andreas

A1 - Cuschieri,Alfred

A1 - Wang,Lijun

AU - Hoskins,Clare

AU - Min,Yue

AU - Gueorguieva,Mariana

AU - McDougall,Craig

AU - Volovick,Alexander

AU - Prentice,Paul

AU - Wang,Zhigang

AU - Melzer,Andreas

AU - Cuschieri,Alfred

AU - Wang,Lijun

PY - 2012/6/25

Y1 - 2012/6/25

N2 - <p>Background: Iron oxide nanoparticles (IONPs) have increasing applications in biomedicine, however fears over long term stability of polymer coated particles have arisen. Gold coating IONPs results in particles of increased stability and robustness. The unique properties of both the iron oxide (magnetic) and gold (surface plasmon resonance) result in a multimodal platform for use as MRI contrast agents and as a nano-heater.</p><p>Results: Here we synthesize IONPs of core diameter 30 nm and gold coat using the seeding method with a poly (ethylenimine) intermediate layer. The final particles were coated in poly(ethylene glycol) to ensure biocompatibility and increase retention times in vivo. The particle coating was monitored using FTIR, PCS, UV-vis absorption, TEM, and EDX. The particles appeared to have little cytotoxic effect when incubated with A375M cells. The resultant hybrid nanoparticles (HNPs) possessed a maximal absorbance at 600 nm. After laser irradiation in agar phantom a Delta T of 32 degrees C was achieved after only 90 s exposure (50 mu gmL(-1)). The HNPs appeared to decrease T-2 values in line with previously clinically used MRI contrast agent Feridex (R).</p><p>Conclusions: The data highlights the potential of these HNPs as dual function MRI contrast agents and nanoheaters for therapies such as cellular hyperthermia or thermo-responsive drug delivery.</p>

AB - <p>Background: Iron oxide nanoparticles (IONPs) have increasing applications in biomedicine, however fears over long term stability of polymer coated particles have arisen. Gold coating IONPs results in particles of increased stability and robustness. The unique properties of both the iron oxide (magnetic) and gold (surface plasmon resonance) result in a multimodal platform for use as MRI contrast agents and as a nano-heater.</p><p>Results: Here we synthesize IONPs of core diameter 30 nm and gold coat using the seeding method with a poly (ethylenimine) intermediate layer. The final particles were coated in poly(ethylene glycol) to ensure biocompatibility and increase retention times in vivo. The particle coating was monitored using FTIR, PCS, UV-vis absorption, TEM, and EDX. The particles appeared to have little cytotoxic effect when incubated with A375M cells. The resultant hybrid nanoparticles (HNPs) possessed a maximal absorbance at 600 nm. After laser irradiation in agar phantom a Delta T of 32 degrees C was achieved after only 90 s exposure (50 mu gmL(-1)). The HNPs appeared to decrease T-2 values in line with previously clinically used MRI contrast agent Feridex (R).</p><p>Conclusions: The data highlights the potential of these HNPs as dual function MRI contrast agents and nanoheaters for therapies such as cellular hyperthermia or thermo-responsive drug delivery.</p>

KW - Magnetic nanoparticles

KW - Gold nano-shells

KW - Magnetic resonance imaging

KW - Surface plasmon resonance

KW - Multifunctional nanoparticles

U2 - 10.1186/1477-3155-10-27

DO - 10.1186/1477-3155-10-27

M1 - Article

JO - Journal of nanobiotechnology

JF - Journal of nanobiotechnology

SN - 1477-3155

VL - 10

ER -

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