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Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α

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Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α. / Terrier, Olivier (Lead / Corresponding author); Marcel, Virginie; Cartet, Gaelle; Lane, David P.; Lina, Bruno; Rosa-Calatrava, Manuel; Bourdon, Jean-Christophe (Lead / Corresponding author).

In: Journal of Virology, Vol. 86, No. 16, 08.2012, p. 8452-8460.

Research output: Contribution to journalArticle

Harvard

Terrier, O, Marcel, V, Cartet, G, Lane, DP, Lina, B, Rosa-Calatrava, M & Bourdon, J-C 2012, 'Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α' Journal of Virology, vol 86, no. 16, pp. 8452-8460., 10.1128/JVI.07143-11

APA

Terrier, O., Marcel, V., Cartet, G., Lane, D. P., Lina, B., Rosa-Calatrava, M., & Bourdon, J-C. (2012). Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α. Journal of Virology, 86(16), 8452-8460. 10.1128/JVI.07143-11

Vancouver

Terrier O, Marcel V, Cartet G, Lane DP, Lina B, Rosa-Calatrava M et al. Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α. Journal of Virology. 2012 Aug;86(16):8452-8460. Available from: 10.1128/JVI.07143-11

Author

Terrier, Olivier (Lead / Corresponding author); Marcel, Virginie; Cartet, Gaelle; Lane, David P.; Lina, Bruno; Rosa-Calatrava, Manuel; Bourdon, Jean-Christophe (Lead / Corresponding author) / Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α.

In: Journal of Virology, Vol. 86, No. 16, 08.2012, p. 8452-8460.

Research output: Contribution to journalArticle

Bibtex - Download

@article{f50b0824a8424bf486d42ef8b36fa2af,
title = "Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α",
author = "Olivier Terrier and Virginie Marcel and Gaelle Cartet and Lane, {David P.} and Bruno Lina and Manuel Rosa-Calatrava and Jean-Christophe Bourdon",
year = "2012",
doi = "10.1128/JVI.07143-11",
volume = "86",
number = "16",
pages = "8452--8460",
journal = "Journal of Virology",
issn = "0022-538X",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α

A1 - Terrier,Olivier

A1 - Marcel,Virginie

A1 - Cartet,Gaelle

A1 - Lane,David P.

A1 - Lina,Bruno

A1 - Rosa-Calatrava,Manuel

A1 - Bourdon,Jean-Christophe

AU - Terrier,Olivier

AU - Marcel,Virginie

AU - Cartet,Gaelle

AU - Lane,David P.

AU - Lina,Bruno

AU - Rosa-Calatrava,Manuel

AU - Bourdon,Jean-Christophe

PY - 2012/8

Y1 - 2012/8

N2 - <p>Previous studies have described the role of p53 isoforms, including p53 beta and Delta 133p53 alpha, in the modulation of the activity of full-length p53, which regulates cell fate. In the context of influenza virus infection, an interplay between influenza viruses and p53 has been described, with p53 being involved in the antiviral response. However, the role of physiological p53 isoforms has never been explored in this context. Here, we demonstrate that p53 isoforms play a role in influenza A virus infection by using silencing and transient expression strategies in human lung epithelial cells. In addition, with the help of a panel of different influenza viruses from different subtypes, we also show that infection differentially regulates the expressions of p53 beta and Delta 133p53 alpha. Altogether, our results highlight the role of p53 isoforms in the viral cycle of influenza A viruses, with p53 beta and Delta 133p53 alpha acting as regulators of viral production in a p53-dependent manner.</p>

AB - <p>Previous studies have described the role of p53 isoforms, including p53 beta and Delta 133p53 alpha, in the modulation of the activity of full-length p53, which regulates cell fate. In the context of influenza virus infection, an interplay between influenza viruses and p53 has been described, with p53 being involved in the antiviral response. However, the role of physiological p53 isoforms has never been explored in this context. Here, we demonstrate that p53 isoforms play a role in influenza A virus infection by using silencing and transient expression strategies in human lung epithelial cells. In addition, with the help of a panel of different influenza viruses from different subtypes, we also show that infection differentially regulates the expressions of p53 beta and Delta 133p53 alpha. Altogether, our results highlight the role of p53 isoforms in the viral cycle of influenza A viruses, with p53 beta and Delta 133p53 alpha acting as regulators of viral production in a p53-dependent manner.</p>

UR - http://www.scopus.com/inward/record.url?scp=84865076768&partnerID=8YFLogxK

U2 - 10.1128/JVI.07143-11

DO - 10.1128/JVI.07143-11

M1 - Article

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 16

VL - 86

SP - 8452

EP - 8460

ER -

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