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Inhaled and Systemic Corticosteroid Response in Severe Asthma Assessed by Alveolar Nitric Oxide

Inhaled and Systemic Corticosteroid Response in Severe Asthma Assessed by Alveolar Nitric Oxide : a randomised crossover pilot study of add-on therapy

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Original languageEnglish
Pages93-102
Number of pages10
JournalBritish Journal of Clinical Pharmacology
Journal publication dateJan 2013
Journal number1
Volume75
DOIs
StatePublished

Abstract

Aims: Alveolar nitric oxide (CA(NO) ) is a potential biomarker of small airway inflammation. We investigated effects on CA(NO) of the addition of coarse and fine particle inhaled corticosteroids to standard therapy in severe asthma. Methods: Severe asthmatics taking =1600µg/day budesonide or equivalent performed a randomised open-label crossover study. Subjects with FEV(1)

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