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Influence of waveform on cell viability during ultrasound exposure

Influence of waveform on cell viability during ultrasound exposure

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Authors

  • Timur Saliev
  • Loreto B. Feril
  • Donald A. McLean
  • Katsuro Tachibana
  • Paul A. Campbell

Research units

Info

Original languageEnglish
Title of host publication10th International Symposium on Therapeutic Ultrasound
Subtitle of host publicationISTU 2010
EditorsY Matsumoto, LA Crum, GR TerHaar
Place of PublicationMelville
PublisherAmerican Institute of Physics
Pages367-370
Number of pages4
ISBN (Print)9780735409170
DOIs
StatePublished - 2011
Event10th International Symposium on Therapeutic Ultrasound - Tokyo, Japan

Conference

Conference10th International Symposium on Therapeutic Ultrasound
Abbreviated titleISTU 2010
CountryJapan
CityTokyo
Period9/06/1012/06/10
Internet address

Abstract

We examined the role of ultrasound standing waves, and their travelling wave counterparts, on cell viability in an in-vitro insonation apparatus. Furthermore, the effect of distinct waveforms (sine and top-hat) was also explored, together with the role of microbubble presence. Measurements of cell viability in standing wave scenarios demonstrated a relatively higher rate of lysis (63.13 +/- 10.89% remaining viable) compared with the travelling wave data, where 96.22 +/- 4.0% remained viable. Significant differences were also seen as a function of waveform, where insonations employing top-hat wave shapes resulted in an average end stage viability of 30.31 +/- 5.71 % compared with 61.94 +/- 14.28% in the sinusoidal counterparts.

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