Interval cancers in a FOBT-based colorectal cancer population screening programme : implications for stage, gender and tumour site. / Steele, R. J. C.; McClements, P.; Watling, C.; Libby, G.; Weller, D.; Brewster, D .H.; Black, R.; Carey, F. A.; Fraser, C. G.
In: Gut, Vol. 61, No. 4, 01.04.2012, p. 576-581.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Interval cancers in a FOBT-based colorectal cancer population screening programme
T2 - implications for stage, gender and tumour site
A1 - Steele,R. J. C.
A1 - McClements,P.
A1 - Watling,C.
A1 - Libby,G.
A1 - Weller,D.
A1 - Brewster,D .H.
A1 - Black,R.
A1 - Carey,F. A.
A1 - Fraser,C. G.
AU - Steele,R. J. C.
AU - McClements,P.
AU - Watling,C.
AU - Libby,G.
AU - Weller,D.
AU - Brewster,D .H.
AU - Black,R.
AU - Carey,F. A.
AU - Fraser,C. G.
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Background: Between 2000 and 2007, a demonstration pilot of biennial guaiac faecal occult blood test (GFOBT) screening was carried out in Scotland. Methods: Interval cancers were defined as cancers diagnosed within 2 years (ie, a complete screening round) of a negative GFOBT. The stage and outcome of the interval cancers were compared with those arising contemporaneously in the non-screened Scottish population. In addition, the gender and site distributions of the interval cancers were compared with those in the screen-detected group and the non-screened population. Results: Of the cancers diagnosed in the screened population, interval cancers comprised 31.2% in the first round, 47.7% in the second, and 58.9% in the third, although this was due to a decline in the numbers of screen-detected cancers rather than an increase in interval cancers. There were no consistent differences in the stage distribution of interval cancers and cancers from the non-screened population, and, in all three rounds, both overall and cancer-specific survival were significantly better for patients diagnosed with interval cancers (p
AB - Background: Between 2000 and 2007, a demonstration pilot of biennial guaiac faecal occult blood test (GFOBT) screening was carried out in Scotland. Methods: Interval cancers were defined as cancers diagnosed within 2 years (ie, a complete screening round) of a negative GFOBT. The stage and outcome of the interval cancers were compared with those arising contemporaneously in the non-screened Scottish population. In addition, the gender and site distributions of the interval cancers were compared with those in the screen-detected group and the non-screened population. Results: Of the cancers diagnosed in the screened population, interval cancers comprised 31.2% in the first round, 47.7% in the second, and 58.9% in the third, although this was due to a decline in the numbers of screen-detected cancers rather than an increase in interval cancers. There were no consistent differences in the stage distribution of interval cancers and cancers from the non-screened population, and, in all three rounds, both overall and cancer-specific survival were significantly better for patients diagnosed with interval cancers (p
KW - Adult
KW - Aged
KW - Article
KW - Cancer localization
KW - Cancer prognosis
KW - Cancer screening
KW - Cancer specific survival
KW - Cancer staging
KW - Clinical evaluation
KW - Colorectal cancer
KW - Controlled study
KW - Diagnostic accuracy
KW - Disease duration
KW - Female
KW - Human
KW - Major clinical study
KW - Male
KW - Occult blood test
KW - Overall survival
KW - Pathological anatomy
KW - Priority journal
KW - Sex difference
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84857798015&md5=51126474df03e827f6ebb04dd4945468
U2 - 10.1136/gutjnl-2011-300535
DO - 10.1136/gutjnl-2011-300535
M1 - Article
JO - Gut
JF - Gut
SN - 0017-5749
IS - 4
VL - 61
SP - 576
EP - 581
ER -