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Interventions for treating oral mucositis for patients with cancer receiving treatment

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Interventions for treating oral mucositis for patients with cancer receiving treatment. / Clarkson, Jan E.; Worthington, Helen V.; Furness, Susan; McCabe, Martin; Khalid, Tasneem; Meyer, Stefan.

In: Cochrane Database of Systematic Reviews, No. 10, CD001973, 2010, p. -.

Research output: Contribution to journalScientific review

Harvard

Clarkson, JE, Worthington, HV, Furness, S, McCabe, M, Khalid, T & Meyer, S 2010, 'Interventions for treating oral mucositis for patients with cancer receiving treatment' Cochrane Database of Systematic Reviews, no. 10, CD001973, pp. -.

APA

Clarkson, J. E., Worthington, H. V., Furness, S., McCabe, M., Khalid, T., & Meyer, S. (2010). Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database of Systematic Reviews, (10), -[CD001973]doi: 10.1002/14651858.CD001973.pub4

Vancouver

Clarkson JE, Worthington HV, Furness S, McCabe M, Khalid T, Meyer S. Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database of Systematic Reviews. 2010;(10):-. CD001973.

Author

Clarkson, Jan E.; Worthington, Helen V.; Furness, Susan; McCabe, Martin; Khalid, Tasneem; Meyer, Stefan / Interventions for treating oral mucositis for patients with cancer receiving treatment.

In: Cochrane Database of Systematic Reviews, No. 10, CD001973, 2010, p. -.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{ec6d103826714081b75a24834febdf1a,
title = "Interventions for treating oral mucositis for patients with cancer receiving treatment",
author = "Clarkson, {Jan E.} and Worthington, {Helen V.} and Susan Furness and Martin McCabe and Tasneem Khalid and Stefan Meyer",
year = "2010",
number = "10",
pages = "--",
journal = "Cochrane Database of Systematic Reviews",
issn = "1469-493X",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Interventions for treating oral mucositis for patients with cancer receiving treatment

A1 - Clarkson,Jan E.

A1 - Worthington,Helen V.

A1 - Furness,Susan

A1 - McCabe,Martin

A1 - Khalid,Tasneem

A1 - Meyer,Stefan

AU - Clarkson,Jan E.

AU - Worthington,Helen V.

AU - Furness,Susan

AU - McCabe,Martin

AU - Khalid,Tasneem

AU - Meyer,Stefan

PY - 2010

Y1 - 2010

N2 - <p>Background</p> <p>Treatment of cancer is increasingly effective but associated with short and long term side effects. Oral side effects, including oral mucositis (mouth ulceration), remain a major source of illness despite the use of a variety of agents to treat them.</p> <p>Objectives</p> <p>To assess the effectiveness of interventions for treating oral mucositis or its associated pain in patients with cancer receiving chemotherapy or radiotherapy or both.</p> <p>Search strategy</p> <p>Electronic searches of Cochrane Oral Health Group and PaPaS Trials Registers (to 1 June 2010), CENTRAL via The Cochrane Library (to Issue 2, 2010), MEDLINE via OVID (1950 to 1 June 2010), EMBASE via OVID (1980 to 1 June 2010), CINAHL via EBSCO (1980 to 1 June 2010), CANCERLIT via PubMed (1950 to 1 June 2010), OpenSIGLE (1980 to 1 June 2010) and LILACS via the Virtual Health Library (1980 to 1 June 2010) were undertaken. Reference lists from relevant articles were searched and the authors of eligible trials were contacted to identify trials and obtain additional information.</p> <p>Selection criteria</p> <p>All randomised controlled trials comparing agents prescribed to treat oral mucositis in people receiving chemotherapy or radiotherapy or both. Outcomes were oral mucositis, time to heal mucositis, oral pain, duration of pain control, dysphagia, systemic infection, amount of analgesia, length of hospitalisation, cost and quality of life.</p> <p>Data collection and analysis</p> <p>Data were independently extracted, in duplicate, by two review authors. Authors were contacted for details of randomisation, blindness and withdrawals. Risk of bias assessment was carried out on six domains. The Cochrane Collaboration statistical guidelines were followed and risk ratio (RR) values calculated using fixed-effect models (less than 3 trials in each meta-analysis).</p> <p>Main results</p> <p>Thirty-two trials involving 1505 patients satisfied the inclusion criteria. Three comparisons for mucositis treatment including two or more trials were: benzydamine HCl versus placebo, sucralfate versus placebo and low level laser versus sham procedure. Only the low level laser showed a reduction in severe mucositis when compared with the sham procedure, RR 5.28 (95% confidence interval (CI) 2.30 to 12.13).</p> <p>Only 3 comparisons included more than one trial for pain control: patient controlled analgesia (PCA) compared to the continuous infusion method, therapist versus control, cognitive behaviour therapy versus control. There was no evidence of a difference in mean pain score between PCA and continuous infusion, however, less opiate was used per hour for PCA, mean difference 0.65 mg/hour (95% CI 0.09 to 1.20), and the duration of pain was less 1.9 days (95% CI 0.3 to 3.5).</p> <p>Authors' conclusions</p> <p>There is weak and unreliable evidence that low level laser treatment reduces the severity of the mucositis. Less opiate is used for PCA versus continuous infusion. Further, well designed, placebo or no treatment controlled trials assessing the effectiveness of interventions investigated in this review and new interventions for treating mucositis are needed.<br/> <strong>This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2010, Issue 10. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.</strong></p>

AB - <p>Background</p> <p>Treatment of cancer is increasingly effective but associated with short and long term side effects. Oral side effects, including oral mucositis (mouth ulceration), remain a major source of illness despite the use of a variety of agents to treat them.</p> <p>Objectives</p> <p>To assess the effectiveness of interventions for treating oral mucositis or its associated pain in patients with cancer receiving chemotherapy or radiotherapy or both.</p> <p>Search strategy</p> <p>Electronic searches of Cochrane Oral Health Group and PaPaS Trials Registers (to 1 June 2010), CENTRAL via The Cochrane Library (to Issue 2, 2010), MEDLINE via OVID (1950 to 1 June 2010), EMBASE via OVID (1980 to 1 June 2010), CINAHL via EBSCO (1980 to 1 June 2010), CANCERLIT via PubMed (1950 to 1 June 2010), OpenSIGLE (1980 to 1 June 2010) and LILACS via the Virtual Health Library (1980 to 1 June 2010) were undertaken. Reference lists from relevant articles were searched and the authors of eligible trials were contacted to identify trials and obtain additional information.</p> <p>Selection criteria</p> <p>All randomised controlled trials comparing agents prescribed to treat oral mucositis in people receiving chemotherapy or radiotherapy or both. Outcomes were oral mucositis, time to heal mucositis, oral pain, duration of pain control, dysphagia, systemic infection, amount of analgesia, length of hospitalisation, cost and quality of life.</p> <p>Data collection and analysis</p> <p>Data were independently extracted, in duplicate, by two review authors. Authors were contacted for details of randomisation, blindness and withdrawals. Risk of bias assessment was carried out on six domains. The Cochrane Collaboration statistical guidelines were followed and risk ratio (RR) values calculated using fixed-effect models (less than 3 trials in each meta-analysis).</p> <p>Main results</p> <p>Thirty-two trials involving 1505 patients satisfied the inclusion criteria. Three comparisons for mucositis treatment including two or more trials were: benzydamine HCl versus placebo, sucralfate versus placebo and low level laser versus sham procedure. Only the low level laser showed a reduction in severe mucositis when compared with the sham procedure, RR 5.28 (95% confidence interval (CI) 2.30 to 12.13).</p> <p>Only 3 comparisons included more than one trial for pain control: patient controlled analgesia (PCA) compared to the continuous infusion method, therapist versus control, cognitive behaviour therapy versus control. There was no evidence of a difference in mean pain score between PCA and continuous infusion, however, less opiate was used per hour for PCA, mean difference 0.65 mg/hour (95% CI 0.09 to 1.20), and the duration of pain was less 1.9 days (95% CI 0.3 to 3.5).</p> <p>Authors' conclusions</p> <p>There is weak and unreliable evidence that low level laser treatment reduces the severity of the mucositis. Less opiate is used for PCA versus continuous infusion. Further, well designed, placebo or no treatment controlled trials assessing the effectiveness of interventions investigated in this review and new interventions for treating mucositis are needed.<br/> <strong>This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2010, Issue 10. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.</strong></p>

KW - Mouth Diseases [etiology; therapy]

KW - Mouth Mucosa

KW - Neoplasms [therapy]

KW - Pain [etiology; therapy]

KW - Randomized Controlled Trials as Topic

KW - Stomatitis [complications;therapy]

KW - Humans

KW - BONE-MARROW-TRANSPLANTATION

KW - COLONY-STIMULATING FACTOR

KW - RADIOTHERAPY-INDUCED MUCOSITIS

KW - STEM-CELL TRANSPLANTATION

KW - CHEMOTHERAPY-INDUCED STOMATITIS

KW - PROSPECTIVE RANDOMIZED-TRIAL

KW - RADIATION-INDUCED MUCOSITIS

KW - CONTROLLED CLINICAL-TRIAL

KW - DOUBLE-BLIND

KW - NECK-CANCER

U2 - 10.1002/14651858.CD001973.pub4

DO - 10.1002/14651858.CD001973.pub4

M1 - Scientific review

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

SN - 1469-493X

IS - 10

SP - -

ER -

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