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Influence of waveform on cell viability during ultrasound exposure

Influence of waveform on cell viability during ultrasound exposure

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Info

Original languageEnglish
Title10th International Symposium on Therapeutic Ultrasound
SubtitleISTU 2010
EditorsY Matsumoto, LA Crum, GR TerHaar
Place of publicationMelville
PublisherAmerican Institute of Physics
Publication date2011
Pages367-370
Number of pages4
ISBN (Print)9780735409170
DOIs
StatePublished

Conference

Conference10th International Symposium on Therapeutic Ultrasound
CountryJapan
CityTokyo
Period9/06/1012/06/10
Internet addresshttp://www.fel.t.u-tokyo.ac.jp/istu/

Abstract

We examined the role of ultrasound standing waves, and their travelling wave counterparts, on cell viability in an in-vitro insonation apparatus. Furthermore, the effect of distinct waveforms (sine and top-hat) was also explored, together with the role of microbubble presence. Measurements of cell viability in standing wave scenarios demonstrated a relatively higher rate of lysis (63.13 +/- 10.89% remaining viable) compared with the travelling wave data, where 96.22 +/- 4.0% remained viable. Significant differences were also seen as a function of waveform, where insonations employing top-hat wave shapes resulted in an average end stage viability of 30.31 +/- 5.71 % compared with 61.94 +/- 14.28% in the sinusoidal counterparts.

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