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Identification of human miRNA precursors that resemble box C/D snoRNAs

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Identification of human miRNA precursors that resemble box C/D snoRNAs. / Ono, Motoharu; Scott, Michelle S.; Yamada, Kayo; Avolio, Fabio; Barton, Geoffrey J.; Lamond, Angus I.

In: Nucleic Acids Research, Vol. 39, No. 9, 05.2011, p. 3879-3891.

Research output: Contribution to journalArticle

Harvard

Ono, M, Scott, MS, Yamada, K, Avolio, F, Barton, GJ & Lamond, AI 2011, 'Identification of human miRNA precursors that resemble box C/D snoRNAs' Nucleic Acids Research, vol 39, no. 9, pp. 3879-3891., 10.1093/nar/gkq1355

APA

Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J., & Lamond, A. I. (2011). Identification of human miRNA precursors that resemble box C/D snoRNAs. Nucleic Acids Research, 39(9), 3879-3891. 10.1093/nar/gkq1355

Vancouver

Ono M, Scott MS, Yamada K, Avolio F, Barton GJ, Lamond AI. Identification of human miRNA precursors that resemble box C/D snoRNAs. Nucleic Acids Research. 2011 May;39(9):3879-3891. Available from: 10.1093/nar/gkq1355

Author

Ono, Motoharu; Scott, Michelle S.; Yamada, Kayo; Avolio, Fabio; Barton, Geoffrey J.; Lamond, Angus I. / Identification of human miRNA precursors that resemble box C/D snoRNAs.

In: Nucleic Acids Research, Vol. 39, No. 9, 05.2011, p. 3879-3891.

Research output: Contribution to journalArticle

Bibtex - Download

@article{afdac0f838734914b7b36ad46df52838,
title = "Identification of human miRNA precursors that resemble box C/D snoRNAs",
keywords = "RNA SECONDARY STRUCTURE, SMALL NUCLEOLAR RNAS, HOST GENES, MICRORNAS, NUCLEAR, CANDIDATES, DYNAMICS, REVEALS, MOUSE, CELLS",
author = "Motoharu Ono and Scott, {Michelle S.} and Kayo Yamada and Fabio Avolio and Barton, {Geoffrey J.} and Lamond, {Angus I.}",
year = "2011",
doi = "10.1093/nar/gkq1355",
volume = "39",
number = "9",
pages = "3879--3891",
journal = "Nucleic Acids Research",
issn = "0305-1048",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Identification of human miRNA precursors that resemble box C/D snoRNAs

A1 - Ono,Motoharu

A1 - Scott,Michelle S.

A1 - Yamada,Kayo

A1 - Avolio,Fabio

A1 - Barton,Geoffrey J.

A1 - Lamond,Angus I.

AU - Ono,Motoharu

AU - Scott,Michelle S.

AU - Yamada,Kayo

AU - Avolio,Fabio

AU - Barton,Geoffrey J.

AU - Lamond,Angus I.

PY - 2011/5

Y1 - 2011/5

N2 - <p>There are two main classes of small nucleolar RNAs (snoRNAs): the box C/D snoRNAs and the box H/ACA snoRNAs that function as guide RNAs to direct sequence-specific modification of rRNA precursors and other nucleolar RNA targets. A previous computational and biochemical analysis revealed a possible evolutionary relationship between miRNA precursors and some box H/ACA snoRNAs. Here, we investigate a similar evolutionary relationship between a subset of miRNA precursors and box C/D snoRNAs. Computational analyses identified 84 intronic miRNAs that are encoded within either box C/D snoRNAs, or in precursors showing similarity to box C/D snoRNAs. Predictions of the folded structures of these box C/D snoRNA-like miRNA precursors resemble the structures of known box C/D snoRNAs, with the boxes C and D often in close proximity in the folded molecule. All five box C/D snoRNA-like miRNA precursors tested (miR-27b, miR-16-1, mir-28, miR-31 and let-7g) bind to fibrillarin, a specific protein component of functional box C/D snoRNP complexes. The data suggest that a subset of small regulatory RNAs may have evolved from box C/D snoRNAs.</p>

AB - <p>There are two main classes of small nucleolar RNAs (snoRNAs): the box C/D snoRNAs and the box H/ACA snoRNAs that function as guide RNAs to direct sequence-specific modification of rRNA precursors and other nucleolar RNA targets. A previous computational and biochemical analysis revealed a possible evolutionary relationship between miRNA precursors and some box H/ACA snoRNAs. Here, we investigate a similar evolutionary relationship between a subset of miRNA precursors and box C/D snoRNAs. Computational analyses identified 84 intronic miRNAs that are encoded within either box C/D snoRNAs, or in precursors showing similarity to box C/D snoRNAs. Predictions of the folded structures of these box C/D snoRNA-like miRNA precursors resemble the structures of known box C/D snoRNAs, with the boxes C and D often in close proximity in the folded molecule. All five box C/D snoRNA-like miRNA precursors tested (miR-27b, miR-16-1, mir-28, miR-31 and let-7g) bind to fibrillarin, a specific protein component of functional box C/D snoRNP complexes. The data suggest that a subset of small regulatory RNAs may have evolved from box C/D snoRNAs.</p>

KW - RNA SECONDARY STRUCTURE

KW - SMALL NUCLEOLAR RNAS

KW - HOST GENES

KW - MICRORNAS

KW - NUCLEAR

KW - CANDIDATES

KW - DYNAMICS

KW - REVEALS

KW - MOUSE

KW - CELLS

U2 - 10.1093/nar/gkq1355

DO - 10.1093/nar/gkq1355

M1 - Article

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 9

VL - 39

SP - 3879

EP - 3891

ER -

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