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Influence of waveform on cell viability during ultrasound exposure

Influence of waveform on cell viability during ultrasound exposure

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Original languageEnglish
Title of host publication10th International Symposium on Therapeutic Ultrasound
Subtitle of host publicationISTU 2010
EditorsY Matsumoto, LA Crum, GR TerHaar
Place of PublicationMelville
PublisherAmerican Institute of Physics
Number of pages4
ISBN (Print)9780735409170
StatePublished - 2011


Conference10th International Symposium on Therapeutic Ultrasound
Abbreviated titleISTU 2010
Internet address


We examined the role of ultrasound standing waves, and their travelling wave counterparts, on cell viability in an in-vitro insonation apparatus. Furthermore, the effect of distinct waveforms (sine and top-hat) was also explored, together with the role of microbubble presence. Measurements of cell viability in standing wave scenarios demonstrated a relatively higher rate of lysis (63.13 +/- 10.89% remaining viable) compared with the travelling wave data, where 96.22 +/- 4.0% remained viable. Significant differences were also seen as a function of waveform, where insonations employing top-hat wave shapes resulted in an average end stage viability of 30.31 +/- 5.71 % compared with 61.94 +/- 14.28% in the sinusoidal counterparts.



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